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Sensory Reinstatement in Human Neocortex

人类新皮质的感觉恢复

基本信息

批准号：
10401843
负责人：
Brett Foster
金额：
$ 40.63万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-14 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10401843
关键词：
Address Anatomy Area Attention Auditory Behavior Behavioral Biological Models Brain Categories Conscious Cues Data Deja Vu Electric Stimulation Electrical Stimulation of the Brain Electrocorticogram Episodic memory Event Face Face Processing Familiarity Frequencies Hallucinations Hippocampus (Brain)Human Measures Memory Methodology Methods Nature Neocortex Participant Pattern Perception Play Population Post-Traumatic Stress Disorders Process Property Psyche structure Psychoses Publishing Reporting Retrieval Role Schizophrenia Sensory Sensory Hallucinations Stimulus Testing Visual Visual Cortex Visual system structure Work area striata base behavioral response density experience face perception fusiform face area improved insight memory process memory retrieval neocortical neuroimaging novel relating to nervous system response sensory cortex sensory input spatiotemporal visual imagery visual memory

项目摘要

Episodic memory involves consciously remembering past events often with an impressive degree of perceptual detail. How is the brain able to recreate prior perceptual states without the necessary sensory inputs? A long- held view is that consciously remembering a stimulus requires reactivation of activity patterns associated with the perception of that stimulus. This process of neocortical `sensory reinstatement' is thought to be dependent on the hippocampus, a region critical for episodic memory. Consequently, there has been an overwhelming empirical focus on studying reinstatement activities within the hippocampus. However, if sensory reinstatement in neocortex is a critical part of episodic memory retrieval, it must be empirically shown to be a spatially and temporally precise recapitulation of sensory processing, and to causally contribute to memory behavior. To date, the best evidence of sensory reinstatement in human neocortex has come from neuroimaging studies reporting spatial overlap or similarity of brain responses for perceiving and retrieving stimuli. While informative, such data: i) do not consistently show overlap in expected sensory cortices; ii) cannot measure the reinstatement of temporal response features; iii) are correlational in nature. To address these limitations and provide critical data on sensory reinstatement in human neocortex we will use intracranial recording and stimulation to study the precise anatomical (Aim 1), temporal (Aim 2) and causal (Aim 3) properties of visual reinstatement. Human electrocorticography (ECoG) provides the needed spatial and temporal precision for capturing and perturbing neural population activity at spatio-temporal scales undetectable with non-invasive methods. In Aim 1, we will use high-density ECoG recordings to quantify the spatial precision of reinstatement dynamics in higher order visual cortices, and quantify how stimulus selectivity relates to stimulus reinstatement. In Aim 2, we will test the temporal precision of reinstatement dynamics by inducing and manipulating oscillatory activities in primary visual cortex to test the fidelity of their reinstatement during retrieval. In Aim 3, we will use targeted electrical brain stimulation to test the causal role of sensory reinstatement in neocortex. Together, the Aims of this proposal will direct needed empirical attention towards the neural properties of neocortical reinstatement and causally test its role in human episodic memory retrieval. These advances will help elucidate how reinstatement like processes are exacerbated for conditions involving the intrusion of vivid mental content like post-traumatic stress disorder and schizophrenia.

情景记忆包括有意识地记住过去的事件，通常具有令人印象深刻的知觉程度