Posterior cingulate cortex and executive control of episodic memory

后扣带皮层和情景记忆的执行控制

• 批准号: 10661683
• 负责人: Brett Foster
• 金额: $ 68.89万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661683
• 关键词: Alzheimer' s Disease; Anatomy; Animal Model; Area; Behavior; Behavioral; Brain; Cerebral cortex; Cognitive; Complex; Consensus; Data; Disease; Dissociation; Dorsal; Electric Stimulation; Electrophysiology (science); Elements; Episodic memory; Event; Evoked Potentials; Failure; Fostering; Frequencies; Functional disorder; Goals; Hippocampus; Homologous Gene; Human; Human Characteristics; Infrastructure; Literature; Location; Maps; Measures; Medial; Memory; Memory impairment; Mental Depression; Metabolism; Modeling; Monkeys; Nerve Degeneration; Neurodegenerative Disorders; Neurons; Patients; Perception; Play; Population; Process; Regulation; Research; Retrieval; Rodent; Role; Schizophrenia; Signal Transduction; Site; System; Temporal Lobe; Testing; behavior test; cingulate cortex; cognitive function; common symptom; design; executive function; experience; experimental study; human model; insight; learned behavior; member; memory encoding; memory process; memory retrieval; multisensory; neural; neuroimaging; neurosurgery; news; nonhuman primate; novel; response

Project Summary Episodic memory involves the encoding and retrieval of past experiences to support learned behavior. Aside from these mnemonic processes, it also requires the ability to regulate memory (i.e. executive processes). For example, many real-world decisions will engage episodic retrieval, for which executive processes must help to integrate and evaluate the quality of remembered information (mnemonic evidence) and guide behavior to either decision, action, or continued memory search. While the neural basis of episodic memory encoding and retrieval have been a major focus of research, far less is known about its executive aspects. Executive mnemonic functions likely involve an anatomical substrate that is (i) multisensory/associative, (ii) engaged by memory/executive processing, and (iii) strongly interconnected with both mnemonic regions in the medial temporal lobe (MTL) and executive prefrontal (PFC) regions. Prior non-human primate studies, as well as human electrophysiology and neuroimaging data, suggest that posterior cingulate cortex (PCC) fulfills these criteria. Our central hypothesis is that the PCC plays a critical and unique role in executive control of episodic memory retrieval. We further hypothesize that it comprises three subregions regions: dorsal PCC, ventral PCC and retrosplenial cortex (RSC). These subregions are proposed to play complementary roles, corresponding to retrieval regulation, retrieval integration, and scene perception and transformation, respectively. In this account, PCC is a convergence zone of memory and executive systems, whose specific functional organization accounts for prior discrepancies between studies and species. Here, we utilize human intracranial recordings, including single unit data and stimulation within PCC, to better resolve the functional organization of this region. We will therefore employ an array of cognitive experiments to delineate three PCC subregions supporting the encoding, retrieval and executive control of memory processing (Aim 1). In delineating these subregions, we will also seek to differentiate PCC responses from those occurring in memory (MTL) and executive (dlPFC & ACC) functional networks (Aim 2). Finally, based on these observations, we will demonstrate the causal role of PCC subregions on behavior and local/network activity (Aim 3). By studying PCC, a convergence zone of memory and executive systems, progress can be made in elucidating how the failure to successfully leverage past experiences in daily behavior can occur as a common symptom of both neurodegenerative disease (e.g. Alzheimer’s disease) and multiple psychiatric conditions (e.g. schizophrenia) implicating PCC dysfunction.

项目摘要 情节记忆涉及对过去经验的编码和检索，以支持习得的行为。搁置一边 在这些记忆过程中，它还需要调节记忆的能力(即执行过程)。为 例如，许多现实世界的决策都会涉及情节检索，为此执行过程必须帮助 整合和评估记忆信息(助记证据)的质量，并引导行为 要么决定，要么行动，要么继续记忆搜索。而情节记忆编码的神经基础和 检索一直是研究的一个主要焦点，但对其执行方面的了解要少得多。执行人员 助记功能可能涉及(I)多感觉/联想的解剖基础，(Ii) 记忆/执行加工，以及(Iii)与内侧的两个助记区强烈相连 颞叶(MTL)和执行前额叶(PFC)区域。以前的非人类灵长类动物研究，以及 人类电生理学和神经成像数据表明，后扣带回(PCC)满足这些要求 标准。我们的中心假设是，PCC在发作的执行控制中发挥着关键和独特的作用 记忆恢复。我们进一步假设它由三个亚区组成：背侧PCC、腹侧PCC 和脾后皮质(RSC)。建议这些次区域发挥互补作用，对应于 检索规则、检索整合、场景感知与转换。在这 账户，PCC是内存和执行系统的汇聚区，其特定的功能 组织解释了先前研究和物种之间的差异。在这里，我们利用人类的颅内 录音，包括PCC内的单个单元数据和刺激，以更好地解决职能组织 这一地区的。因此，我们将利用一系列认知实验来描绘三个PCC亚区 支持记忆处理的编码、检索和执行控制(目标1)。在描述这些方面 子区域，我们还将设法将PCC响应与发生在内存中的响应(MTL)和 执行(dlPFC和ACC)功能网络(目标2)。最后，基于这些观察，我们将 展示PCC次区域对行为和本地/网络活动的因果作用(目标3)。通过研究 PCC是记忆和执行系统的汇聚区，在阐明 未能在日常行为中成功地利用过去的经验可能会成为这两种情况的共同症状 神经退行性疾病(如阿尔茨海默病)和多种精神疾病(如精神分裂症) 牵涉到PCC功能障碍。