Training Program in Translational Neuromodulation

转化神经调节培训计划

• 批准号: 10659148
• 负责人: Matthew Douglas Johnson
• 金额: $ 35.82万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10659148
• 关键词: Training Programs; neuroregulation

PROJECT SUMMARY Neuromodulation is a rapidly growing field of study that encompasses a wide spectrum of neurotechnology that can manipulate neural circuits for treating nervous system disorders. To accelerate clinical translation of neuromodulation therapies, there is a strong need to train the next generation of scientists, engineers, and clinicians who have the knowledge base and circuit-interrogating tools to investigate nervous system disorders, the principled biophysical understanding of how neuromodulation affects neural tissue, the communication and scientific skills to work in multi-disciplinary teams, and the ability to navigate the translational pathways necessary to bring new discoveries and technologies to clinical practice. The mission of this T32 program is to train a diverse group of post-doctoral fellows, provide them with world-class opportunities to develop and translate neuromodulation technologies, and launch their careers as the next generation of leaders in the field of translational neuromodulation research. The training program will pair post-doctoral fellows with faculty co- mentors from (1) fundamental neuroscience or neuroengineering fields and (2) clinical disciplines. Fellows will conduct translational research with program faculty who are pioneers in the clinical translation of (a) deep brain stimulation therapies for neurological and neuropsychiatric disorders, (b) spinal cord stimulation for post-injury restoration of volitional movement and autonomic function, (c) peripheral nerve stimulation for treatment of cardiometabolic and inflammatory disorders, and (d) techniques for manipulating the spread of brain cancer. Fellows will participate in a clinical immersion and have the opportunity to integrate and lead aspects of research projects that are already in human clinical trials or near the threshold for first-in-human studies. The training program will also engage a cohort of resident- or fellowship-level physicians (“clinical associates”) who can devote one year of protected and already funded research time. All trainees will further develop their skills in rigorous statistical data analysis, experimental design methodologies, research quality assurance, and responsible conduct of research through hands-on workshops. We will also train the cohort of fellows and clinical associates through a translation and commercialization bootcamp with follow-up workshop sessions. This program will tap into outstanding translational neuromodulation research programs and facilities at the University of Minnesota and integrate our fellows into the unique medical device ecosystem of Minnesota, which is home to many global medtech companies that are developing neuromodulation technologies.

项目总结 神经调节是一个快速发展的研究领域，它涵盖了广泛的神经技术， 可以操纵神经回路来治疗神经系统疾病。以加速临床翻译 神经调节疗法，迫切需要培养下一代科学家、工程师和 拥有调查神经系统疾病的知识库和电路询问工具的临床医生， 对神经调节如何影响神经组织、沟通和 在多学科团队中工作的科学技能，以及在翻译过程中导航的能力 有必要将新发现和新技术带到临床实践中。这个T32计划的使命是 培养一批多元化的博士后研究员，为他们提供世界级的发展和 翻译神经调节技术，开启他们作为该领域下一代领导者的职业生涯 翻译神经调节研究的最新进展。该培训计划将把博士后研究员与教员联合 来自(1)基础神经科学或神经工程领域和(2)临床学科的导师。研究员们会 与临床翻译(A)脑深部的先驱计划教员进行翻译研究 神经和神经精神障碍的刺激疗法；(B)损伤后的脊髓刺激 恢复自主运动和自主神经功能；(C)周围神经刺激治疗 心脏代谢和炎症性疾病，以及(D)控制脑癌扩散的技术。 研究员将参与临床沉浸，并有机会整合和领导以下各方面 已经在进行人体临床试验或接近首次人体试验门槛的研究项目。这个 培训计划还将聘用一批住院医师或研究员级别的医生(“临床助理”)，他们将 可以投入一年的受保护和已经资助的研究时间。所有学员都将进一步发展自己的技能 在严格的统计数据分析、实验设计方法、研究质量保证和 通过实践研讨会负责任地进行研究。我们还将培训一批研究员和 通过翻译和商业化训练营和后续研讨会培训临床助理。 该计划将利用优秀的翻译神经调节研究计划和设施，位于 并将我们的研究人员整合到明尼苏达州独特的医疗设备生态系统中， 它是许多正在开发神经调节技术的全球医疗科技公司的大本营。