West Virginia Stroke CoBRE

建议的是西弗吉尼亚州中风科动物(这里以后称为中风科动物)，重点领域是 卒中。卒中中心是作为基础和转化性卒中中心的重要组成部分而发起的 研究(CBTSR)，一个新成立的中心，专注于增强基础和转化性中风 西弗吉尼亚大学(WVU)校园内减少中风发病率的研究。我们的方法是 解决风险因素，特别是在我们阿巴拉契亚人群中普遍存在的风险因素影响的机制 从而破译这些危险因素的机制以及针对这些危险因素的潜在治疗方法 机械装置。我们设想，CBTSR将成为全国基础和技术领域的卓越中心 翻译中风研究，解决中风中从板凳到床边到社区的问题。这将是 通过发展初级调查人员来研究独立性，以及 开发支持西弗吉尼亚大学中风研究社区的核心资源，从而增强 西弗吉尼亚大学致力于中风研究的资源和人员以实现计划性研究 活动。提出了三个核心和五个研究项目。管理核心将管理 Stroke Cobre的各个方面，包括密集的初级教师指导计划、咨询 委员会和项目评估。实验卒中核心将提供资源、专业知识和 为初级研究人员以及西弗吉尼亚大学神经科学和 心血管研究社区。生物统计核心将提供关键的生物统计学支持 设计和实施初级调查员发起的项目。建议的研究项目来源于 5名初级调查人员，致力于通过科布雷发展独立研究计划 机制。总体而言，他们的研究项目涉及中风预测、病因、 预防、急诊治疗和康复。作为一个整体，节目有一个发展良好和密集的 指导计划和严格的总结性和形成性评估计划。机构支持也是 建议以教师聘用、设施建设和监测贡献的形式。

Proposed is the West Virginia Stroke CoBRE (here after called the Stroke CoBRE) with a focus area of stroke. The Stroke CoBRE was Initiated as an essential part of the Center for Basic and Translational Stroke Research (CBTSR), a newly formed Center that Is focused on enhancing basic and translational stroke research on the West Virginia University (WVU) campus to reduce the burder of stroke. Our approach Is to address the mechanisms by which risk factors, particularly prevalent in our Appalachian population, affect stroke and thereby to decipher mechanisms of these risk factors and potential treatments that target these mechanisms. We envision that the CBTSR will become a national center of excellence In basic and translational stroke research that addresses bench to bed-side to community Issues in stroke. This will be accomplished through the development of junior Investigators to research Independence, and the development of core resources that support the WVU stroke research community, thereby enhancing resources and personnel devoted to stroke research at the WVU to achieve programmatic research activities. Three cores and five research projects are proposed. The Administrative Core will manage the various aspects of the Stroke CoBRE, including an intense junior faculty mentoring program, advisory committees and program evaluation. The Experimental Stroke Core will provide resources, expertise and experimental stroke procedures to junior Investigators as well as to the WVU neuroscience and cardiovascular research community. The Biostatisitic Core will provide critical biostatistical support during the design and conduct of the junior Investigator-Initiated projects. The research projects proposed eminate from 5 junior Investigators who are committed to developing independent research programs through the CoBRE mechanism. Collectively, their research projects address the linked areas of stroke prediction, causes, prevention, acute treatment and rehabilitation. The program-as-a-whole has a well-developed and Intensive mentoring program and a rigorous summative and formative evaluation program. Institutional support is also proposed, in the form of faculty hires, facilities construction and monitary contributions.