Understanding Cardiovascular Disease Mechanisms

 描述(申请人提供)：这是一个新的博士后和博士后培训项目的申请，标题和主题是“了解心血管疾病的机制”。虽然这是一项新的T32应用程序，但辛辛那提大学和儿童医院的心血管培训计划由于在Arnold Schwartz博士(最近未续签)的领导下为NIH T32提供了35年的支持而拥有著名的遗产。这里提议的新领导层，以及更专注、资金更充裕的教职员工希望在辛辛那提再延续这一令人自豪的心血管研究和指导传统35年。我们共有19名教员，他们过去的受训人员中有297人在他们的职业生涯中进入了学术界，其中154人已经或目前正在运行独立研究项目。我们培训计划的总体科学重点将继续建立在心血管生理学、细胞生物学、生物化学和药理学的基础平台上，但也将纳入后基因组时代的最新方法，以及临床和翻译方法。辛辛那提儿童医院和辛辛那提大学的心血管环境被认为是全国最好的之一，拥有19名由NIH资助的教职员工(其中约49名NIH资助教师为PI)，在10年内发表了166篇合作论文，以及具有出色核心支持的最新技术和方法。领导层由共同的私人投资总监Evangelia Kranias博士和Jeffery D.Molkentin博士组成，他们两人都有长期密切合作的记录(15年)，并拥有出色的导师资历。执行委员会(2名成员)、内部咨询委员会(4名成员)和外部咨询委员会(3名成员)都是高度参与的心血管研究人员，他们将帮助确保培训计划的质量。目前的提案要求为3名博士后和3名博士后实习生提供资金。博士后由内部咨询委员会从院系研究生课程的大量人才库中挑选出来，而博士后候选人是根据被导师实验室录取，然后通过内部咨询委员会和联合绩效指标的筛选过程来挑选的。该计划的指导计划和评估过程是高度结构化的，并在许多层面上进行监督。学员和导师每6个月进行一次评估。拟议的教育培训课程是高度结构化和最先进的。过去，我们的教职员工也成功地招聘了少数族裔，这种情况将继续存在 这是重中之重。

 DESCRIPTION (provided by applicant): This is a new application for a pre- and postdoctoral training program, the title and theme of which is "Understanding Cardiovascular Disease Mechanisms". While this is a new T32 application, the cardiovascular training program at the University of Cincinnati and Children's Hospital has a renowned legacy due to 35 years of previous NIH T32 support under Dr. Arnold Schwartz (recently not renewed). The new leadership proposed here, together with a more focused and highly funded faculty wish to carry on this proud tradition of excellence in cardiovascular research and mentorship for another 35 years in Cincinnati. Our collective 19 faculty has placed 297 of their past trainees into academics over their careers, 154 of whom have run, or currently run independent research programs. The overall scientific emphasis of our training program will continue to build from a basic platform of cardiovascular physiology, cell biology, biochemistry and pharmacology, but will also incorporate the latest approaches in the post genomic era, as well as incorporating clinical and translational approaches. The cardiovascular environment at Cincinnati Children's and the University of Cincinnati is considered one of the very best in the country, with 19 NIH funded faculty (some 49 NIH grants amongst them as PI status), 166 collaborative papers published in 10 years, and the very latest technologies and approaches with outstanding core support. The leadership consists of the co-PIs Drs. Evangelia Kranias and Jeffery D. Molkentin, both of whom have a long standing track record of working closely together (15 years), as well as having excellent mentorship credentials. The Executive Committee (2 members), Internal Advisory Committee (4 members) and External Advisory Committee (3 members) are highly engaged cardiovascular researchers who will help ensure the quality of the training program. The current proposal requests funding for 3 pre- and 3 postdoctoral trainees. Predocs are selected by the Internal Advisory Committee from a wide pool arising from departmental graduate programs, while postdoctoral candidates are selected based on being accepted into a mentor's laboratory and then passing the screening process by the Internal Advisory Committee and co-PIs. The mentoring program and evaluation process for the program are highly structured and oversight occurs on many levels. Trainees and mentors are evaluated every 6 months. The proposed educational training curriculum is highly structured and state-of-the-art. Recruitment of minorities has also been successful in the past with our faculty, and it will remain a top priority.