Structural Connections Core

结构连接核心

基本信息

批准号：
10411712
负责人：
Anastasia Yendiki
金额：
$ 35.33万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-06-01 至 2027-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10411712
关键词：
Adopted Affect Aftercare Anatomy Anterior Axon Brain Brain Mapping Collaborations Corpus Callosum Corpus striatum structure Data Data Analyses Development Diffusion Diffusion Magnetic Resonance Imaging Dorsal Exhibits Funding Goals Human Individual Injections Insula of Reil Internal Capsule Intervention Label Limb structure Longitudinal Studies MRI Scans Macaca Maps Measures Methods Modality Morphologic artifacts Noise Pathway interactions Patients Positioning Attribute Prefrontal Cortex Protocols documentation Resolution Role Scanning Seeds Signal Transduction Techniques Therapeutic Intervention Tracer Translating Travel Work analysis pipeline anatomical tracing base brain circuitry brain pathway cingulate cortex data acquisition data analysis pipeline data integration design human data human subject in vivo insight interest neural circuit neuroimaging nonhuman primate quality assurance reconstruction tool tractography white matter

项目摘要

Project summary: The goal of Core B (Structural Connections Core) is to provide support for mapping brain pathways relevant to the OCD network, in non-human primates and human subjects. This involves bridging between projects to translate information from anatomical tracing studies to neuroimaging studies that utilize diffusion MRI. The first aim of Core B is to collect diffusion MRI data with very high resolution and signal-to- noise ratio on post mortem macaque brains that have previously received tracer injections for P1; and to use these data to determine which of the pathways identified by diffusion tractography are accurate and which are artifacts due to the inherent limitations of diffusion MRI. The second aim of core B is to use the insights generated from the aforementioned macaque studies to guide the analysis of diffusion MRI data from human subjects in P3-5. Core B will provide these projects with optimized data processing pipelines for mapping the pathways likely to be involved in OCD, with the ultimate goal of investigating how these pathways differ between patients and healthy controls (P3), and how they are affected by noninvasive or invasive interventions (P4-5). Core B will advise the projects on all aspects of diffusion MRI data acquisition, quality assurance, and analyses to reconstruct and characterize bundles of the OCD network.

项目摘要：核心B（结构连接核心）的目标是为映射大脑提供支持与OCD网络，非人类灵长类动物和人类受试者有关的途径。这涉及桥接在项目之间将信息从解剖学跟踪研究转化为利用的神经影像学研究扩散MRI。核B的第一个目的是收集以非常高的分辨率和信噪比的扩散MRI数据先前接受过P1注射示踪剂的遗迹大脑的噪声比；并使用这些数据以确定通过扩散拖拉学标识的哪些途径准确，哪些是由于扩散MRI的固有局限性引起的伪影。核心B的第二个目的是使用见解由上述猕猴研究产生，以指导人类扩散MRI数据的分析 P3-5中的受试者。核心B将为这些项目提供优化的数据处理管道，以映射可能参与强迫症的途径，其最终目的是研究这些途径如何不同在患者和健康对照（P3）之间，以及如何受到无创或侵入性干预措施的影响（P4-5）。核心B将就扩散MRI数据获取，质量保证和的各个方面的各个方面提供建议分析以重建和表征OCD网络的捆绑包。