Spatiotemporal optimization of deep brain stimulation for Parkinson's Disease
帕金森病脑深部刺激的时空优化
基本信息
- 批准号:9278298
- 负责人:
- 金额:$ 53.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-07-01 至 2021-06-30
- 项目状态:已结题
- 来源:
- 关键词:AcuteAffectAlgorithmsAnimalsAreaBasal GangliaBehavioralBradykinesiaBrainBrain StemCell NucleusClinicalComplementary therapiesComputer SimulationCoupledCouplingDataDeep Brain StimulationDevelopmentDopamineDrug-Induced DyskinesiaElectric StimulationElectrodesElectrophysiology (science)FrequenciesFunctional disorderFutureGaitGlobus PallidusHigh Frequency OscillationImpairmentImplantIndividualInjection of therapeutic agentInternal CapsuleLeadMagnetic Resonance ImagingMicroelectrodesModelingMonkeysMotorMotor CortexMotor PathwaysMuscle ContractionNeurotoxinsParkinson DiseaseParkinsonian DisordersPathologicPathway interactionsPatientsPatternPharmaceutical PreparationsPhasePhysiologicalProcessReplacement TherapySeveritiesSiteStimulusStructureStructure of subthalamic nucleusSymptomsTechnologyTestingThalamic structureTherapeuticTherapeutic EffectTimeTranslatingTranslationsTreatment EfficacyTremorbasebehavioral outcomedensityexperimental studyimprovedindividual patientmotor controlnonhuman primatenovelnovel strategiessignal processingspatiotemporalsymptomatologytargeted treatment
项目摘要
PROJECT SUMMARY AND ABSTRACT
The basal ganglia have a rich, functional topography composed of motor subcircuits and oscillatory networks
that are thought to be critically important to the pathophysiology of Parkinson's disease (PD) and the
successful application of deep brain stimulation therapy (DBS) in managing each cardinal motor sign of PD.
There is a strong clinical need to better understand these processes and in turn harness them to deliver
therapy that is tailored to an individual patient and a patient's own symptomatology. In this project, we seek to
develop a novel spatiotemporally optimized DBS therapy and evaluate its efficacy in a non-human primate
model of PD. The optimization approach leverages the unique capabilities of (1) high-field MR imaging (7T and
10.5T), (2) subject-specific computational models of DBS, (3) a high-density DBS lead with electrodes
arranged along and around the lead shank, and (4) a real-time signal processing interface that can readily
adapt stimulation parameters on the DBS array based on analysis of ongoing oscillatory activity at and
downstream of the site of stimulation. High-density DBS arrays spanning the subthalamic nucleus (STN) and
thalamic fasciculus (Array A) and the external and internal globus pallidus (GP) (Array B) will be implanted in
each subject. Aim 1 will characterize the magnitude and time course of therapeutic effects on each
parkinsonian motor sign when targeting electrical stimulation within and around the STN and GP. Aim 2 will
investigate how targeted stimulation differentially affects oscillatory activity at and downstream of the site of
stimulation and relates to improvement in each parkinsonian motor sign. Aim 3 will develop and apply a novel
set of optimization algorithms, including chaotic desynchronization and real-time closed-loop phasic
stimulation, to test the hypothesis that optimizing suppression of exaggerated phase amplitude coupling in the
STN and GP will further increase the overall magnitude of DBS therapy. Together, this project will enhance our
understanding of the pathophysiology of PD and provide critical data towards translating a patient-optimized
DBS therapy that integrates high-density DBS leads with novel closed-loop stimulation.
项目总结与摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Matthew Douglas Johnson其他文献
Matthew Douglas Johnson的其他文献
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{{ truncateString('Matthew Douglas Johnson', 18)}}的其他基金
Training Program in Translational Neuromodulation
转化神经调节培训计划
- 批准号:
10412589 - 财政年份:2022
- 资助金额:
$ 53.59万 - 项目类别:
Training Program in Translational Neuromodulation
转化神经调节培训计划
- 批准号:
10659148 - 财政年份:2022
- 资助金额:
$ 53.59万 - 项目类别:
A novel electroceutical tool for treatment of kidney-based diseases
一种治疗肾脏疾病的新型电疗法工具
- 批准号:
10455432 - 财政年份:2021
- 资助金额:
$ 53.59万 - 项目类别:
Optimizing pallidofugal modulation of midbrain and thalamic nuclei for treating cognitive-motor signs of Parkinson's disease
优化中脑和丘脑核的苍白球调节以治疗帕金森病的认知运动体征
- 批准号:
10282964 - 财政年份:2021
- 资助金额:
$ 53.59万 - 项目类别:
A novel electroceutical tool for treatment of kidney-based diseases
一种治疗肾脏疾病的新型电疗法工具
- 批准号:
10194764 - 财政年份:2021
- 资助金额:
$ 53.59万 - 项目类别:
Optimizing pallidofugal modulation of midbrain and thalamic nuclei for treating cognitive-motor signs of Parkinson's disease
优化中脑和丘脑核的苍白球调节以治疗帕金森病的认知运动体征
- 批准号:
10489838 - 财政年份:2021
- 资助金额:
$ 53.59万 - 项目类别:
Optimizing pallidofugal modulation of midbrain and thalamic nuclei for treating cognitive-motor signs of Parkinson's disease
优化中脑和丘脑核的苍白球调节以治疗帕金森病的认知运动体征
- 批准号:
10703249 - 财政年份:2021
- 资助金额:
$ 53.59万 - 项目类别:
Spatiotemporal Optimization of Deep Brain Stimulation for Parkinson's Disease
帕金森病脑深部刺激的时空优化
- 批准号:
10680463 - 财政年份:2016
- 资助金额:
$ 53.59万 - 项目类别:
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