Understanding Cardiovascular Disease Mechanisms

摘要 这是博士后和博士后培训计划的首次续签申请，其标题和主题是 《了解心血管疾病的机制》。辛辛那提大学和儿童医院 拥有超过40年的著名遗产，之前NIH T32对心血管研究的支持， 而目前的T32代表着辛辛那提唯一的简历计划。我们在这次续签中总共有18名教员 在他们的职业生涯中，将238名过去的实习生安排为学者，其中153人已经参选或目前 运行独立的研究计划。在过去的4年里，我们的17名学员发表了43篇论文 5名毕业生在支持期间获得了独立补助金，5名毕业生被录取到 科学职业生涯中的工作。我们培训计划的总体科学重点将继续建立在 心血管生理学、细胞生物学、生物化学和药理学的基础平台，还将 结合生物医学研究的最新方法，以及结合临床和翻译 接近了。辛辛那提儿童医院和辛辛那提大学的心血管环境是 被认为是这个国家最好的之一。我们的18名TG教职员工都是由NIH资助的(约47名NIH资助 其中包括PI状态)，165篇共同发表的合作论文，他们正在采用 拥有卓越核心支持的最新技术和方法。领导层由共同-- PiS Evangelia Kranias博士和Jeffery Molkentin博士，他们两人都有长期的合作记录 (20年)，以及优秀的导师资历。执行委员会(2名成员)， 内部咨询委员会(4名成员)和外部咨询委员会(3名成员)高度参与 心血管研究人员将继续帮助确保培训计划的质量。更新 要求继续为3个博士后和3个博士后实习生职位提供经费。前科医生是由 内部咨询委员会，来自7名系毕业生中的一大批杰出的候选人 计划，而博士后候选人是根据被导师的实验室录取和 然后通过内部咨询委员会和共同投资促进机构的筛选程序。指导计划 该计划的评估过程是高度结构化的，监督发生在多个层面上。实习生 导师每6个月进行一次评估，以处理国内流离失所者。拟议的教育培训 课程是高度结构化和最先进的。过去，招募少数族裔的做法一直很成功 与我们的教职员工合作，这仍将是首要任务。

ABSTRACT This is a first renewal application for a pre- and postdoctoral training program, the title and theme of which is “Understanding Cardiovascular Disease Mechanisms”. The University of Cincinnati and Children’s Hospital has a renowned legacy spanning more than 4 decades of previous NIH T32 support for cardiovascular study, and this current T32 represents the only CV program in Cincinnati. Our collective 18 faculty in this renewal have placed 238 of their past trainees into academics over their careers, 153 of whom have run, or currently run independent research programs. In the past 4 years of this program, our 17 trainees published 43 papers and 5 received independent grant funding during their support period, while 5 graduates have matriculated to jobs in scientific careers. The overall scientific emphasis of our training program will continue to build from a basic platform of cardiovascular physiology, cell biology, biochemistry and pharmacology, but will also incorporate the latest approaches in biomedical research, as well as incorporating clinical and translational approaches. The cardiovascular environment at Cincinnati Children’s and the University of Cincinnati is considered one of the very best in the country. Our 18 TG faculty are all NIH funded (some 47 NIH funding components amongst them as PI status), 165 collaborative papers published together, and they are employing the very latest technologies and approaches with outstanding core support. The leadership consists of the co- PIs Drs. Evangelia Kranias and Jeffery Molkentin, both of whom have a long track record of working together (20 years), as well as having excellent mentorship credentials. The Executive Committee (2 members), Internal Advisory Committee (4 members) and External Advisory Committee (3 members) are highly engaged cardiovascular researchers who will continue to help ensure the quality of the training program. The renewal requests continuation of the funding of 3 pre- and 3 postdoctoral trainee positions. Predocs are selected by the Internal Advisory Committee from a vast and outstanding pool of candidates amongst 7 departmental graduate programs, while postdoctoral candidates are selected based on being accepted into a mentor’s laboratory and then passing the screening process by the Internal Advisory Committee and co-PIs. The mentoring program and evaluation process for the program are highly structured and oversight occurs on many levels. Trainees and mentors are evaluated every 6 months with IDPs processing. The proposed educational training curriculum is highly structured and state-of-the-art. Recruitment of minorities has been successful in the past with our faculty, and it will remain a top priority.