Posterior cingulate cortex and executive control of episodic memory

后扣带皮层和情景记忆的执行控制

• 批准号: 10420112
• 负责人: Brett Foster
• 金额: $ 72.88万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10420112
• 关键词: Alzheimer' s Disease; Anatomy; Animal Model; Area; Behavior; Behavioral; Brain; Cerebral cortex; Cognitive; Complex; Consensus; Data; Disease; Dissociation; Dorsal; Electric Stimulation; Electrophysiology (science); Elements; Episodic memory; Event; Evoked Potentials; Failure; Fostering; Frequencies; Functional disorder; Goals; Hippocampus (Brain); Homologous Gene; Human; Human Characteristics; Infrastructure; Literature; Location; Maps; Measures; Medial; Memory; Memory impairment; Mental Depression; Metabolism; Modeling; Monkeys; Nerve Degeneration; Neurodegenerative Disorders; Neurons; Patients; Perception; Play; Population; Primates; Process; Regulation; Research; Retrieval; Rodent; Role; Schizophrenia; Signal Transduction; Site; System; Temporal Lobe; Testing; base; behavior test; cingulate cortex; cognitive function; common symptom; design; executive function; experience; experimental study; human model; insight; learned behavior; memory encoding; memory process; memory retrieval; multisensory; neuroimaging; news; nonhuman primate; novel; relating to nervous system; response

Project Summary Episodic memory involves the encoding and retrieval of past experiences to support learned behavior. Aside from these mnemonic processes, it also requires the ability to regulate memory (i.e. executive processes). For example, many real-world decisions will engage episodic retrieval, for which executive processes must help to integrate and evaluate the quality of remembered information (mnemonic evidence) and guide behavior to either decision, action, or continued memory search. While the neural basis of episodic memory encoding and retrieval have been a major focus of research, far less is known about its executive aspects. Executive mnemonic functions likely involve an anatomical substrate that is (i) multisensory/associative, (ii) engaged by memory/executive processing, and (iii) strongly interconnected with both mnemonic regions in the medial temporal lobe (MTL) and executive prefrontal (PFC) regions. Prior non-human primate studies, as well as human electrophysiology and neuroimaging data, suggest that posterior cingulate cortex (PCC) fulfills these criteria. Our central hypothesis is that the PCC plays a critical and unique role in executive control of episodic memory retrieval. We further hypothesize that it comprises three subregions regions: dorsal PCC, ventral PCC and retrosplenial cortex (RSC). These subregions are proposed to play complementary roles, corresponding to retrieval regulation, retrieval integration, and scene perception and transformation, respectively. In this account, PCC is a convergence zone of memory and executive systems, whose specific functional organization accounts for prior discrepancies between studies and species. Here, we utilize human intracranial recordings, including single unit data and stimulation within PCC, to better resolve the functional organization of this region. We will therefore employ an array of cognitive experiments to delineate three PCC subregions supporting the encoding, retrieval and executive control of memory processing (Aim 1). In delineating these subregions, we will also seek to differentiate PCC responses from those occurring in memory (MTL) and executive (dlPFC & ACC) functional networks (Aim 2). Finally, based on these observations, we will demonstrate the causal role of PCC subregions on behavior and local/network activity (Aim 3). By studying PCC, a convergence zone of memory and executive systems, progress can be made in elucidating how the failure to successfully leverage past experiences in daily behavior can occur as a common symptom of both neurodegenerative disease (e.g. Alzheimer’s disease) and multiple psychiatric conditions (e.g. schizophrenia) implicating PCC dysfunction.

项目总结