TRAINING GRANT ON THE BIOLOGY OF AGING

衰老生物学培训补助金

• 批准号: 7618331
• 负责人: STEVEN N. AUSTAD
• 金额: $ 34.35万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2008-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7618331
• 关键词: Biology of Aging; Grant; Training

This application is a new training program for research scientists in the areas of genetics of aging, lifespan intervention analyses in animal models, and age-related diseases. Pre- and post-doctoral fellows (10 and 6 per year respectively) will be trained in the biology of aging. The trainees will participate in projects involving: programmed changes in gene expression; somatic mutations and epigenetic changes in gene expression; free radicals, DNA damage and DNA repair; aging of endocrine and immune systems; transmembrane signaling; oncogenes and tumor suppressor genes in cell growth, differentiation and apoptosis; and the molecular aspects of age-associated diseases such as Alzheimer's disease, Parkinson's disease and prostatic hyperplasia and neoplasia. The Biology of Aging course and journal clubs on current topics in gerontology will provide the formal setting for didactic training. The Aging Seminar Series will be the focal point of interactions of the trainees with eminent scientists working in the field of aging. Trainees will be selected based on their interest in aging, academic excellence, and motivation for careers in research, instruction and service as reflected from their academic records, and letters of recommendations. The Institutional core facilities for generating transgenic mice, biometry, recombinant DNA technology, hybridoma, flow cytometry microassay and confocal microscopy will be available to all trainees and the participating faculty.This program is comprised of 27 faculty trainers of whom 22 are funded by the NIA. Two are newly recruited Assistant Professors with a clear interest in aging. The three senior investigators with other funding are interested in aging, involved in teaching in the Aging course, and participating in the journal club, and provide research interests that add to, rather than duplicate, that of the other trainers. As a result, the trainees will have a broad range of research to choose from and they will work with individuals who have demonstrated their training ability. San Antonio has the unique situation of having access to and recruiting minorities from the undergraduate universities in the area, e.g., University of Texas at San Antonio and St. Mary's University. A strong effort will be made to do just this. Support of this program has all the potential of training a much needed group of scientists; the gerontologists of the future.

这个应用程序是一个新的培训计划的研究科学家在该地区的遗传学的老化，寿命 动物模型的干预分析，以及与年龄相关的疾病。博士前和博士后研究员（10名和6名 将接受衰老生物学方面的培训。学员将参加项目 涉及：基因表达的程序性变化;基因的体细胞突变和表观遗传变化 表达;自由基，DNA损伤和DNA修复;内分泌和免疫系统老化; 跨膜信号传导;癌基因和肿瘤抑制基因在细胞生长，分化和 细胞凋亡;以及年龄相关疾病的分子方面，如阿尔茨海默病，帕金森病， 疾病和前列腺增生和肿瘤。衰老的生物学课程和期刊俱乐部对当前 老年学专题将为教学培训提供正式背景。老龄化研讨会系列将是 学员与老龄领域杰出科学家互动的焦点。学员 将根据他们对老龄化的兴趣，学术成就和职业动机进行选择， 研究，教学和服务，反映在他们的学术记录，和推荐信。 该机构的核心设施，用于产生转基因小鼠，生物统计学，重组DNA技术， 杂交瘤、流式细胞术微量分析和共聚焦显微镜将向所有受训者提供， 该方案由27名教员培训员组成，其中22人由NIA资助。两 是新招聘的助理教授，对衰老有明显的兴趣。三名高级调查员与 其他资金对老龄化感兴趣，参与老龄化课程的教学，并参与期刊 俱乐部，并提供研究兴趣，增加，而不是重复，其他教练。因此，在本发明中， 学员将有广泛的研究选择，他们将与个人谁拥有 展示了他们的训练能力。圣安东尼奥有一个独特的情况， 该地区本科大学的少数民族，例如，得克萨斯大学圣安东尼奥和圣。 玛丽的大学。将为此作出巨大努力。对该计划的支持具有以下所有潜力： 培养一批急需的科学家;未来的老年病学家。