Training Grant on the Biology of Aging

衰老生物学培训补助金

• 批准号: 10640877
• 负责人: PETER J HORNSBY
• 金额: $ 12.28万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10640877
• 关键词: Biology of Aging; Grant; Training

SUMMARY For the past three decades, the University of Texas Health Science Center at San Antonio (UTHSCSA) has hosted a premier Training Program in the biology of aging that has resulted in the development of a new generation of leaders in this field. This application seeks to continue this T32 Training Program and we request funds to support four predoctoral and four postdoctoral trainees. In this funding period, we are building on our unparalleled record of success and expand the program to prepare trainees in the emerging area of Geroscience, term that encompasses (1) fundamentals of basic aging biology; (2) the relationship between aging biology and the etiology of age-related disease; and (3) principles of translational research in biological aging. Our overarching objective is to catalyze development of interventions that modulate the aging process, leading to an extension of healthspan. The achievement of this goal requires a cadre of dedicated young researchers who have received multi-disciplinary training. Thus, this T32 Training Program aims to attract outstanding young scientists and train them in a vibrant and collaborative environment rich in Geroscience resources. The Training Program involves 48 faculty members and takes advantage of the synergies created by their intense collaborations across 7 departments. Our Geroscience training environment is second to none, and features the Barshop Institute, a Nathan Shock Center, our new Claude D. Pepper Center, a Geriatric Research, Education and Clinical Center, and the Interventions Testing Program. Since 1988, this T32 has trained many outstanding researchers in Geroscience, including current members of the current T32 Faculty. Our former trainees have been awarded numerous federal grants (including F, K and R series awards), and include Assistant or Associate Professors. Drs. Nicolas Musi, Peter Hornsby and Veronica Galvan will co-direct this Program and are supported by an Internal Steering Committee and an External Advisory Committee. The Faculty expertise crosses the spectrum of aging biology (inflammation, senescence, metabolism, epigenetics, macromolecular damage, proteostasis, stem cells); genesis of age-related diseases (cancer, diabetes, Alzheimer's disease, osteoporosis, sarcopenia); and early-phase translational research. The principal components of the Training Program are: (1) participation with graded responsibility in the laboratory of an experienced investigator; (2) commitment to collaboration and the use of multidisciplinary research approaches; (3) continuing research-in-progress seminars; (4) integrated lecture/journal club series on Geroscience; (5) courses and seminars in the responsible conduct of research, scientific communication, grantsmanship and peer review; (6) a rigorous group mentoring design; (7) preparation of an individual development plan and comprehensive evaluation of trainee progress; (8) continued evaluation and teaching of mentoring skills for faculty preceptors; and (9) active recruitment of meritorious trainees and faculty preceptors to reflect workforce ethnic/racial diversity. Trainee access to on-going departmental conferences, clinical rounds and courses further enhances the training experience.

总结 在过去的三十年里，德克萨斯大学圣安东尼奥健康科学中心（UTHSCSA） 主办了一个首屈一指的培训计划，在生物学的老化，导致了一个新的发展， 这一领域的领导者。本申请旨在继续T32培训计划，我们要求 资助四名博士前和四名博士后学员。在这段融资期内，我们将在 无与伦比的成功记录，并扩大该计划，以准备在新兴领域的老年科学的学员， 一个术语，包括（1）基本老化生物学的基础;（2）老化生物学与 年龄相关疾病的病因学;（3）生物衰老转化研究的原则。我们 总体目标是促进调节衰老过程的干预措施的发展， 延长健康寿命。要实现这一目标，需要一批具有献身精神的年轻研究人员， 接受过多学科的培训。因此，T32培训计划旨在吸引优秀的年轻人， 科学家和培训他们在一个充满活力和协作的环境中丰富的老年科学资源。培训 该计划涉及48名教职员工，并利用他们强烈的协同作用， 7个部门的合作。我们的老年科学培训环境是首屈一指的， 巴肖普研究所，内森休克中心，我们的新克劳德D。佩珀中心，老年医学研究，教育 和临床中心，以及干预测试计划。自1988年以来，这辆T32已经培养了许多优秀的 研究人员在老年科学，包括目前的T32教师的现任成员。我们以前的学员 获得了许多联邦资助（包括F，K和R系列奖项），并包括助理或助理 教授们。Nicolas Musi博士、Peter Hornsby博士和Veronica Galvan博士将共同指导该项目，并得到支持。 一个内部指导委员会和一个外部咨询委员会。学院的专业知识跨越 衰老生物学谱（炎症、衰老、代谢、表观遗传学、大分子损伤， 蛋白质稳态，干细胞）;年龄相关疾病（癌症，糖尿病，阿尔茨海默病，骨质疏松症， 肌肉减少症）;和早期转化研究。培训方案的主要组成部分是：（1） 由经验丰富的研究者参与实验室工作并承担分级责任;（2）承诺 合作和多学科研究方法的使用;（3）持续的研究进展 研讨会;（4）关于老年科学的综合讲座/期刊俱乐部系列;（5）负责人的课程和研讨会 开展研究、科学交流、专家评审和同行评审;（6）严格的小组指导 设计;（7）制定个人发展计划并对受训者的进展进行全面评估;（8） 继续评估和教授教师导师的指导技能;以及（9）积极招聘 优秀的学员和教师导师，以反映劳动力的民族/种族多样性。学员可持续利用 部门会议，临床查房和课程进一步加强了培训经验。

项目成果

PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts.

• DOI: 10.1038/cdd.2009.150
• 发表时间: 2010-04
• 期刊: CELL DEATH AND DIFFERENTIATION
• 影响因子: 12.4
• 作者: Matheny, R. W., Jr.;Adamo, M. L.
• 通讯作者: Adamo, M. L.

Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease.

• DOI: 10.1371/journal.pone.0031522
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Wey MC;Fernandez E;Martinez PA;Sullivan P;Goldstein DS;Strong R
• 通讯作者: Strong R

ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair.

• DOI: 10.1371/journal.pone.0091222
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Brown AD;Sager BW;Gorthi A;Tonapi SS;Brown EJ;Bishop AJ
• 通讯作者: Bishop AJ

Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels.

• DOI: 10.1016/j.bbrc.2012.05.055
• 发表时间: 2012-06-08
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Lustgarten MS;Bhattacharya A;Muller FL;Jang YC;Shimizu T;Shirasawa T;Richardson A;Van Remmen H
• 通讯作者: Van Remmen H

14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis.

• DOI: 10.1371/journal.pone.0015864
• 发表时间: 2011-01-10
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Ravi D;Chen Y;Karia B;Brown A;Gu TT;Li J;Carey MS;Hennessy BT;Bishop AJ
• 通讯作者: Bishop AJ