MOTOR FUNCTION AND COGNITIVE DECLINE IN AGING PRIMATES

衰老灵长类动物的运动功能和认知能力下降

• 批准号: 7958509
• 负责人: HENRYK F URBANSKI
• 金额: $ 8.03万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-04 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958509
• 关键词: Age; Age-associated memory impairment; Aging; Animal Model; Circadian Rhythms; Clinical; Cognitive aging; Complex; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Development Plans; Diet; Food; Funding; Future; Gonadal Steroid Hormones; Grant; Home environment; Human; Impaired cognition; Institution; Link; Locomotion; Macaca mulatta; Measurement; Monitor; Motor; Pharmaceutical Preparations; Photoperiod; Pilot Projects; Primates; Reaction Time; Research; Research Personnel; Resources; Retrieval; Sampling; Series; Short-Term Memory; Sleep; Source; Speed; Temperature; Testing; United States National Institutes of Health; cognitive function; cost; indexing; locomotor tasks; memory recognition; research study; response; treatment strategy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently, the mechanisms linking motor decline and cognitive loss are poorly understood. To help overcome this problem, we are conducting a series of experiments using the rhesus monkey (Macaca mulatta), which like humans shows cognitive decline during aging. Moreover, it can be maintained under carefully controlled environmental conditions (e.g., diet, temperature, photoperiod, medication, and sex-steroid exposure). In this ongoing pilot study, we are assessing cognitive function using the delayed response test of spatial working memory, the delayed non-matching-to-sample test of recognition memory, and complex reaction time; we are also assessing motor speed with a simple reaction time task, fine motor function with food retrieval tasks, locomotor function with videotracking analysis of spontaneous and motivated locomotion, and circadian activity and sleep quality indices with continuous home cage monitoring. These measurements enable us to test the hypotheses that age-associated motor decline and circadian rhythm disruption are closely correlated with concurrent age-associated cognitive decline. This pilot study represents a rapid and cost-effective way of establishing whether the rhesus monkey can act as a pragmatic animal model for future mechanistic studies and for the development of treatment strategies. Moreover, the data will be valuable to our clinical collaborators at OHSU, who are planning the development and implementation of related human studies, and to other investigators who are studying human cognitive aging.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目前，人们对运动能力下降和认知丧失之间的联系机制知之甚少。为了帮助克服这个问题，我们正在利用恒河猴（Macaca mulatta）进行一系列实验，恒河猴与人类一样，在衰老过程中表现出认知能力下降。此外，它可以在仔细控制的环境条件（例如饮食、温度、光周期、药物和性类固醇暴露）下维持。在这项正在进行的试点研究中，我们正在使用空间工作记忆的延迟反应测试、识别记忆的延迟非匹配样本测试和复杂反应时间来评估认知功能；我们还通过简单的反应时间任务来评估运动速度，通过食物检索任务来评估精细运动功能，通过对自发和主动运动的视频跟踪分析来评估运动功能，以及通过连续的家笼监测来评估昼夜节律活动和睡眠质量指数。这些测量使我们能够检验以下假设：与年龄相关的运动能力下降和昼夜节律紊乱与同时发生的与年龄相关的认知能力下降密切相关。这项试点研究代表了一种快速且经济有效的方法，可以确定恒河猴是否可以作为未来机制研究和治疗策略开发的实用动物模型。此外，这些数据对于我们在 OHSU 的临床合作者以及正在研究人类认知衰老的其他研究人员来说都很有价值，他们正在计划开发和实施相关的人类研究。