West Virginia Stroke CoBRE

描述（由申请人提供）：拟定的是西弗吉尼亚州卒中CoBRE（以下称为卒中CoBRE），重点关注卒中领域。Stroke CoBRE是基础和转化卒中研究中心（CBTSR）的重要组成部分，CBTSR是一个新成立的中心，专注于加强西弗吉尼亚大学（WVU）校园的基础和转化卒中研究，以减轻卒中的负担。我们的方法是解决风险因素，特别是在我们的阿巴拉契亚人群中普遍存在的风险因素影响中风的机制，从而破译这些风险因素的机制和针对这些机制的潜在治疗方法。我们设想CBTSR将成为基础和转化卒中研究的国家卓越中心，解决卒中中的板凳到床边到社区问题。这将通过发展初级研究者来实现研究独立性，并开发支持WVU卒中研究社区的核心资源，从而增加WVU卒中研究的资源和人员，以实现计划性研究活动。提出了三个核心和五个研究项目。行政核心将管理中风CobRE的各个方面，包括一个激烈的初级教师辅导计划，咨询委员会和计划评估。实验中风核心将提供资源，专业知识和实验中风程序，初级研究人员以及西弗吉尼亚大学神经科学和心血管研究社区。生物统计学核心将在初级研究者发起的项目的设计和实施期间提供关键的生物统计学支持。提出的研究项目来自5名初级研究员，他们致力于通过CoBRE机制开发独立的研究项目。总的来说，他们的研究项目涉及中风预测，病因，预防，急性治疗和康复的相关领域。该计划作为一个整体有一个完善的和密集的辅导计划和严格的总结性和形成性评估计划。还提出了机构支持，以教师招聘，设施建设和监测捐款的形式。

DESCRIPTION (provided by applicant): Proposed is the West Virginia Stroke CoBRE (here after called the Stroke CoBRE) with a focus area of stroke. The Stroke CoBRE was initiated as an essential part of the Center for Basic and Translational Stroke Research (CBTSR), a newly formed Center that is focused on enhancing basic and translational stroke research on the West Virginia University (WVU) campus to reduce the burden of stroke. Our approach is to address the mechanisms by which risk factors, particularly prevalent in our Appalachian population, affect stroke and thereby to decipher mechanisms of these risk factors and potential treatments that target these mechanisms. We envision that the CBTSR will become a national center of excellence in basic and translational stroke research that addresses bench to bed-side to community Issues in stroke. This will be accomplished through the development of junior Investigators to research Independence, and the development of core resources that support the WVU stroke research community, thereby enhancing resources and personnel devoted to stroke research at the WVU to achieve programmatic research activities. Three cores and five research projects are proposed. The Administrative Core will manage the various aspects of the Stroke CoBRE, including an intense junior faculty mentoring program, advisory committees and program evaluation. The Experimental Stroke Core will provide resources, expertise and experimental stroke procedures to junior Investigators as well as to the WVU neuroscience and cardiovascular research community. The Biostatistics Core will provide critical biostatistical support during the design and conduct of the junior Investigator-Initiated projects. The research projects proposed eminate from 5 junior Investigators who are committed to developing independent research programs through the CoBRE mechanism. Collectively, their research projects address the linked areas of stroke prediction, causes, prevention, acute treatment and rehabilitation. The program-as-a-whole has a well-developed and Intensive mentoring program and a rigorous summative and formative evaluation program. Institutional support is also proposed, in the form of faculty hires, facilities construction and monitary contributions.