MOTOR FUNCTION AND COGNITIVE DECLINE IN AGING PRIMATES

衰老灵长类动物的运动功能和认知能力下降

• 批准号: 7716008
• 负责人: HENRYK F URBANSKI
• 金额: $ 5.55万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716008
• 关键词: Age; Age-associated memory impairment; Aging; Animal Model; Circadian Rhythms; Clinical; Cognitive aging; Complex; Computer Retrieval of Information on Scientific Projects Database; Condition; Data; Delayed Memory; Development Plans; Diet; Disruption; Food; Funding; Future; Gonadal Steroid Hormones; Grant; Home environment; Human; Impaired cognition; Institution; Link; Locomotion; Macaca mulatta; Measurement; Monitor; Motor; Pharmaceutical Preparations; Photoperiod; Pilot Projects; Primates; Reaction Time; Research; Research Personnel; Resources; Retrieval; Sampling; Series; Short-Term Memory; Sleep; Source; Speed; Temperature; Testing; United States National Institutes of Health; cognitive function; cost; human study; indexing; memory recognition; research study; response; therapy development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently, the mechanisms linking motor decline and cognitive loss are poorly understood. To help overcome this problem, we are conducting a series of experiments using the rhesus monkey (Macaca mulatta), which like humans shows cognitive decline during aging. Moreover, it can be maintained under carefully controlled environmental conditions (e.g., diet, temperature, photoperiod, medication, and sex-steroid exposure). In this ongoing pilot study, we are assessing cognitive function using the delayed response test of spatial working memory, the delayed non-matching-to-sample test of recognition memory, and complex reaction time; we are also assessing motor speed with a simple reaction time task, fine motor function with food retrieval tasks, locomotor function with videotracking analysis of spontaneous and motivated locomotion, and circadian activity and sleep quality indices with continuous home cage monitoring. These measurements enable us to test the hypotheses that age-associated motor decline and circadian rhythm disruption are closely correlated with concurrent age-associated cognitive decline. This pilot study represents a rapid and cost-effective way of establishing whether the rhesus monkey can act as a pragmatic animal model for future mechanistic studies and for the development of treatment strategies. Moreover, the data will be valuable to our clinical collaborators at OHSU, who are planning the development and implementation of related human studies, and to other investigators who are studying human cognitive aging.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目前，运动能力下降和认知能力丧失之间的联系机制尚不清楚。为了帮助克服这个问题，我们正在用恒河猴（Macaca mulatta）进行一系列实验，恒河猴和人类一样，在衰老过程中表现出认知能力下降。此外，它可以在仔细控制的环境条件下保持（例如，饮食、温度、光周期、药物和性类固醇暴露）。在这项正在进行的试点研究中，我们正在评估认知功能，使用空间工作记忆的延迟反应测试，识别记忆的延迟非匹配样本测试和复杂反应时间;我们还通过简单的反应时间任务来评估运动速度，通过食物获取任务来评估精细运动功能，通过自发和主动运动的视频跟踪分析来评估运动功能，和昼夜活动和睡眠质量指数与连续的家庭笼监测。 这些测量使我们能够测试的假设，年龄相关的运动衰退和昼夜节律的破坏是密切相关的并发年龄相关的认知能力下降。这项试点研究代表了一种快速且具有成本效益的方法，可以确定恒河猴是否可以作为未来机制研究和治疗策略开发的实用动物模型。此外，这些数据对于OHSU的临床合作者以及其他正在研究人类认知老化的研究人员来说都是有价值的，他们正在计划相关人类研究的开发和实施。