Methods for Early Phase Translation of Basic Science into Behavioral Treatments to Improve Health

项目总结 加强行为干预以改善健康，例如在癌症预防和治疗方面，以及 增加其在临床实践中的推广，需要的是：(1)更多地关注阶段性T1 从基础行为和社会科学研究到应用行为干预的转换 开发；和(2)通过推广使用新的药物，更加注重早期治疗的开发 以及回答有关基本治疗设计的常见问题的创新方法。这 技能发展课程的目标是培养100名干预科学家(研究员)，在任何学术级别 对针对癌症和相关健康的行为治疗开发感兴趣的人 行为。培训将在6个月内进行，包括为期3天的研讨会，然后是双周培训。 每期有25名研究员参加的网络研讨会。学习将是多方向的，将以说教为特色， 互动式、应用型教学技巧。培训培训员的模式在整个 当然了。可选的后续活动包括与教职员工进行咨询和指导。课程设置将 由专家教员提供，他们将教授干预开发的分阶段方法、新的和 非常适合回答健康行为中出现的常见问题的创新方法 治疗的发展。在这些方法中，有剂量发现方法，混合方法来 最大限度地提高治疗的生态有效性，针对小样本、量身定制和适应性的方法 治疗，以及确定适当对照组的时机和选择的方法。具体的 该课程的目标是：1)成功招聘和培训100名致力于行为研究的研究员 4年来癌症防治相关干预措施及相关健康行为 补助金期间，有大量少数族裔代表(每年25名研究员)；2)提高 采用分阶段方法，为T1翻译提供相关的创新方法和设计 BSSR。3)对技能发展课程的成功情况进行持续评估 根据三个基本指标：(A)感知价值；(B)基于网站点击量的课程覆盖范围， 申请人数，并培训培训员活动；(C)课程对职业生涯的影响 研究员的发展轨迹(出版物、赠款)。4)进行持续的课程开发和 改进，以及通过技术传播，基于数量和质量的结果 在赠款期间出现的评价和新方法。

PROJECT SUMMARY To strengthen behavioral interventions for improve health, as in cancer prevention and treatment, and increase their dissemination into clinical practice, what is needed is: (1) more attention to phased T1 translation from basic behavioral and social sciences research to applied behavioral intervention development; and (2) more focus on early-phase treatment development by promoting the use of new and innovative methodologies to answer commonly asked questions about basic treatment design. This skills development course aims to train 100 intervention scientists (Fellows) at any academic rank but who have an interest in behavioral treatment development to target cancer and related health behaviors. Training will take place over 6 months including a 3-day workshop followed by bi weekly webinars with 25 Fellows per session. Learning will be multi-directional and will feature didactic, interactive, and applied teaching techniques. A train-the-trainer model is integrated throughout the course. Optional follow-up activities include consultation and mentoring with faculty. The curriculum will be offered by expert faculty who will teach a phased approach to intervention development, new and innovative methods that are well-suited to answer common questions that arise during health behavior treatment development. Among the methodologies are dose-finding methods, mixed methods to maximize ecological validity of treatments, approaches for small samples, tailoring and adaptive treatments, and methods to determine the timing and choice of appropriate control groups. The Specific Aims of the course are: 1) To successfully recruit and train 100 Fellows dedicated to behavioral interventions relevant for cancer prevention/treatment and related health behaviors over the 4-year grant period, with substantial minority representation (25 Fellows per year); 2) To increase the skills of Fellows in a phased approach, with associated innovative methods and designs for T1 translation of BSSR. 3) To conduct an ongoing evaluation of the success of the skills development course based upon three basic metrics: (a) perceived value; (b) the reach of the course based upon website hits, number of applications, and train the trainer activities; and (c) the impact of the course on the career trajectories of the Fellows (publications, grants). 4) To conduct ongoing curriculum development and refinement, as well as dissemination via technology, based upon results of quantitative and qualitative evaluations and new methodologies emerging over the grant period.