Methods for Early Phase Translation of Basic Science into Behavioral Treatments to Improve Health

项目摘要 加强行为干预以改善健康，如癌症预防和治疗， 为了提高其在临床实践中的推广，需要：（1）更多地关注T1期 从基础行为和社会科学研究到应用行为干预的转变 （2）通过促进使用新的治疗方法，更多地关注早期治疗方法的开发 和创新的方法来回答有关基本治疗设计的常见问题。这 技能发展课程的目的是培训100名干预科学家（研究员）， 他们对针对癌症和相关健康的行为治疗开发感兴趣， 行为。培训将持续6个月，包括为期3天的研讨会，然后每两周进行一次 每届25名研究员的网络研讨会。学习将是多方向的，并将以说教为特色， 互动和应用教学技术。培训员培训模式贯穿于 当然了可选的后续活动包括与教师的咨询和指导。课程将 由专家教师提供，他们将教授干预发展的分阶段方法，新的和 创新的方法，非常适合回答健康行为过程中出现的常见问题， 治疗发展。这些方法包括剂量探索方法、混合方法， 最大限度地提高处理的生态有效性，小样本方法，剪裁和适应性 治疗和方法，以确定时间和选择适当的对照组。具体 本课程的目标是：1）成功招募并培养100名致力于行为研究的研究员 4年来与癌症预防/治疗和相关健康行为相关的干预措施 （2）增加少数民族的技能， 研究员在一个分阶段的方法，与相关的创新方法和设计的T1翻译 BSSR。3)对技能发展课程的成功进行持续评估， 基于三个基本度量：（a）感知价值;（B）基于网站点击的课程的覆盖范围， 申请人数，以及培训培训员的活动;以及（c）课程对职业生涯的影响 研究员的发展轨迹（出版物、赠款）。4)进行持续的课程开发， 改进，以及通过技术传播，根据定量和定性的结果， 评估和赠款期间出现的新方法。

PROJECT SUMMARY To strengthen behavioral interventions for improve health, as in cancer prevention and treatment, and increase their dissemination into clinical practice, what is needed is: (1) more attention to phased T1 translation from basic behavioral and social sciences research to applied behavioral intervention development; and (2) more focus on early-phase treatment development by promoting the use of new and innovative methodologies to answer commonly asked questions about basic treatment design. This skills development course aims to train 100 intervention scientists (Fellows) at any academic rank but who have an interest in behavioral treatment development to target cancer and related health behaviors. Training will take place over 6 months including a 3-day workshop followed by bi weekly webinars with 25 Fellows per session. Learning will be multi-directional and will feature didactic, interactive, and applied teaching techniques. A train-the-trainer model is integrated throughout the course. Optional follow-up activities include consultation and mentoring with faculty. The curriculum will be offered by expert faculty who will teach a phased approach to intervention development, new and innovative methods that are well-suited to answer common questions that arise during health behavior treatment development. Among the methodologies are dose-finding methods, mixed methods to maximize ecological validity of treatments, approaches for small samples, tailoring and adaptive treatments, and methods to determine the timing and choice of appropriate control groups. The Specific Aims of the course are: 1) To successfully recruit and train 100 Fellows dedicated to behavioral interventions relevant for cancer prevention/treatment and related health behaviors over the 4-year grant period, with substantial minority representation (25 Fellows per year); 2) To increase the skills of Fellows in a phased approach, with associated innovative methods and designs for T1 translation of BSSR. 3) To conduct an ongoing evaluation of the success of the skills development course based upon three basic metrics: (a) perceived value; (b) the reach of the course based upon website hits, number of applications, and train the trainer activities; and (c) the impact of the course on the career trajectories of the Fellows (publications, grants). 4) To conduct ongoing curriculum development and refinement, as well as dissemination via technology, based upon results of quantitative and qualitative evaluations and new methodologies emerging over the grant period.