TRAINING GRANT ON THE BIOLOGY OF AGING

描述（由申请人提供）：拟议的项目是一项为期5年的老龄化生物学机构培训补助金，该补助金于2003年从两个部门培训补助金中合并而来。申请资助10名博士预科生和6名博士后。美国即将出现的老年人雪崩，加上最近在了解老龄化基本机制方面取得的重大进展，对受过培训的研究人员产生了巨大的需求，这些研究人员需要研究延缓和缓解老龄化人口疾病的方法。位于圣安东尼奥的德克萨斯大学健康科学中心是衰老生物学领域的一流研究机构，目前从美国国家衰老研究所（NIA）的衰老生物学项目获得的研究经费比其他任何独立医疗机构都多。提出的培训计划的主要目标是为研究生和博士后在衰老基础生物学研究领域的领导者做好智力准备。该培训项目涉及25名教职员工（14名男性，11名女性），并充分利用由紧密合作的员工创造的协同效应，利用我们的内森·肖克卓越衰老生物学中心提供的独特资源，以及对巴肖普研究所本身的机构承诺和不断扩大的资源。学员将根据他们的学术成就、对老龄化研究的兴趣和对研究事业的动机进行竞争。每个受训者的主要活动是发展他们的教师监督的研究项目，由于我们的教师之间的合作程度往往会产生令人惊讶的团队指导。另一个关键的组成部分是要求在我们的两门衰老生物学课程中获得广泛的衰老生物学知识，以便学员能够将他们的研究置于适当的科学背景中。除了这种正式的教学培训，我们还要求学员参加每周的老龄化研究杂志俱乐部和Barshop研究所系列研讨会。我们的项目还强调科学交流的培训，通过多个场所让学员磨练书面和口头表达的技能。拟议的培训计划的时机是有利的，因为它将跨越我们的研究生项目的过渡，从目前的状态作为细胞与结构生物学系的一个特殊的衰老生物学轨道，到它未来的状态作为一个独立的研究生项目——全国第一个衰老生物学博士项目。这一过渡进程已经开始，并将在拟议的筹资期间完成。

DESCRIPTION (provided by applicant): The proposed program represents a 5-year continuation of an institutional training grant in the biology of aging, which was consolidated in 2003 from two departmental training grants. We request funds to support 10 predoctoral and 6 postdoctoral trainees. The impending avalanche of elderly in the US combined with major recent advances in understanding fundamental mechanisms of aging has created a substantial demand for researchers trained to investigate means of delaying and relieving the ailments of an aging population. The University of Texas Health Science Center at San Antonio is a premier research institution in the biology of aging, currently receiving more research funding from the Biology of Aging Program of the National Institute on Aging (NIA) than any other stand-alone medical institution. The primary goal of the proposed Training Program is to intellectually prepare both graduate students and postdoctoral fellows for careers as leaders in basic biological research in aging. The Training Program involves 25 faculty members (14 men, 11 women) and takes advantage of the synergies created by intensely collaborative personnel, the unique resources available from our Nathan Shock Center of Excellence in the Biology of Aging and the institutional commitment to, and expanding resources of, the Barshop Institute itself. Trainees will be chosen competitively based on academic excellence, their interest in aging research, and motivation for careers in research. The main activity of each trainee is the development of their faculty-supervised research project, which because of the extent of collaboration among our faculty tends to result surprisingly often in team mentorships. Another key component is to require broad knowledge in the biology of aging acquired in our two biology of aging courses such that trainees can place their research in an appropriate scientific context. In addition to this formal didactic training, we require trainees to attend the weekly Aging Research Journal Club and the Barshop Institute seminar series. Our program also emphasizes training in scientific communication with multiple venues for trainees to hone skills in both written and oral presentation. The timing of the proposed Training Program is propitious in that it will span the transition of our graduate student program from its current status as a Special Biology of Aging Track within the Department of Cellular & Structural Biology to its future status as an independent graduate program - the nation's first Ph.D. program in the Biology of Aging. That transition process has already been initiated and will be completed during the proposed funding period. This application is a new training program for research scientists in the areas of genetics of aging, lifespan intervention analyses in animal models, and age-related diseases. Pre- and post-doctoral fellows (10 and 6 per year respectively) will be trained in the biology of aging. The trainees will participate in projects involving: programmed changes in gene expression; somatic mutations and epigenetic changes in gene expression; free radicals, DNA damage and DNA repair; aging of endocrine and immune systems; transmembrane signaling; oncogenes and tumor suppressor genes in cell growth, differentiation and apoptosis; and the molecular aspects of age-associated diseases such as Alzheimer's disease, Parkinson's disease and prostatic hyperplasia and neoplasia. The Biology of Aging course and journal clubs on current topics in gerontology will provide the formal setting for didactic training. The Aging Seminar Series will be the focal point of interactions of the trainees with eminent scientists working in the field of aging. Trainees will be selected based on their interest in aging, academic excellence, and motivation for careers in research, instruction and service as reflected from their academic records, and letters of recommendations. The Institutional core facilities for generating transgenic mice, biometry, recombinant DNA technology, hybridoma, flow cytometry microassay and confocal microscopy will be available to all trainees and the participating faculty. This program is comprised of 27 faculty trainers of whom 22 are funded by the NIA. Two are newly recruited Assistant Professors with a clear interest in aging. The three senior investigators with other funding are interested in aging, involved in teaching in the Aging course, and participating in the journal club, and provide research interests that add to, rather than duplicate, that of the other trainers. As a result, the trainees will have a broad range of research to choose from and they will work with individuals who have demonstrated their training ability. San Antonio has the unique situation of having access to and recruiting minorities from the undergraduate universities in the area, e.g., University of Texas at San Antonio and St. Mary's University. A strong effort will be made to do just this. Support of this program has all the potential of training a much needed group of scientists; the gerontologists of the future.