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Structural Connections Core

结构连接核心

基本信息

批准号：
10411712
负责人：
Anastasia Yendiki
金额：
$ 35.33万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-06-01 至 2027-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10411712
关键词：
Adopted Affect Aftercare Anatomy Anterior Axon Brain Brain Mapping Collaborations Corpus Callosum Corpus striatum structure Data Data Analyses Development Diffusion Diffusion Magnetic Resonance Imaging Dorsal Exhibits Funding Goals Human Individual Injections Insula of Reil Internal Capsule Intervention Label Limb structure Longitudinal Studies MRI Scans Macaca Maps Measures Methods Modality Morphologic artifacts Noise Pathway interactions Patients Positioning Attribute Prefrontal Cortex Protocols documentation Resolution Role Scanning Seeds Signal Transduction Techniques Therapeutic Intervention Tracer Translating Travel Work analysis pipeline anatomical tracing base brain circuitry brain pathway cingulate cortex data acquisition data analysis pipeline data integration design human data human subject in vivo insight interest neural circuit neuroimaging nonhuman primate quality assurance reconstruction tool tractography white matter

项目摘要

Project summary: The goal of Core B (Structural Connections Core) is to provide support for mapping brain pathways relevant to the OCD network, in non-human primates and human subjects. This involves bridging between projects to translate information from anatomical tracing studies to neuroimaging studies that utilize diffusion MRI. The first aim of Core B is to collect diffusion MRI data with very high resolution and signal-to- noise ratio on post mortem macaque brains that have previously received tracer injections for P1; and to use these data to determine which of the pathways identified by diffusion tractography are accurate and which are artifacts due to the inherent limitations of diffusion MRI. The second aim of core B is to use the insights generated from the aforementioned macaque studies to guide the analysis of diffusion MRI data from human subjects in P3-5. Core B will provide these projects with optimized data processing pipelines for mapping the pathways likely to be involved in OCD, with the ultimate goal of investigating how these pathways differ between patients and healthy controls (P3), and how they are affected by noninvasive or invasive interventions (P4-5). Core B will advise the projects on all aspects of diffusion MRI data acquisition, quality assurance, and analyses to reconstruct and characterize bundles of the OCD network.

项目概述：核心B(Structure Connections Core)的目标是为绘制大脑图谱提供支持在非人类灵长类动物和人类受试者中，与强迫症网络相关的通路。这涉及到桥接在将信息从解剖追踪研究转化为神经成像研究的项目之间弥散磁共振成像。核心B的第一个目标是以非常高的分辨率和信号比收集扩散磁共振数据以前接受过P1示踪剂注射的死后猕猴大脑的噪声比率；并使用这些数据用来确定弥散纤维束造影术确定的哪些路径是准确的，哪些是磁共振弥散成像固有的局限性造成的伪影。核心B的第二个目标是使用洞察力从前述猕猴研究中产生，以指导分析来自人类的弥散磁共振数据三至五年级的受试者。核心B将为这些项目提供优化的数据处理管道，以绘制可能涉及强迫症的途径，最终目标是调查这些途径的不同之处患者和健康对照组之间的差异(P3)，以及非侵入性或侵入性干预对他们的影响 (P4-5)。核心B将就扩散磁共振成像数据获取、质量保证和分析重建和表征强迫症网络的捆绑。