Training Grant on the Biology of Aging

衰老生物学培训补助金

• 批准号: 10640877
• 负责人: PETER J HORNSBY
• 金额: $ 12.28万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10640877
• 关键词: Biology of Aging; Grant; Training

SUMMARY For the past three decades, the University of Texas Health Science Center at San Antonio (UTHSCSA) has hosted a premier Training Program in the biology of aging that has resulted in the development of a new generation of leaders in this field. This application seeks to continue this T32 Training Program and we request funds to support four predoctoral and four postdoctoral trainees. In this funding period, we are building on our unparalleled record of success and expand the program to prepare trainees in the emerging area of Geroscience, term that encompasses (1) fundamentals of basic aging biology; (2) the relationship between aging biology and the etiology of age-related disease; and (3) principles of translational research in biological aging. Our overarching objective is to catalyze development of interventions that modulate the aging process, leading to an extension of healthspan. The achievement of this goal requires a cadre of dedicated young researchers who have received multi-disciplinary training. Thus, this T32 Training Program aims to attract outstanding young scientists and train them in a vibrant and collaborative environment rich in Geroscience resources. The Training Program involves 48 faculty members and takes advantage of the synergies created by their intense collaborations across 7 departments. Our Geroscience training environment is second to none, and features the Barshop Institute, a Nathan Shock Center, our new Claude D. Pepper Center, a Geriatric Research, Education and Clinical Center, and the Interventions Testing Program. Since 1988, this T32 has trained many outstanding researchers in Geroscience, including current members of the current T32 Faculty. Our former trainees have been awarded numerous federal grants (including F, K and R series awards), and include Assistant or Associate Professors. Drs. Nicolas Musi, Peter Hornsby and Veronica Galvan will co-direct this Program and are supported by an Internal Steering Committee and an External Advisory Committee. The Faculty expertise crosses the spectrum of aging biology (inflammation, senescence, metabolism, epigenetics, macromolecular damage, proteostasis, stem cells); genesis of age-related diseases (cancer, diabetes, Alzheimer's disease, osteoporosis, sarcopenia); and early-phase translational research. The principal components of the Training Program are: (1) participation with graded responsibility in the laboratory of an experienced investigator; (2) commitment to collaboration and the use of multidisciplinary research approaches; (3) continuing research-in-progress seminars; (4) integrated lecture/journal club series on Geroscience; (5) courses and seminars in the responsible conduct of research, scientific communication, grantsmanship and peer review; (6) a rigorous group mentoring design; (7) preparation of an individual development plan and comprehensive evaluation of trainee progress; (8) continued evaluation and teaching of mentoring skills for faculty preceptors; and (9) active recruitment of meritorious trainees and faculty preceptors to reflect workforce ethnic/racial diversity. Trainee access to on-going departmental conferences, clinical rounds and courses further enhances the training experience.

摘要 在过去的三十年里，位于圣安东尼奥的德克萨斯大学健康科学中心(UTHSCSA) 主持了一项关于衰老生物学的主要培训计划，该计划导致了一种新的 这一领域的新一代领导者。此申请旨在继续此T32培训计划，我们请求 资助四名博士后和四名博士后实习生的资金。在这一资金阶段，我们将在我们的基础上 无与伦比的成功记录，并扩大该计划，为新兴的老年科学领域的实习生做准备， 包括(1)衰老生物学的基本原理；(2)衰老生物学与 年龄相关疾病的病因学；(3)生物衰老的翻译研究原则。我们的 总体目标是促进干预措施的发展，以调节衰老过程，导致 延长健康寿命。实现这一目标需要一支敬业的年轻研究人员队伍，他们 都接受过多学科的培训。因此，这项T32培训计划旨在吸引优秀的年轻人 并在充满活力和协作的环境中培训他们，这些环境拥有丰富的老年科学资源。培训 该计划涉及48名教职员工，并利用其密集的 跨7个部门的协作。我们的老年科学培训环境是首屈一指的，具有 Barshop研究所，内森休克中心，我们新的克劳德·D·佩珀中心，老年研究，教育 和临床中心，以及干预测试计划。自1988年以来，这位T32培养了许多优秀的 老年科学的研究人员，包括目前T32学院的现任成员。我们以前的实习生 获得过多项联邦奖助金(包括F、K和R系列奖项)，包括助理或助理 教授们。尼古拉斯·穆西博士、彼得·霍恩斯比博士和维罗妮卡·加尔文博士将共同指导这个项目，并得到支持 由一个内部指导委员会和一个外部咨询委员会负责。学院的专业知识跨越了 衰老生物学(炎症、衰老、新陈代谢、表观遗传学、大分子损伤、 蛋白质平衡、干细胞)；与年龄有关的疾病(癌症、糖尿病、阿尔茨海默病、骨质疏松症、 石棺减少)；以及早期阶段的翻译研究。培训计划的主要组成部分是：(1) 有经验的调查员以分级责任参与实验室；(2)致力于 协作和使用多学科研究方法；(3)持续进行中的研究 研讨会；(4)老年科学综合讲座/期刊俱乐部系列；(5)负责人的课程和研讨会 进行研究、科学交流、赠款和同行审查；(6)严格的小组指导 设计；(7)编制个人发展计划和综合评价受训人员的进展情况；(8) 继续评价和教授教员的指导技能；以及(9)积极征聘 功勋实习生和教员教官，以反映劳动力、族裔/种族的多样性。实习生可以访问正在进行的 科室会议、临床查房和课程进一步提升了培训体验。

项目成果

PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts.

• DOI: 10.1038/cdd.2009.150
• 发表时间: 2010-04
• 期刊: CELL DEATH AND DIFFERENTIATION
• 影响因子: 12.4
• 作者: Matheny, R. W., Jr.;Adamo, M. L.
• 通讯作者: Adamo, M. L.

Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease.

• DOI: 10.1371/journal.pone.0031522
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Wey MC;Fernandez E;Martinez PA;Sullivan P;Goldstein DS;Strong R
• 通讯作者: Strong R

ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair.

• DOI: 10.1371/journal.pone.0091222
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Brown AD;Sager BW;Gorthi A;Tonapi SS;Brown EJ;Bishop AJ
• 通讯作者: Bishop AJ

Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels.

• DOI: 10.1016/j.bbrc.2012.05.055
• 发表时间: 2012-06-08
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Lustgarten MS;Bhattacharya A;Muller FL;Jang YC;Shimizu T;Shirasawa T;Richardson A;Van Remmen H
• 通讯作者: Van Remmen H

14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis.

• DOI: 10.1371/journal.pone.0015864
• 发表时间: 2011-01-10
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Ravi D;Chen Y;Karia B;Brown A;Gu TT;Li J;Carey MS;Hennessy BT;Bishop AJ
• 通讯作者: Bishop AJ