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Structural Connections Core

结构连接核心

基本信息

批准号：
10594021
负责人：
Anastasia Yendiki
金额：
$ 34.09万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-06-01 至 2027-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10594021
关键词：
Adopted Affect Aftercare Anatomy Anterior Autopsy Axon Brain Brain Mapping Collaborations Corpus Callosum Corpus striatum structure Data Data Analyses Development Diffusion Diffusion Magnetic Resonance Imaging Dorsal Exhibits Funding Goals Human Individual Injections Insula of Reil Internal Capsule Intervention Label Limb structure Longitudinal Studies MRI Scans Macaca Maps Measures Methods Modality Morphologic artifacts Noise Pathway interactions Patients Positioning Attribute Prefrontal Cortex Protocols documentation Resolution Role Scanning Signal Transduction Techniques Therapeutic Intervention Tracer Translating Travel Work analysis pipeline anatomical tracer anatomical tracing brain circuitry brain pathway cingulate cortex data acquisition data analysis pipeline data integration design human data human subject in vivo insight interest neural circuit neuroimaging nonhuman primate quality assurance reconstruction tool tractography white matter

项目摘要

Project summary: The goal of Core B (Structural Connections Core) is to provide support for mapping brain pathways relevant to the OCD network, in non-human primates and human subjects. This involves bridging between projects to translate information from anatomical tracing studies to neuroimaging studies that utilize diffusion MRI. The first aim of Core B is to collect diffusion MRI data with very high resolution and signal-to- noise ratio on post mortem macaque brains that have previously received tracer injections for P1; and to use these data to determine which of the pathways identified by diffusion tractography are accurate and which are artifacts due to the inherent limitations of diffusion MRI. The second aim of core B is to use the insights generated from the aforementioned macaque studies to guide the analysis of diffusion MRI data from human subjects in P3-5. Core B will provide these projects with optimized data processing pipelines for mapping the pathways likely to be involved in OCD, with the ultimate goal of investigating how these pathways differ between patients and healthy controls (P3), and how they are affected by noninvasive or invasive interventions (P4-5). Core B will advise the projects on all aspects of diffusion MRI data acquisition, quality assurance, and analyses to reconstruct and characterize bundles of the OCD network.

项目概述：Core B（结构连接核心）的目标是为映射大脑提供支持在非人类灵长类动物和人类受试者中，与OCD网络相关的通路。这涉及到桥接将解剖追踪研究的信息转化为神经成像研究的项目之间，弥散磁共振成像核心B的首要目标是收集具有极高分辨率和信号-时间比的弥散MRI数据。噪声比对死后猕猴大脑先前已接受示踪剂注射P1;并使用这些数据，以确定哪些途径所确定的扩散纤维束成像是准确的，由于弥散MRI的固有局限性而产生的伪影。核心B的第二个目标是利用洞察力从上述猕猴研究中产生，以指导来自人类的扩散MRI数据的分析在P3-5的主题。核心B将为这些项目提供优化的数据处理管道，可能参与强迫症的途径，最终目标是研究这些途径的不同之处患者和健康对照之间的差异（P3），以及他们如何受到非侵入性或侵入性干预的影响（P4-5）。核心B将就弥散MRI数据采集、质量保证和分析以重构和表征OCD网络的束。