Stroke and Alzheimers Disease Related Dementias

项目摘要 中风--就像许多脑部疾病一样--显然与衰老和过多的与年龄相关的共病有关 疾病，包括认知功能减退、阿尔茨海默病(AD)、AD相关痴呆、多发性梗死性痴呆、 心血管疾病、脑血管疾病、高血压、高胆固醇血症、免疫抑制 代谢综合征和肥胖、睡眠不足和抑郁。然而，与年龄相关的合并症， 作为中风发生的一个变量，严重程度和长期恢复很少进行实验研究，但这是一个 在发现急性中风脑损伤的新疗法方面缺乏进展的已确定因素中。 优化我们的研究对发现新的预防、急性治疗和康复的影响 对于中风的方法，我们需要培养下一代中风研究人员，在评估中风的背景下 受影响的专利人群：那些年事已高且有多种并存疾病的人。中风和 阿尔茨海默病相关痴呆症博士前培训计划将使我们已经 在生物医学科学方面有很强的培训计划，并专注于中风研究。一些创新的 这个培训项目包括为期一学期的“中风”和“衰老的神经生物学”的教学课程， 我们西弗吉尼亚大学卒中中心的临床沉浸，卒中杂志俱乐部，副学者项目，以及 社区参与方面的经验。拟议的培训计划将从以下项目中挑选最好的博士生 参与西弗吉尼亚大学(WVU)健康科学的生物医学科学培训项目 中心(西弗吉尼亚大学HSC)，并将为他们培养成功的职业生涯所需的技能、知识和敏锐性 在中风研究中。8名学员的具体培训将根据他们每年更新的情况量身定做 个人化发展计划(IDP)和“探索职业道路”计划将帮助他们做好准备 选择的职业。计划培训预计将持续2至3年。这一博士前培训计划将创造一个 新一代的年轻学者，他们可以满足公民对创新中风研究的需求 西弗吉尼亚州和整个国家。

Project Summary Stroke - like many brain diseases - is clearly associated with aging and a plethora of age-related co-morbid conditions, including cognitive decline, Alzheimer’s disease (AD), AD related dementias, multi-infarct dementia, cardiovascular disease, cerebrovascular disease, hypertension, hypercholesterolemia, immune suppression, metabolic syndrome and obesity, sleep deprivation, and depression. However, age-related co-morbid conditions, as a variable in stroke occurrence, severity and long-term recovery is seldom studied experimentally, but is one of the identified factors in the lack of progress in the discovery of new therapies for acute stroke brain damage. To optimize the impact of our research on the discovery of new preventatives, acute treatments and rehabilitation methods for stroke, we need to train the next generation of stroke researchers to assess stroke in the context of the affected patent population: those who are elderly and have multiple co-morbid conditions. The Stroke and Alzheimer’s Disease Related Dementias Predoctoral Training Program will formalize and standardize our already strong training programs in the biomedical sciences and focus on stroke research. A number of innovative aspects of this training program are semester-long didactic courses in “Stroke” and the “Neurobiology of Aging”, a clinical immersion in our WVU Stroke Center, a in Stroke Journal Club, an Associate Scholars Program, and experience in community engagement. The proposed training program will select the best PhD students from the participating Biomedical Sciences Training programs at the West Virginia University (WVU) Health Science Center (WVU HSC) and will prepare them with the skills, knowledge and acumen needed for a successful career in stroke research. The specific training for each of 8 mentee will be tailored based on their annually updated Individualized Development Plan (IDP), and an “Exploring Career Paths” Program will help prepare them for their chosen career. Program training is expected to last 2-to-3 years. This pre-doctoral training program will create a new generation of young scholars who can address the need for innovative stroke research for the citizens of West Virginia and the nation.