Training Program in Translational Neuromodulation

项目摘要 神经调节是一个快速发展的研究领域，包括广泛的神经技术， 可以操纵神经回路来治疗神经系统疾病。加快临床转化， 神经调节疗法，迫切需要培养下一代科学家，工程师， 拥有知识库和电路询问工具来研究神经系统疾病的临床医生， 神经调节如何影响神经组织的原则性生物物理理解， 在多学科团队中工作的科学技能，以及驾驭翻译途径的能力 将新的发现和技术应用于临床实践。T32项目的使命是 培养一批多元化的博士后研究员，为他们提供世界一流的发展机会， 翻译神经调节技术，并作为该领域的下一代领导者开始他们的职业生涯 转化神经调节研究该培训计划将配对博士后研究员与教师合作， 来自（1）基础神经科学或神经工程领域和（2）临床学科的导师。研究员将 与项目教师一起进行转化研究，他们是（a）深部脑临床转化的先驱 用于神经和神经精神障碍的刺激疗法，（B）用于损伤后的脊髓刺激 恢复自主运动和自主功能，（c）外周神经刺激治疗 心脏代谢和炎性疾病，和（d）用于操纵脑癌扩散的技术。 研究员将参加临床沉浸，并有机会整合和领导的方面， 已经进入人体临床试验或接近首次人体研究门槛的研究项目。的 培训计划还将聘请一批住院医师或研究员级别的医生（“临床助理”），他们 可以投入一年的受保护和已经资助的研究时间。所有学员将进一步发展他们的技能 在严格的统计数据分析，实验设计方法，研究质量保证， 通过实践研讨会负责任地进行研究。我们还将培训一批研究员， 通过翻译和商业化训练营与后续研讨会会议，与临床助理合作。 该计划将利用优秀的翻译神经调节研究计划和设施， 明尼苏达大学，并将我们的研究员融入明尼苏达州独特的医疗设备生态系统， 这里是许多开发神经调节技术的全球医疗技术公司的所在地。

PROJECT SUMMARY Neuromodulation is a rapidly growing field of study that encompasses a wide spectrum of neurotechnology that can manipulate neural circuits for treating nervous system disorders. To accelerate clinical translation of neuromodulation therapies, there is a strong need to train the next generation of scientists, engineers, and clinicians who have the knowledge base and circuit-interrogating tools to investigate nervous system disorders, the principled biophysical understanding of how neuromodulation affects neural tissue, the communication and scientific skills to work in multi-disciplinary teams, and the ability to navigate the translational pathways necessary to bring new discoveries and technologies to clinical practice. The mission of this T32 program is to train a diverse group of post-doctoral fellows, provide them with world-class opportunities to develop and translate neuromodulation technologies, and launch their careers as the next generation of leaders in the field of translational neuromodulation research. The training program will pair post-doctoral fellows with faculty co- mentors from (1) fundamental neuroscience or neuroengineering fields and (2) clinical disciplines. Fellows will conduct translational research with program faculty who are pioneers in the clinical translation of (a) deep brain stimulation therapies for neurological and neuropsychiatric disorders, (b) spinal cord stimulation for post-injury restoration of volitional movement and autonomic function, (c) peripheral nerve stimulation for treatment of cardiometabolic and inflammatory disorders, and (d) techniques for manipulating the spread of brain cancer. Fellows will participate in a clinical immersion and have the opportunity to integrate and lead aspects of research projects that are already in human clinical trials or near the threshold for first-in-human studies. The training program will also engage a cohort of resident- or fellowship-level physicians (“clinical associates”) who can devote one year of protected and already funded research time. All trainees will further develop their skills in rigorous statistical data analysis, experimental design methodologies, research quality assurance, and responsible conduct of research through hands-on workshops. We will also train the cohort of fellows and clinical associates through a translation and commercialization bootcamp with follow-up workshop sessions. This program will tap into outstanding translational neuromodulation research programs and facilities at the University of Minnesota and integrate our fellows into the unique medical device ecosystem of Minnesota, which is home to many global medtech companies that are developing neuromodulation technologies.