West Virginia Stroke CoBRE

提议的是西弗吉尼亚州中风CoBRE（以下称为中风CoBRE），重点领域为 中风中风CoBRE是作为基础和转化中风中心的重要组成部分而启动的 研究（CBTSR），一个新成立的中心，专注于提高基础和平移中风 西弗吉尼亚大学（WVU）校园的一项研究，以减少中风的负担。我们的做法是 解决风险因素的机制，特别是在我们的阿巴拉契亚人口中普遍存在， 从而解释这些危险因素的机制以及针对这些危险因素的潜在治疗 机制等我们设想，CBTSR将成为一个国家卓越的中心，在基础和 转化中风研究，致力于解决从实验室到床边到社区的中风问题。这将是 通过发展初级研究员来研究独立性， 开发支持WVU中风研究社区的核心资源，从而提高 西弗吉尼亚大学致力于中风研究的资源和人员，以实现项目研究 活动提出了三个核心和五个研究项目。行政核心将管理 中风科博雷的各个方面，包括一个激烈的初级教师辅导计划，咨询 委员会和方案评估。实验中风核心将提供资源，专业知识和 向初级研究者以及西弗吉尼亚大学神经科学和 心血管研究社区。生物统计核心将在 设计和实施初级研究者发起的项目。提出的研究项目来自 5名致力于通过CoBRE开发独立研究项目的初级研究者 机制总的来说，他们的研究项目涉及中风预测，原因， 预防、急性治疗和康复。该计划作为一个整体有一个发达和密集的 指导计划和严格的总结性和形成性评估计划。机构支持也是 建议，在教师招聘，设施建设和monitorary贡献的形式。

Proposed is the West Virginia Stroke CoBRE (here after called the Stroke CoBRE) with a focus area of stroke. The Stroke CoBRE was Initiated as an essential part of the Center for Basic and Translational Stroke Research (CBTSR), a newly formed Center that Is focused on enhancing basic and translational stroke research on the West Virginia University (WVU) campus to reduce the burder of stroke. Our approach Is to address the mechanisms by which risk factors, particularly prevalent in our Appalachian population, affect stroke and thereby to decipher mechanisms of these risk factors and potential treatments that target these mechanisms. We envision that the CBTSR will become a national center of excellence In basic and translational stroke research that addresses bench to bed-side to community Issues in stroke. This will be accomplished through the development of junior Investigators to research Independence, and the development of core resources that support the WVU stroke research community, thereby enhancing resources and personnel devoted to stroke research at the WVU to achieve programmatic research activities. Three cores and five research projects are proposed. The Administrative Core will manage the various aspects of the Stroke CoBRE, including an intense junior faculty mentoring program, advisory committees and program evaluation. The Experimental Stroke Core will provide resources, expertise and experimental stroke procedures to junior Investigators as well as to the WVU neuroscience and cardiovascular research community. The Biostatisitic Core will provide critical biostatistical support during the design and conduct of the junior Investigator-Initiated projects. The research projects proposed eminate from 5 junior Investigators who are committed to developing independent research programs through the CoBRE mechanism. Collectively, their research projects address the linked areas of stroke prediction, causes, prevention, acute treatment and rehabilitation. The program-as-a-whole has a well-developed and Intensive mentoring program and a rigorous summative and formative evaluation program. Institutional support is also proposed, in the form of faculty hires, facilities construction and monitary contributions.