Predoctoral Training in Stroke and its Co-Morbidities

中风及其并发症的博士前培训

• 批准号: 10212200
• 负责人: JAMES W. SIMPKINS
• 金额: $ 29.47万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10212200
• 关键词: Stroke; Training; comorbidity; pre-doctoral

Project Summary Stroke - like many brain diseases - is clearly associated with aging and a plethora of age-related co-morbid conditions, including cognitive decline, Alzheimer’s disease (AD), multi-infarct dementia, cardiovascular disease, cerebrovascular disease, hypertension, hypercholesterolemia, immune suppression, metabolic syndrome and obesity, sleep deprivation, and depression. However, age-related co-morbid conditions, as a variable in stroke occurrence, severity and long- term recovery is seldom studied experimentally, but is one of the identified factors in the lack of progress in the discovery of new therapies for acute stroke brain damage. To optimize the impact of our research on the discovery of new preventatives, acute treatments and rehabilitation methods for stroke, we need to train the next generation of stroke researchers to assess stroke in the context of the affected patent population: those who are elderly and have multiple co-morbid conditions. The Stroke and Its Co-morbidities Predoctoral Training Program will formalize and standardize our already strong training programs in the biomedical sciences and focus on stroke research. A number of innovative aspects of this training program are semester-long didactic courses in “Stroke” and the “Neurobiology of Aging”, a clinical immersion in our WVU Stroke Center, a Neuroscience Emerging Research Discoveries in Stroke (NERDS) journal club, an Associate Scholars Program, and experience in community engagement. The proposed training program will select the best PhD students from the participating Biomedical Sciences Training programs at the West Virginia University (WVU) Health Science Center (WVU HSC) and will prepare them with the skills, knowledge and acumen needed for a successful career in stroke research. The specific training for each of 6 mentee will be tailored based on their annually updated Individualized Development Plan (IDP), and an “Exploring Career Paths” Program will help prepare them for their chosen career. Program training is expected to last 2-to-3 years. This pre-doctoral training program will create a new generation of young scholars who can address the need for innovative stroke research for the citizens of West Virginia and the nation.

项目摘要 中风-像许多脑部疾病一样-显然与衰老和大量与年龄有关的疾病有关。 共病状况，包括认知下降、阿尔茨海默病（AD）、多发性梗死 痴呆、心血管疾病、脑血管疾病、高血压、高胆固醇血症， 免疫抑制、代谢综合征和肥胖症、睡眠剥夺和抑郁症。 然而，年龄相关的共病状况，作为中风发生率、严重程度和长期 术语恢复很少被实验研究，但它是缺乏 在发现急性中风脑损伤的新疗法方面取得进展。为了优化影响 我们在发现新的预防措施、急性治疗和康复方面的研究 我们需要培训下一代中风研究人员来评估中风 在受影响的患者人群中：老年人和患有多种共病的患者 条件中风及其合并症博士前培训计划将正式化， 规范我们在生物医学科学方面已经很强的培训计划， research.这个培训计划的许多创新方面是学期教学 课程“中风”和“衰老的神经生物学”，在我们的WVU中风临床沉浸 中心，一个神经科学新兴研究发现中风（NERDS）杂志俱乐部， 副学者计划，并在社区参与的经验。拟议的培训 该计划将选择最好的博士生从参与生物医学科学培训 西弗吉尼亚大学（WVU）健康科学中心（WVU HSC）的课程，并将 为他们提供成功的中风职业生涯所需的技能，知识和敏锐度 research. 6名学员的具体培训将根据他们的年度 更新的个性化发展计划（IDP）和“探索职业道路”计划将 帮助他们为自己选择的职业做好准备。项目培训预计将持续2至3年。这 博士前培训计划将创造新一代的年轻学者谁可以解决 西弗吉尼亚州公民和国家对创新中风研究的需求。