West Virginia Stroke CoBRE

描述(由申请人提供)：建议是西弗吉尼亚州中风科动物(以下称为中风科动物)，重点是中风的区域。卒中科布雷是作为基础和翻译中风研究中心(CBTSR)的重要组成部分发起的，CBTSR是一个新成立的中心，致力于加强西弗吉尼亚大学(WVU)校园的基础和翻译中风研究，以减轻中风的负担。我们的方法是解决风险因素影响中风的机制，特别是在我们阿巴拉契亚人群中普遍存在的风险因素，从而破译这些风险因素的机制和针对这些机制的潜在治疗方法。我们设想，CBTSR将成为基础和转化性中风研究的全国卓越中心，解决中风中从板凳到床边到社区的问题。这将通过发展初级研究人员以研究独立性，并开发支持西弗吉尼亚大学中风研究社区的核心资源来实现，从而增加西弗吉尼亚大学致力于中风研究的资源和人员，以实现方案研究活动。提出了三个核心和五个研究项目。管理核心将管理中风科布雷的各个方面，包括密集的初级教师指导计划、咨询委员会和计划评估。实验中风核心中心将为初级研究人员以及西弗吉尼亚大学神经科学和心血管研究社区提供资源、专业知识和实验中风程序。生物统计核心将在初级调查员发起的项目的设计和实施期间提供重要的生物统计支助。建议的研究项目来自5名初级调查人员，他们致力于通过科布雷机制制定独立的研究计划。总体而言，他们的研究项目涉及中风预测、病因、预防、急性治疗和康复等相关领域。该计划作为一个整体，有一个完善和密集的指导计划和一个严格的总结性和形成性评估计划。还建议通过聘用教员、设施建设和监测贡献等形式提供机构支持。

DESCRIPTION (provided by applicant): Proposed is the West Virginia Stroke CoBRE (here after called the Stroke CoBRE) with a focus area of stroke. The Stroke CoBRE was initiated as an essential part of the Center for Basic and Translational Stroke Research (CBTSR), a newly formed Center that is focused on enhancing basic and translational stroke research on the West Virginia University (WVU) campus to reduce the burden of stroke. Our approach is to address the mechanisms by which risk factors, particularly prevalent in our Appalachian population, affect stroke and thereby to decipher mechanisms of these risk factors and potential treatments that target these mechanisms. We envision that the CBTSR will become a national center of excellence in basic and translational stroke research that addresses bench to bed-side to community Issues in stroke. This will be accomplished through the development of junior Investigators to research Independence, and the development of core resources that support the WVU stroke research community, thereby enhancing resources and personnel devoted to stroke research at the WVU to achieve programmatic research activities. Three cores and five research projects are proposed. The Administrative Core will manage the various aspects of the Stroke CoBRE, including an intense junior faculty mentoring program, advisory committees and program evaluation. The Experimental Stroke Core will provide resources, expertise and experimental stroke procedures to junior Investigators as well as to the WVU neuroscience and cardiovascular research community. The Biostatistics Core will provide critical biostatistical support during the design and conduct of the junior Investigator-Initiated projects. The research projects proposed eminate from 5 junior Investigators who are committed to developing independent research programs through the CoBRE mechanism. Collectively, their research projects address the linked areas of stroke prediction, causes, prevention, acute treatment and rehabilitation. The program-as-a-whole has a well-developed and Intensive mentoring program and a rigorous summative and formative evaluation program. Institutional support is also proposed, in the form of faculty hires, facilities construction and monitary contributions.