San Antonio Nathan Shock Center of Excellence in the Biology of Aging

凭借其不断发展的核心，丰富和培训计划，并支持研究项目，圣安东尼奥 (SA)内森休克中心已为约25年提供关键支持，调查当地，全国和 国外凭借其现有的和不断增长的智力资本，SA休克中心准备提供（1） 加强平台，进行横向整合（寿命、健康寿命、病理学、药理学） 衰老生物学的变革性研究，以及（2）高级教育和培训的跳板 活动南森休克中心的具体目标是： 1.成为研究的领导者，促进我们对衰老生物学的理解 2.提供"一站式"场所，加速衰老生物学的变革性研究 3.培养和促进衰老生物学早期研究人员的职业发展 4.作为其他休克中心、机构和公众调查人员的资源和合作伙伴， 传播科学知识，提高对老龄研究的认识 为达致这些目标，我们已善用及精简资源和优势， 相互关联的核心：1）行政和计划充实核心; 2）研究开发（RD）核心; 3） 衰老动物模型和长寿评估核心; 4）衰老核心综合生理学（IPAC）; 5） 病理学核心;和6）分析药理学和药物评价核心。这些核心将提供一个 综合场地进行和促进仔细的表型和良好的综合（即寿命，健康寿命， 病理学）老化研究。利用这些核心，我们将应用遗传学、生物化学和药理学 本发明的方法用于几种脊椎动物模型，包括啮齿动物（小鼠、大鼠、鼹鼠）和绒猴。 基于我们过去的经验和成功，我们充分预期，我们增强的平台和培训 这些活动将极大地促进对影响衰老的分子和细胞机制的鉴定。这 这种方法将导致新的策略和（药理学）目标的识别，以延长健康的生活 期待 该SA休克中心是建立在一个独特的基础上提供UTHSCSA的特殊和紧密 综合资源：a Claude D.胡椒老年美国人独立中心（OAIC），一个网站的 干预测试计划（ITP），老年研究，教育和临床中心（GRECC），T32 老年科学培训补助金，以及一个强大的Barshop研究所，联合UTHSCSA的老龄化研究。我们 唯一的休克中心与所有这些协同组件可用。此外，SA休克中心 获得无与伦比的机构承诺（约500，000美元/年），包括新的约1亿美元109，000平方米。英尺 建筑-具体的巴肖普研究所-这将容纳休克中心，克劳德佩珀OAIC和 ITP位于中心位置。

With its evolving Cores, enrichment and training programs, and supported research projects, the San Antonio (SA) Nathan Shock Center has for ~25 years provided critical support to investigators locally, nationally and abroad. With its existing and growing intellectual capital, the SA Shock Center is poised to provide (1) an enhanced platform to conduct horizontally-integrated (lifespan, healthspan, pathology, pharmacology) transformative research in the biology of aging, and (2) a springboard for advanced educational and training activities. The Specific Aims of the SA Nathan Shock Center are: 1. To be a leader in research that advances our understanding of the biology of aging 2. To provide a `one-stop-shop' venue to accelerate transformative research in the biology of aging 3. To foster and promote career development of early-stage investigators in aging biology 4. To serve as a resource and partner to investigators from other Shock Centers, institutions, and the public, for dissemination of scientific knowledge and enhancing awareness about aging research To achieve these objectives we have leveraged and streamlined our resources and strengths to create six interrelated cores: 1) Administration and Program Enrichment Core; 2) Research Development (RD) Core; 3) Aging Animal Models and Longevity Assessment Core; 4) Integrative Physiology of Aging Core (IPAC); 5) Pathology Core; and 6) the Analytical Pharmacology and Drug Evaluation Core. These cores will provide an integrated venue to conduct and facilitate carefully phenotyped and well-integrated (i.e. lifespan, healthspan, pathology) aging studies. Using these cores, we will apply genetic, biochemical, and pharmacologic methodologies to several vertebrate animal models including rodents (mice, rats, mole-rats), and marmosets. Based on our past experiences and successes, we fully anticipate that our enhanced platform and training activities will greatly facilitate the identification of molecular and cellular mechanisms that influence aging. This approach will result in novel strategies and the identification of (pharmacologic) targets to extend healthy life expectancy. The SA Shock Center is built on a unique foundation provided by UTHSCSA's exceptional and tightly integrated resources: a Claude D. Pepper Older Americans Independence Center (OAIC), a site of the Interventions Testing Program (ITP), a Geriatric Research, Education and Clinical Center (GRECC), a T32 Training Grant on Geroscience, and a robust Barshop Institute that unites aging research at UTHSCSA. We are the only Shock Center with all of these synergistic components available. In addition, the SA Shock Center receives unparalleled institutional commitment (~$500,000/year), including a new ~$100M 109,000 sq. ft. building – specific for the Barshop Institute – that will house the Shock Center, the Claude Pepper OAIC and the ITP in a centrally located facility.