Lake Erie Center for the Great Lakes and Human Health

伊利湖五大湖与人类健康中心

• 批准号: 10427310
• 负责人: George S Bullerjahn
• 金额: $ 30.39万
• 依托单位: BOWLING GREEN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10427310
• 关键词: Address; Area; Attention; Boat; Chronic; Coast Guard; Collaborations; Communities; Complement; Core Facility; Data; Detection; Development; Environment; Environmental Health; Environmental Science; Event; Faculty; Forestry; Fostering; Fresh Water; Funding Opportunities; Goals; Grant; Habitats; Health; Human; Human Resources; Institution; Interdisciplinary Study; International; Investments; Journals; Laboratory Research; Lead; Leadership; Michigan; Monitor; National Oceanic and Atmospheric Administration; North Carolina; Nutrient; Oceans; Ohio; Policies; Productivity; Publications; Recording of previous events; Research; Research Activity; Research Project Grants; Risk; Role; Science; Services; Shapes; Solid; Structure; System; Tennessee; Toxic effect; Toxin; Universities; Vision; Water; Water Supply; Work; anthropogenesis; biomedical scientist; citizen science; climate change; climate impact; college; community engaged research; community engagement; drinking water; foodborne; harmful algal blooms; improved; innovation; inter-institutional; lipidomics; medical schools; metabolomics; metatranscriptomics; multidisciplinary; operation; programs; research facility; response; symposium; technology development; tool; water quality

OVERALL: SUMMARY The Lake Erie Center for Fresh Waters and Human Health at Bowling Green State University (BGSU) seeks five years of support from the Centers for Oceans and Human Health 3: Impacts of Climate Change on Oceans and Great Lakes program (COHH3) (P01). Support is requested for research, facilities operations and community engagement activities that build on academic and agency partnerships that have developed in the wake of the 2014 Toledo Water Crisis. Locating this COHH3 at BGSU reflects a leading role assumed by BGSU personnel studying the chronic cyanobacterial Harmful Algal Blooms (cHABs) of Lake Erie and complements significant ongoing investments made by BGSU. A COHH3 Lake Erie Center for Fresh Waters and Human Health will promote inter-institution collaboration to generate cutting-edge research toward identifying environmental drivers of cHABs and the effect of climate change on the proliferation and toxicity of bloom events and their impact on human health. This Center will shape the national research agenda; promote community engagement; and leverage strong institutional and agency support. Presently aligned as a multi-disciplinary research area in Lake Erie and Watershed Studies at BGSU, this effort seeks to formalize relations with affiliates active in cHAB research elsewhere. BGSU personnel were pressed into action to help lead the scientific response to the 2014 Toledo Water Crisis following contamination of Toledo's water supply by cHAB toxins. With the crisis still unfolding, BGSU coordinated with Center affiliates to study the bloom event and communicate issues related to the crisis to a concerned public. With the water crisis still receiving national attention, BGSU assumed the lead in organizing an international symposium held at BGSU in April 2015 which provided a forum to share ideas related to cHABs and their mitigation. BGSU also worked closely with federal legislators in the aftermath of the crisis to address issues of water quality in Lake Erie leading to the passing of H.R. 212, The Drinking Water Protection Act. The proposed research activities of Center affiliates are consistent with the goals and structure outlined for COHH3 with projects addressing human health effects of cHABs in the framework of climate change, toxin discovery and toxicity, enhanced monitoring/forecasting and community engagement. This application pursues four overarching goals: 1) Create an integrated, multi-disciplinary Center facilitating collaboration between biomedical scientists and limnologists; 2) Heighten the scientific influence, innovation, and productivity of Center affiliates; 3) Support development of Center affiliates including junior faculty; and 4) Energize cHAB science with new data and research tools. These goals will be accomplished through integration of projects and by supporting four complementary cores: Administrative, Research, Community Engagement, and Facilities. Center affiliates are providing national leadership, and our vision is to continue to foster an environment of innovation and collaboration that yields high impact research on cutting-edge issues related to climate change and its effect on cHABs and their impact on human health.

总体：总结 鲍林格林州立大学 (BGSU) 伊利湖淡水与人类健康中心寻求五名 海洋与人类健康中心多年的支持 3：气候变化对海洋和人类健康的影响 五大湖计划 (COHH3) (P01)。请求对研究、设施运营和社区提供支持 以学术和机构伙伴关系为基础的参与活动，这些伙伴关系是在 2014 年托莱多水危机。该 COHH3 位于 BGSU 体现了 BGSU 人员所承担的领导作用 研究伊利湖的慢性蓝藻有害藻华 (chHAB) 并补充重要的信息 BGSU 正在进行的投资。 COHH3 伊利湖淡水和人类健康中心将 促进机构间合作，开展尖端研究，以确定环境驱动因素 cHAB 的影响以及气候变化对水华事件扩散和毒性的影响及其对 人类健康。该中心将制定国家研究议程；促进社区参与；和 利用强有力的机构和机构支持。目前已成为湖区的一个多学科研究领域 伊利和 BGSU 的流域研究，这项工作旨在与活跃于 cHAB 的附属机构建立正式关系 在其他地方进行研究。 BGSU 人员被迫采取行动，帮助领导对 2014 年的科学反应 托莱多供水系统受到 cHAB 毒素污染后，引发托莱多水危机。危机依然存在 随着开花事件的展开，BGSU 与中心附属机构协调研究开花事件并就相关问题进行沟通 对相关公众的危机。水危机仍备受全国关注，北水北调率先行动 2015 年 4 月在 BGSU 组织了一次国际研讨会，为分享想法提供了论坛 与 cHAB 及其缓解措施相关。 BGSU 还与联邦立法者在事件发生后密切合作。 解决伊利湖水质问题的危机导致 H.R. 212《饮用水》的通过 保护法。中心附属机构拟议的研究活动与目标和结构一致 为 COHH3 概述了在气候变化框架内解决 cHAB 对人类健康影响的项目， 毒素发现和毒性、加强监测/预测和社区参与。这个应用程序 追求四个总体目标： 1) 创建一个综合的、多学科的中心，促进合作 生物医学科学家和湖沼学家之间； 2）提高科学影响力、创新力和生产力 中心附属机构； 3）支持中心附属机构（包括初级教师）的发展； 4) 为 cHAB 注入能量 科学与新数据和研究工具。这些目标将通过项目的整合来实现 通过支持四个互补的核心：行政、研究、社区参与和设施。 中心附属机构正在提供国家领导力，我们的愿景是继续营造一个 创新与合作，对气候变化相关的前沿问题进行高影响力的研究 及其对 cHAB 的影响及其对人类健康的影响。

项目成果

Insight Into the Molecular Mechanisms for Microcystin Biodegradation in Lake Erie and Lake Taihu

• DOI: 10.3389/fmicb.2019.02741
• 发表时间: 2019-12-10
• 期刊: FRONTIERS IN MICROBIOLOGY
• 影响因子: 5.2
• 作者: Krausfeldt, Lauren E.;Steffen, Morgan M.;Wilhelm, Steven W.
• 通讯作者: Wilhelm, Steven W.

Metagenome-Assembled Genome of a Pseudanabaena sp. from a Crimson Cyanobacterial Bloom in Lake Salubria, New York, USA.

• DOI: 10.1128/mra.00494-22
• 发表时间: 2022-09-15
• 期刊: MICROBIOLOGY RESOURCE ANNOUNCEMENTS
• 影响因子: 0.8
• 作者: Martin, Robbie M.;Gann, Eric R.;Truchon, Alex R.;Boyer, Gregory L.;Wilhelm, Steven W.
• 通讯作者: Wilhelm, Steven W.

The “Neglected Viruses” of Taihu: Abundant Transcripts for Viruses Infecting Eukaryotes and Their Potential Role in Phytoplankton Succession

• DOI: 10.3389/fmicb.2020.00338
• 发表时间: 2020-03
• 期刊: Frontiers in Microbiology
• 影响因子: 5.2
• 作者: H. Pound;Eric R. Gann;Xiangming Tang;Lauren E. Krausfeldt;M. Huff;M. Staton;D. Talmy;S. Wilhelm

Interactions between chytrids cause variable infection strategies on harmful algal bloom forming species

壶菌之间的相互作用导致有害藻华形成物种的不同感染策略

• DOI: 10.1016/j.hal.2023.102381
• 发表时间: 2023
• 期刊: Harmful Algae
• 影响因子: 6.6
• 作者: McKindles, Katelyn M.;McKay, R. Michael;Bullerjahn, George S.;Frenken, Thijs
• 通讯作者: Frenken, Thijs

Cool temperature acclimation in toxigenic Microcystis aeruginosa PCC 7806 and its non-toxigenic mutant.

产毒铜绿微囊藻 PCC 7806 及其非产毒突变体的低温驯化。

• DOI: 10.1101/2023.08.28.555099
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Stark,GwendolynF;Martin,RobbieM;Smith,LauraE;Wei,Bofan;Hellweger,FerdiL;Bullerjahn,GeorgeS;McKay,RMichaelL;Boyer,GregoryL;Wilhelm,StevenW
• 通讯作者: Wilhelm,StevenW