Stroke and Alzheimers Disease Related Dementias

中风和阿尔茨海默病相关的痴呆症

• 批准号: 10410736
• 负责人: JAMES W. SIMPKINS
• 金额: $ 42.02万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410736
• 关键词: Alzheimer' s disease related dementia; Stroke

Project Summary Stroke - like many brain diseases - is clearly associated with aging and a plethora of age-related co-morbid conditions, including cognitive decline, Alzheimer’s disease (AD), AD related dementias, multi-infarct dementia, cardiovascular disease, cerebrovascular disease, hypertension, hypercholesterolemia, immune suppression, metabolic syndrome and obesity, sleep deprivation, and depression. However, age-related co-morbid conditions, as a variable in stroke occurrence, severity and long-term recovery is seldom studied experimentally, but is one of the identified factors in the lack of progress in the discovery of new therapies for acute stroke brain damage. To optimize the impact of our research on the discovery of new preventatives, acute treatments and rehabilitation methods for stroke, we need to train the next generation of stroke researchers to assess stroke in the context of the affected patent population: those who are elderly and have multiple co-morbid conditions. The Stroke and Alzheimer’s Disease Related Dementias Predoctoral Training Program will formalize and standardize our already strong training programs in the biomedical sciences and focus on stroke research. A number of innovative aspects of this training program are semester-long didactic courses in “Stroke” and the “Neurobiology of Aging”, a clinical immersion in our WVU Stroke Center, a in Stroke Journal Club, an Associate Scholars Program, and experience in community engagement. The proposed training program will select the best PhD students from the participating Biomedical Sciences Training programs at the West Virginia University (WVU) Health Science Center (WVU HSC) and will prepare them with the skills, knowledge and acumen needed for a successful career in stroke research. The specific training for each of 8 mentee will be tailored based on their annually updated Individualized Development Plan (IDP), and an “Exploring Career Paths” Program will help prepare them for their chosen career. Program training is expected to last 2-to-3 years. This pre-doctoral training program will create a new generation of young scholars who can address the need for innovative stroke research for the citizens of West Virginia and the nation.

项目摘要 中风-像许多脑部疾病一样-显然与衰老和大量与年龄相关的共病有关。 病症，包括认知衰退、阿尔茨海默病（AD）、AD相关痴呆、多梗塞性痴呆， 心血管疾病、脑血管疾病、高血压、高胆固醇血症、免疫抑制， 代谢综合征和肥胖症，睡眠剥夺和抑郁症。然而，与年龄相关的共病， 作为中风发生、严重程度和长期恢复的一个变量，很少有实验研究， 在发现急性中风脑损伤的新疗法方面缺乏进展的已确定因素。 优化我们的研究对发现新的预防、急性治疗和康复方法的影响 我们需要培训下一代中风研究人员，以评估中风的背景下， 受影响的患者人群：老年人和患有多种共病的患者。笔划和 阿尔茨海默病相关痴呆博士前培训计划将正式化和标准化我们已经 强大的生物医学科学培训计划，并专注于中风研究。一批创新 该培训计划的各个方面是“中风”和“衰老神经生物学”的学期教学课程， 在我们的西弗吉尼亚大学中风中心的临床沉浸，中风杂志俱乐部，副学者计划，和 社区参与的经验。拟议的培训计划将选择最好的博士生从 参与西弗吉尼亚大学（WVU）健康科学的生物医学科学培训计划 中心（西弗吉尼亚大学HSC），并将准备他们的技能，知识和敏锐性需要一个成功的职业生涯 在中风研究中。8名学员的具体培训将根据他们每年更新的 个性化发展计划（IDP）和“探索职业道路”计划将帮助他们为未来的职业生涯做好准备。 选择职业项目培训预计将持续2至3年。这个博士前培训计划将创建一个 新一代的年轻学者谁可以解决创新中风研究的公民的需要， 西弗吉尼亚州和全国。