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Development of Ultrasound Imaging Phantoms Appropriate for Quantification of Muscle Fascicle Architecture and Mechanical Properties

开发适合量化肌肉束结构和机械性能的超声成像模型

基本信息

批准号：
10427254
负责人：
Wendy M Murray
金额：
--
依托单位：
EDWARD HINES JR VA HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10427254
关键词：
3D Print Ablation Achievement Address Adopted Adoption Adult Age Aging Anatomy Architecture Area Biopsy Blood Vessels Chronic Obstructive Pulmonary Disease Clinic Clinical Clinical Research Crosslinker Data Analyses Dependence Development Device or Instrument Development Diagnosis Disease Exercise Extracellular Matrix Fascicle Fiber Formulation Funding Future Generations Goals Gold Human Hydrogels Image Imaging Phantoms Individual Injury Intervention Liquid substance Measurement Measures Mechanics Medical Imaging Methods Modality Morphology Muscle Muscle Development Muscle function Musculoskeletal Diseases Musculoskeletal System Nerve Organ Performance Persons Phase Physicians Physiological Play Prevalence Procedures Production Property Protocols documentation PubMed Reporting Research Research Methodology Research Personnel Review Literature Role Sampling Scientist Shapes Skeletal Muscle Standardization Stress Stretching Stroke Structure System Techniques Tendinopathy Testing Testosterone Time Tissues Training Translations Ultrasonography Validation Veterans Work arm clinical implementation clinical practice cost crosslink design disease disparity elastography experience healing human subject imaging modality improved in vivo in vivo imaging interest mechanical properties muscular structure musculoskeletal ultrasound new technology novel photocuring pre-clinical research preclinical study prototype systematic review tumor two-dimensional ultrasound

项目摘要

Because of its low cost and ease of use, there is widespread adoption of ultrasound as an imaging modality for the musculoskeletal system. For example, traditional, two-dimensional, brightness mode (B-mode) ultrasound is currently being implemented to quantify muscle morphological adaptations in vivo for a broad and disparate range of applications. Ultrasound elastography, a newer modality, is increasingly being applied to the quantification of human muscle tissue mechanical properties. Clinically, musculoskeletal ultrasound has been promoted as a “first-line imaging modality” for 72 clinical indications. Despite the increasing prevalence of musculoskeletal ultrasound, there remain critical limitations for its implementation and for interpretation of the data that results. Clinically, reliability and standardization of training are considered significant obstacles limiting the quality of clinical ultrasound assessments. Similarly, there is a critical, unmet need to improve validation methods for the research application of ultrasound imaging. For example, a systematic review of the literature describing the implementation of B-mode ultrasound for measurement of muscle morphometric parameters concludes that, while the evidence supports its validity, the evidence is extremely limited and there are substantial caveats on this conclusion. There are similar limitations relevant to the study of muscle mechanical properties via ultrasound imaging. We propose the development of muscle-like phantoms as a first step toward addressing common issues of reliability, validation, and standardization of training for ultrasound imaging, that connect research and the clinic. In medical imaging, phantoms are mockups of the tissue of interest, synthesized to mimic critical features, known geometric organization, or relevant material composition; they are commonly implemented to establish a type of “gold-standard” performance measure. There are no commercially available phantoms that are applicable to establish how accurately and reliably either muscle structure or mechanical properties can be quantified via ultrasound. As a result, the true utility of these widely adopted imaging methods is not being achieved. This application describes a preclinical study, focused on prototype device development. The long-term goal for this work is to develop a range of muscle-like phantoms that will enable the study of different muscle architectures and include physiologically relevant material properties. In this two-year SPiRE funding period, we will (1) develop materials that mimic the mechanical properties of human muscle and are suitable for ultrasound imaging, and (2) use these materials to 3D print muscle-like phantoms. We will evaluate the phantoms we produce relative to how well they replicate structural and material properties of muscles commonly assessed with ultrasound imaging. The first aim of this study is to develop printable hydrogels that mimic the passive and active mechanical properties of muscle. The deliverables of this aim include: (i) quantification of the range of Young’s moduli achievable via 3D printing of hydrogels using a novel third generation stereolithography method, (ii) demonstration that these materials are suitable for shear wave imaging, (iii) characterization of the maximum stresses the resulting materials can sustain, and (iv) identification of the formulations that best replicate the desired properties of skeletal muscle. The second aim will create phantoms that enable the study of muscle architecture and mechanics with ultrasound. Using the range of materials developed in Aim 1, we will print artificial muscles that replicate the range of sizes, shapes, and mechanical properties present in the adult human arm. Phantoms will be evaluated on the ability to distinguish individual fascicles using B-mode ultrasound imaging, to sustain loads comparable to human muscle, and to have load-dependent material properties spanning the range reported for muscle. Ultimately, the work proposed here will characterize the potential with which 3D printing can address the need for muscle-like imaging phantoms, setting the stage for both a future Merit Review in this area and an assessment of the viability of such a product for commercial translation.

由于其成本低且易于使用，超声作为一种成像方式被广泛采用肌肉骨骼系统。例如，传统的二维亮度模式（B 模式）超声波是目前正在实施以量化体内肌肉形态适应，以适应广泛且不同的情况应用范围。超声弹性成像作为一种较新的模式，越来越多地应用于人体肌肉组织机械特性的量化。临床上，肌肉骨骼超声检查被推广为适用于 72 种临床适应症的“一线成像方式”。尽管越来越流行肌肉骨骼超声，其实施和解释仍然存在严重的局限性结果的数据。临床上，训练的可靠性和标准化被认为是限制训练的重大障碍。临床超声评估的质量。同样，改进验证也存在一个关键的、未满足的需求超声成像研究应用方法。例如，对文献进行系统回顾描述 B 型超声测量肌肉形态参数的实施得出的结论是，虽然证据支持其有效性，但证据极其有限，并且存在对这一结论的重大警告。肌肉力学的研究也存在类似的局限性通过超声成像的特性。我们建议开发类似肌肉的模型作为解决常见问题的第一步超声成像培训的可靠性、验证性和标准化，将研究与实际联系起来诊所。在医学成像中，体模是感兴趣组织的模型，经过合成以模仿关键特征，已知的几何组织或相关的材料成分；它们通常是为了建立一个 “黄金标准”绩效衡量标准的类型。没有适用的市售模型确定如何准确可靠地量化肌肉结构或机械特性超声波。结果，这些广泛采用的成像方法的真正效用尚未实现。该申请描述了一项临床前研究，重点关注原型设备开发。长期来看这项工作的目标是开发一系列类似肌肉的模型，以便研究不同的肌肉架构并包括生理相关的材料特性。在这两年的 SPiRE 资助期内，我们将 (1) 开发模仿人体肌肉机械特性并适用于超声波的材料成像，(2) 使用这些材料 3D 打印类似肌肉的模型。我们将评估我们的幻影产生的效果与它们复制通常评估的肌肉的结构和材料特性的程度有关与超声成像。这项研究的第一个目标是开发可打印的水凝胶，模仿被动和肌肉的主动机械特性。这一目标的可交付成果包括： (i) 量化范围使用新型第三代立体光刻方法通过水凝胶 3D 打印可实现杨氏模量， (ii) 证明这些材料适合剪切波成像，(iii) 最大所产生的材料可以承受的压力，以及（iv）确定最能复制的配方骨骼肌的所需特性。第二个目标是创造能够研究肌肉的模型超声波的建筑和力学。使用目标 1 中开发的一系列材料，我们将打印复制成年人的尺寸、形状和机械特性的人造肌肉手臂。将评估体模使用 B 型超声区分各个神经束的能力成像，以承受与人体肌肉相当的负载，并具有负载相关的材料特性跨越了报告的肌肉范围。最终，这里提出的工作将描述潜力 3D打印可以满足类肌肉成像模型的需求，为未来奠定基础该领域的优点审查以及此类产品用于商业翻译的可行性评估。