Training Grant on the Biology of Aging

衰老生物学培训补助金

• 批准号: 10427178
• 负责人: PETER J HORNSBY
• 金额: $ 42.46万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10427178
• 关键词: Biology of Aging; Grant; Training

SUMMARY For the past three decades, the University of Texas Health Science Center at San Antonio (UTHSCSA) has hosted a premier Training Program in the biology of aging that has resulted in the development of a new generation of leaders in this field. This application seeks to continue this T32 Training Program and we request funds to support four predoctoral and four postdoctoral trainees. In this funding period, we are building on our unparalleled record of success and expand the program to prepare trainees in the emerging area of Geroscience, term that encompasses (1) fundamentals of basic aging biology; (2) the relationship between aging biology and the etiology of age-related disease; and (3) principles of translational research in biological aging. Our overarching objective is to catalyze development of interventions that modulate the aging process, leading to an extension of healthspan. The achievement of this goal requires a cadre of dedicated young researchers who have received multi-disciplinary training. Thus, this T32 Training Program aims to attract outstanding young scientists and train them in a vibrant and collaborative environment rich in Geroscience resources. The Training Program involves 48 faculty members and takes advantage of the synergies created by their intense collaborations across 7 departments. Our Geroscience training environment is second to none, and features the Barshop Institute, a Nathan Shock Center, our new Claude D. Pepper Center, a Geriatric Research, Education and Clinical Center, and the Interventions Testing Program. Since 1988, this T32 has trained many outstanding researchers in Geroscience, including current members of the current T32 Faculty. Our former trainees have been awarded numerous federal grants (including F, K and R series awards), and include Assistant or Associate Professors. Drs. Nicolas Musi, Peter Hornsby and Veronica Galvan will co-direct this Program and are supported by an Internal Steering Committee and an External Advisory Committee. The Faculty expertise crosses the spectrum of aging biology (inflammation, senescence, metabolism, epigenetics, macromolecular damage, proteostasis, stem cells); genesis of age-related diseases (cancer, diabetes, Alzheimer's disease, osteoporosis, sarcopenia); and early-phase translational research. The principal components of the Training Program are: (1) participation with graded responsibility in the laboratory of an experienced investigator; (2) commitment to collaboration and the use of multidisciplinary research approaches; (3) continuing research-in-progress seminars; (4) integrated lecture/journal club series on Geroscience; (5) courses and seminars in the responsible conduct of research, scientific communication, grantsmanship and peer review; (6) a rigorous group mentoring design; (7) preparation of an individual development plan and comprehensive evaluation of trainee progress; (8) continued evaluation and teaching of mentoring skills for faculty preceptors; and (9) active recruitment of meritorious trainees and faculty preceptors to reflect workforce ethnic/racial diversity. Trainee access to on-going departmental conferences, clinical rounds and courses further enhances the training experience.

概括 在过去的三十年里，德克萨斯大学圣安东尼奥健康科学中心 (UTHSCSA) 主持了一项关于衰老生物学的重要培训计划，该计划开发了一种新的 该领域的一代领袖。此申请旨在继续此 T32 培训计划，我们要求 资金支持四名博士前培训生和四名博士后培训生。在本次资助期间，我们正在加强我们的 无与伦比的成功记录并扩大了该计划，为老年科学新兴领域的学员做好准备， 术语包含 (1) 基本衰老生物学的基础知识； （2）衰老生物学与衰老的关系 与年龄相关的疾病的病因学； (3)生物衰老转化研究的原则。我们的 总体目标是促进调节衰老过程的干预措施的发展，从而实现 延长健康寿命。实现这一目标需要一支敬业的年轻研究人员队伍 接受过多学科培训。因此，本次T32培训计划旨在吸引优秀的年轻人 科学家并在充满活力、协作且富含老年科学资源的环境中对他们进行培训。培训 该计划涉及 48 名教职人员，并充分利用了他们紧张的工作所产生的协同效应 7个部门的合作。我们的老年科学培训环境是首屈一指的，并具有 巴肖普研究所 (Barshop Institute)、内森休克中心 (Nathan Shock Center)、我们新的克劳德 D. 佩珀中心 (Claude D. Pepper Center)、老年研究、教育中心 和临床中心，以及干预测试计划。自1988年以来，这台T32培养了许多优秀的人才 老年科学领域的研究人员，包括现任 T32 学院的现任成员。我们以前的练习生有 曾获得多项联邦拨款（包括 F、K 和 R 系列奖项），并包括助理或助理 教授们。博士。 Nicolas Musi、Peter Hornsby 和 Veronica Galvan 将共同指导该计划并获得支持 由内部指导委员会和外部咨询委员会组成。学院的专业知识跨越 衰老生物学谱（炎症、衰老、新陈代谢、表观遗传学、大分子损伤、 蛋白质稳态、干细胞）；与年龄相关的疾病（癌症、糖尿病、阿尔茨海默病、骨质疏松症、 肌肉减少症）；和早期转化研究。培训计划的主要组成部分是：（1） 参与由经验丰富的研究者负责的实验室； (2) 承诺 协作和多学科研究方法的使用； (3) 继续进行中的研究 研讨会； (4) 老年科学综合讲座/期刊俱乐部系列； (5) 负责人的课程和研讨会 进行研究、科学交流、资助和同行评审； （六）严格的小组辅导 设计; （七）制定个人发展计划并对学员进步进行综合评价； (8) 继续评估和教授教师导师的指导技能； (9) 积极招募 优秀的学员和教师导师，以反映劳动力的民族/种族多样性。学员可以访问正在进行的 部门会议、临床查房和课程进一步增强了培训体验。