TRAINING GRANT ON THE BIOLOGY OF AGING

衰老生物学培训补助金

• 批准号: 7175625
• 负责人: OLIVIA M. PEREIRA-SMITH
• 金额: $ 1.79万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7175625
• 关键词: TRAINING; GRANT; BIOLOGY; AGING

DESCRIPTION (provided by applicant): This application is a new training program for research scientists in the areas of genetics of aging, lifespan intervention analyses in animal models, and age-related diseases. Pre- and post-doctoral fellows (10 and 6 per year respectively) will be trained in the biology of aging. The trainees will participate in projects involving: programmed changes in gene expression; somatic mutations and epigenetic changes in gene expression; free radicals, DNA damage and DNA repair; aging of endocrine and immune systems; transmembrane signaling; oncogenes and tumor suppressor genes in cell growth, differentiation and apoptosis; and the molecular aspects of age-associated diseases such as Alzheimer's disease, Parkinson's disease and prostatic hyperplasia and neoplasia. The Biology of Aging course and journal clubs on current topics in gerontology will provide the formal setting for didactic training. The Aging Seminar Series will be the focal point of interactions of the trainees with eminent scientists working in the field of aging. Trainees will be selected based on their interest in aging, academic excellence, and motivation for careers in research, instruction and service as reflected from their academic records, and letters of recommendations. The Institutional core facilities for generating transgenic mice, biometry, recombinant DNA technology, hybridoma, flow cytometry microassay and confocal microscopy will be available to all trainees and the participating faculty. This program is comprised of 27 faculty trainers of whom 22 are funded by the NIA. Two are newly recruited Assistant Professors with a clear interest in aging. The three senior investigators with other funding are interested in aging, involved in teaching in the Aging course, and participating in the journal club, and provide research interests that add to, rather than duplicate, that of the other trainers. As a result, the trainees will have a broad range of research to choose from and they will work with individuals who have demonstrated their training ability. San Antonio has the unique situation of having access to and recruiting minorities from the undergraduate universities in the area, e.g., University of Texas at San Antonio and St. Mary's University. A strong effort will be made to do just this. Support of this program has all the potential of training a much needed group of scientists; the gerontologists of the future.

描述（由申请人提供）：该应用程序是一个新的培训计划，为研究科学家在衰老遗传学，动物模型中的寿命干预分析和年龄相关疾病领域。博士前和博士后研究员（每年分别为10名和6名）将接受衰老生物学方面的培训。 受训人员将参加的项目涉及：基因表达的程序性变化;基因表达的体细胞突变和表观遗传变化;自由基、DNA损伤和DNA修复;内分泌和免疫系统的老化;跨膜信号;细胞生长、分化和凋亡中的癌基因和抑癌基因;以及与年龄相关的疾病如阿尔茨海默病、帕金森病和前列腺增生和肿瘤的分子方面。老龄生物学课程和期刊俱乐部在老年学当前的主题将提供正式的教学培训设置。老龄化研讨会系列将是学员与老龄化领域杰出科学家互动的焦点。学员将根据他们对老龄化的兴趣，学术卓越，以及从他们的学术记录和推荐信中反映的研究，教学和服务职业的动机来选择。用于产生转基因小鼠、生物统计学、重组DNA技术、杂交瘤、流式细胞术微量测定和共聚焦显微镜的机构核心设施将提供给所有学员和参与教师。该计划由27名教员培训师组成，其中22名由NIA资助。两个是新招聘的助理教授，对衰老有明显的兴趣。三名有其他资金的高级研究人员对衰老感兴趣，参与衰老课程的教学，并参加期刊俱乐部，并提供增加而不是重复其他培训师的研究兴趣。因此，受训人员将有广泛的研究可供选择，他们将与那些表现出培训能力的人一起工作。圣安东尼奥有一个独特的情况，即可以从该地区的本科大学获得并招募少数民族，例如，德克萨斯大学圣安东尼奥分校和圣玛丽大学。我们将付出巨大的努力来做到这一点。对这一计划的支持有可能培养出一批急需的科学家，即未来的老年病学家。