West Virginia Stroke CoBRE

描述（由申请人提供）：提议的是西弗吉尼亚州中风CoBRE（以下简称中风CoBRE），重点是中风领域。中风CoBRE是作为基础和转化中风研究中心（CBTSR）的重要组成部分发起的，CBTSR是一个新成立的中心，专注于加强西弗吉尼亚大学（WVU）校园的基础和转化中风研究，以减轻中风的负担。我们的方法是解决风险因素的机制，特别是在我们的阿巴拉契亚人口中普遍存在的风险因素，影响中风，从而破译这些风险因素的机制和针对这些机制的潜在治疗。我们设想CBTSR将成为一个国家卓越的基础和转化脑卒中研究中心，解决从病床到社区脑卒中问题。这将通过培养初级研究人员的研究独立性和开发支持西弗吉尼亚大学中风研究社区的核心资源来实现，从而增加西弗吉尼亚大学致力于中风研究的资源和人员，以实现程序化的研究活动。提出了3个核心和5个研究项目。行政核心将管理中风CoBRE的各个方面，包括密集的初级教师指导计划、咨询委员会和项目评估。脑卒中实验中心将为初级研究者以及西弗吉尼亚大学神经科学和心血管研究界提供资源、专业知识和脑卒中实验程序。生物统计学核心将在初级研究者发起的项目的设计和实施过程中提供关键的生物统计学支持。建议的研究项目从5名致力于通过CoBRE机制开发独立研究项目的初级研究员中选出。总的来说，他们的研究项目涉及中风预测、病因、预防、急性治疗和康复等相关领域。整个项目有一个完善的和密集的指导计划和一个严格的总结和形成性评估计划。还建议以聘用教员、建造设施和提供监测捐款的形式提供体制支助。

DESCRIPTION (provided by applicant): Proposed is the West Virginia Stroke CoBRE (here after called the Stroke CoBRE) with a focus area of stroke. The Stroke CoBRE was initiated as an essential part of the Center for Basic and Translational Stroke Research (CBTSR), a newly formed Center that is focused on enhancing basic and translational stroke research on the West Virginia University (WVU) campus to reduce the burden of stroke. Our approach is to address the mechanisms by which risk factors, particularly prevalent in our Appalachian population, affect stroke and thereby to decipher mechanisms of these risk factors and potential treatments that target these mechanisms. We envision that the CBTSR will become a national center of excellence in basic and translational stroke research that addresses bench to bed-side to community Issues in stroke. This will be accomplished through the development of junior Investigators to research Independence, and the development of core resources that support the WVU stroke research community, thereby enhancing resources and personnel devoted to stroke research at the WVU to achieve programmatic research activities. Three cores and five research projects are proposed. The Administrative Core will manage the various aspects of the Stroke CoBRE, including an intense junior faculty mentoring program, advisory committees and program evaluation. The Experimental Stroke Core will provide resources, expertise and experimental stroke procedures to junior Investigators as well as to the WVU neuroscience and cardiovascular research community. The Biostatistics Core will provide critical biostatistical support during the design and conduct of the junior Investigator-Initiated projects. The research projects proposed eminate from 5 junior Investigators who are committed to developing independent research programs through the CoBRE mechanism. Collectively, their research projects address the linked areas of stroke prediction, causes, prevention, acute treatment and rehabilitation. The program-as-a-whole has a well-developed and Intensive mentoring program and a rigorous summative and formative evaluation program. Institutional support is also proposed, in the form of faculty hires, facilities construction and monitary contributions.