Understanding Cardiovascular Disease Mechanisms

 描述（由申请人提供）：这是一个新的申请前和博士后培训计划，其标题和主题是“了解心血管疾病机制”。虽然这是一个新的T32应用程序，心血管训练计划在辛辛那提大学和儿童医院有一个著名的遗产，由于35年前的NIH T32的支持下，博士阿诺德施瓦茨（最近没有更新）。这里提出的新领导层，连同一个更集中和高度资助的教师希望继续在心血管研究和指导的另一个35年在辛辛那提这一令人自豪的传统。我们的集体19教师已经放置了297他们过去的学员到学者在他们的职业生涯中，其中154人已经运行，或目前运行独立的研究项目。我们培训计划的整体科学重点将继续建立在心血管生理学，细胞生物学，生物化学和药理学的基础平台上，但也将纳入后基因组时代的最新方法，以及纳入临床和转化方法。辛辛那提儿童医院和辛辛那提大学的心血管环境被认为是全国最好的环境之一，拥有19名NIH资助的教师（其中约49名NIH赠款为PI状态），10年内发表了166篇合作论文，以及最新的技术和方法。领导层由共同PI Evangelia Kranias博士和Jeffery D. Molkentin，两人都有长期密切合作的记录（15年），以及优秀的导师资格证书。执行委员会（2名成员），内部咨询委员会（4名成员）和外部咨询委员会（3名成员）是高度参与的心血管研究人员，他们将有助于确保培训计划的质量。 目前的提案要求为3名博士前和3名博士后受训人员提供资金。Predocs是由内部咨询委员会从部门研究生课程中选出的，而博士后候选人则是根据被导师的实验室接受，然后通过内部咨询委员会和合作PI的筛选过程而选择的。该计划的指导计划和评估过程是高度结构化的，监督发生在许多层面上。学员和导师每6个月进行一次评估。拟议的教育培训课程是高度结构化和国家的最先进的。招聘少数民族也已成功地在过去与我们的教师，它将继续 是最优先的

 DESCRIPTION (provided by applicant): This is a new application for a pre- and postdoctoral training program, the title and theme of which is "Understanding Cardiovascular Disease Mechanisms". While this is a new T32 application, the cardiovascular training program at the University of Cincinnati and Children's Hospital has a renowned legacy due to 35 years of previous NIH T32 support under Dr. Arnold Schwartz (recently not renewed). The new leadership proposed here, together with a more focused and highly funded faculty wish to carry on this proud tradition of excellence in cardiovascular research and mentorship for another 35 years in Cincinnati. Our collective 19 faculty has placed 297 of their past trainees into academics over their careers, 154 of whom have run, or currently run independent research programs. The overall scientific emphasis of our training program will continue to build from a basic platform of cardiovascular physiology, cell biology, biochemistry and pharmacology, but will also incorporate the latest approaches in the post genomic era, as well as incorporating clinical and translational approaches. The cardiovascular environment at Cincinnati Children's and the University of Cincinnati is considered one of the very best in the country, with 19 NIH funded faculty (some 49 NIH grants amongst them as PI status), 166 collaborative papers published in 10 years, and the very latest technologies and approaches with outstanding core support. The leadership consists of the co-PIs Drs. Evangelia Kranias and Jeffery D. Molkentin, both of whom have a long standing track record of working closely together (15 years), as well as having excellent mentorship credentials. The Executive Committee (2 members), Internal Advisory Committee (4 members) and External Advisory Committee (3 members) are highly engaged cardiovascular researchers who will help ensure the quality of the training program. The current proposal requests funding for 3 pre- and 3 postdoctoral trainees. Predocs are selected by the Internal Advisory Committee from a wide pool arising from departmental graduate programs, while postdoctoral candidates are selected based on being accepted into a mentor's laboratory and then passing the screening process by the Internal Advisory Committee and co-PIs. The mentoring program and evaluation process for the program are highly structured and oversight occurs on many levels. Trainees and mentors are evaluated every 6 months. The proposed educational training curriculum is highly structured and state-of-the-art. Recruitment of minorities has also been successful in the past with our faculty, and it will remain a top priority.