Harvard Systems Biology Graduate Program

项目概要/摘要 本申请请求支持哈佛大学系统生物学博士项目。这 深刻的跨学科课程吸引了顶尖的学生，从纯数学到 医学，并为他们提供资源和支持，以制定一个独立的和定量的方法， 重要的生物学问题。系统生物学计划将系统生物学研究整合到整个 整个哈佛大学，包括哈佛的主校区（剑桥）和基础科学系 哈佛医学院（HMS）及其教学医院，创建一个真正统一的跨哈佛 该计划鼓励学生的创造力和研究领域和未来职业的选择。 生物系统的行为是复杂的，往往是不可预测的，在某种程度上，深刻地挑战了我们的 诊断和治疗疾病或了解我们周围世界的行为的能力。我们认为 学生谁都有定量测量技术和数学或 计算方法将开发出创造性的新方法来解决生物系统的复杂性。 该计划也是一个主要的工具，使定量和理论的方法到相关问题 去诊所 自上次提交该补助金以来，该计划已朝着有代表性的学生迈出了重大步伐。 人口：今年，女性科学家首次在8名女性的进入队列中占多数 与往年相比，2017-18年度来自代表性不足的少数民族的申请人数翻了一番。 获得学位的平均时间为5.4年。上一笔赠款资助了6名受训人员。在这段时间里，我们 为8名学员提供支持。 哈佛系统生物学博士课程是一个开创性的计划和正在进行的实验。程序 旨在帮助学生识别生物学问题，跨学科的方法可以提供独特的 令人满意的答案，并准备他们在未来的职业生涯中识别和解决这些问题。的 程序特别注意严谨性和再现性，培养学生的物理化学基础， 他们所做的测量和适当的技术，以及统计分析中的常见陷阱。 跨学科和与非专业公众沟通的培训是该计划的基础， 贯穿于每个学生的职业生涯。

Project Summary/abstract This application requests support for the PhD Program in Systems Biology at Harvard University. This profoundly interdisciplinary program attracts top students with backgrounds ranging from pure mathematics to medicine, and offers them the resources and support to develop an independent and quantitative approach to important biological questions. The Systems Biology program integrates systems biology research across the whole of Harvard University, including Harvard's main (Cambridge) campus and the basic science departments of Harvard Medical School (HMS) and its teaching hospitals, creating a genuinely unified cross-Harvard program that encourages student creativity and choice of both research area and of future career. The behavior of biological systems is complex and often unpredictable, in ways that profoundly challenge our ability to diagnose and treat diseases or understand the behavior of the world around us. We believe that students who have a deep understanding of both quantitative measurement technologies and mathematical or computational approaches will develop creative new ways to grapple with the complexity of biological systems. The program is also a major vehicle for bringing quantitative and theoretical approaches into problems relevant to the clinic. Since the last submission of this grant, the program has made major strides towards a representative student population: this year, for the first time, female scientists are in the majority in the entering cohort of 8 women and 3 men and applications from underrepresented minorities doubled in 2017-18 compared to previous years. The average time to degree is 5.4 years. The previous grant supported 6 trainees. In this funding period we request support for 8 trainees. The Harvard Systems Biology PhD Program is a pioneering program and an ongoing experiment. The program aims to help students identify biological questions to which an interdisciplinary approach can provide uniquely satisfying answers, and to prepare them to identify and address such questions in their future careers. The program pays particular attention to rigor and reproducibility, training students in the physicochemical basis of the measurements they make and in appropriate techniques, and common pitfalls, in statistical analysis. Training for communication across disciplines and to the lay public is foundational for the Program and is emphasized throughout each student's career.