Understanding Cardiovascular Disease Mechanisms

摘要 这是一个博士前和博士后培训计划的第一次更新申请，其标题和主题是 了解心血管疾病的机制。辛辛那提大学和儿童医院 拥有超过40年的NIH T32支持心血管研究的著名遗产， 而这个当前的T32代表了辛辛那提唯一的CV程序。我们的18名教师在这次更新中 在他们的职业生涯中，他们已经将238名过去的学员安置在学术界，其中153人已经或目前正在跑步， 开展独立的研究项目。在过去的4年里，我们的17名学员发表了43篇论文 5名毕业生在其支持期间获得了独立的赠款资助，而5名毕业生已被录取， 科学职业中的工作。我们的培训计划的整体科学重点将继续建立从一个 心血管生理学，细胞生物学，生物化学和药理学的基础平台，但也将 结合生物医学研究的最新方法，以及结合临床和转化 接近。辛辛那提儿童医院和辛辛那提大学的心血管环境 被认为是全国最好的医院之一我们的18个TG教师都是NIH资助的（约47个NIH资助 组成部分，其中作为PI状态），165合作论文一起发表，他们正在使用 最新的技术和方法，具有出色的核心支持。领导层由共同体组成， 私家侦探Evangelia Kranias博士和Jeffery Molkentin博士，他们两人都有长期的合作记录 (20年），以及具有良好的指导证书。执行委员会（2名成员）， 内部咨询委员会（4名成员）和外部咨询委员会（3名成员）高度参与 心血管研究人员将继续帮助确保培训计划的质量。更新 要求继续资助3个博士前和3个博士后实习生职位。Predocs由 内部咨询委员会从一个庞大的和优秀的人才库中的7个部门的毕业生 项目，而博士后候选人是根据被接受进入导师的实验室， 然后通过内部咨询委员会和共同PI的筛选过程。指导计划 该方案的评估程序是高度结构化的，监督发生在许多层面。学员 每6个月对辅导员进行一次评估，处理境内流离失所者问题。拟议的教育培训 课程结构高度合理，是最先进的。过去，少数民族的招聘是成功的 我们的教职员工，这将仍然是一个首要任务。

ABSTRACT This is a first renewal application for a pre- and postdoctoral training program, the title and theme of which is “Understanding Cardiovascular Disease Mechanisms”. The University of Cincinnati and Children’s Hospital has a renowned legacy spanning more than 4 decades of previous NIH T32 support for cardiovascular study, and this current T32 represents the only CV program in Cincinnati. Our collective 18 faculty in this renewal have placed 238 of their past trainees into academics over their careers, 153 of whom have run, or currently run independent research programs. In the past 4 years of this program, our 17 trainees published 43 papers and 5 received independent grant funding during their support period, while 5 graduates have matriculated to jobs in scientific careers. The overall scientific emphasis of our training program will continue to build from a basic platform of cardiovascular physiology, cell biology, biochemistry and pharmacology, but will also incorporate the latest approaches in biomedical research, as well as incorporating clinical and translational approaches. The cardiovascular environment at Cincinnati Children’s and the University of Cincinnati is considered one of the very best in the country. Our 18 TG faculty are all NIH funded (some 47 NIH funding components amongst them as PI status), 165 collaborative papers published together, and they are employing the very latest technologies and approaches with outstanding core support. The leadership consists of the co- PIs Drs. Evangelia Kranias and Jeffery Molkentin, both of whom have a long track record of working together (20 years), as well as having excellent mentorship credentials. The Executive Committee (2 members), Internal Advisory Committee (4 members) and External Advisory Committee (3 members) are highly engaged cardiovascular researchers who will continue to help ensure the quality of the training program. The renewal requests continuation of the funding of 3 pre- and 3 postdoctoral trainee positions. Predocs are selected by the Internal Advisory Committee from a vast and outstanding pool of candidates amongst 7 departmental graduate programs, while postdoctoral candidates are selected based on being accepted into a mentor’s laboratory and then passing the screening process by the Internal Advisory Committee and co-PIs. The mentoring program and evaluation process for the program are highly structured and oversight occurs on many levels. Trainees and mentors are evaluated every 6 months with IDPs processing. The proposed educational training curriculum is highly structured and state-of-the-art. Recruitment of minorities has been successful in the past with our faculty, and it will remain a top priority.