Seattle Tuberculosis Research Advancement Center

项目总结(总体) 西雅图结核病研究促进中心(SEA-TRAC)的愿景是促进 通过培训和多学科研究减少全球结核病负担。SEA-TRAC将 通过催生新的研究途径和培训一批新的调查人员来实现这一点，这将使 对全球流行病产生有意义的影响。SEA-TRAC将在西雅图的三个世界级机构运营： 华盛顿大学(UW)、西雅图儿童研究所和弗雷德·哈钦森癌症 研究中心。我们会利用与本地非学术机构的紧密伙伴关系，例如 系统生物学、西雅图金县公共卫生、PATH以及国际合作伙伴，如 肯尼亚医学研究所。行政核心将领导SEA-TRAC并承担以下责任 战略规划和业务管理以及促进一种环境，以促进将 带来新的协作和资金申请。SEA-TRAC的核心将是发展核心， 它将监督几个旨在促进职业发展的新的教育、培训和赠款计划 对结核病研究新手的初级或高级调查人员。临床和转化科学的核心意志 领导临床研究方法学方面的培训和咨询，并促进与我们的 国际合作伙伴。基础科学核心将为在生物安全领域工作的新科学家提供培训 3级(BSL3)环境以及高级微生物学和免疫学方面的领导培训和咨询 方法：研究方法。最后，数据科学核心将利用我们在生物统计、计算方面的本地优势 生物学和建模主办社区建设活动，如结核病黑客周，为科学家提供培训 他们是数据科学的新手，并为高级研究问题提供咨询服务。我们的领导层 团队由致力于培训和指导的教职员工组成，代表 科学兴趣的多样性、终身教职阶段、性别和我们研究界的种族。我们已经确保了 总计861,420美元的机构承诺，或总直接成本的29%，这将使我们能够支持多样化的 一旦获得资金，立即提供一整套计划。SEA-TRAC将建立在已经建立的坚实基础上 由威斯康星大学结核病研究与培训中心(TRTC)在过去五年中建立的核， 加强和扩大我们研究的影响。到供资期末，我们预计SEA-TRAC 将实现几个可量化的目标，并将自己确立为TRAC计划的旗舰项目，领导 通过与其他TRAC和NIH的互动实现新的倡议。

PROJECT SUMMARY (OVERALL) The Vision of the Seattle Tuberculosis (TB) Research Advancement Center (SEA-TRAC) is to facilitate a decrease in the global burden of TB through training and multi-disciplinary research. SEA-TRAC will accomplish this by catalyzing new avenues of research and training a cadre of new investigators that will make a meaningful impact on the global epidemic. SEA-TRAC will operate from three world class institutions in Seattle: The University of Washington (UW), Seattle Children’s Research Institute, and Fred Hutchinson Cancer Research Center. We will leverage close partnerships with local non-academic entities, such as the Institute for Systems Biology, Public Health Seattle King County, and PATH as well as international partners, such as the Kenya Medical Research Institute. The Administrative Core will lead SEA-TRAC and assume responsibility for strategic planning and operational management as well as promoting an environment to foster dialogue that will lead to new collaborations and funding applications. The heart of SEA-TRAC will be the Development Core, which will oversee several new educational, training, and grant programs designed to foster career development of junior or senior investigators that are new to TB research. The Clinical and Translational Science Core will lead training and consulting in clinical research methodology and foster collaborative research with our international partners. The Basic Science Core will provide training for scientists new to working in the Biosafety Level 3 (BSL3) environment and lead training and consulting in advanced microbiology and immunology methods. Finally, the Data Sciences Core will leverage our local strengths in Biostatistics, Computational Biology, and Modeling to host community building events, such as TB ‘hackweeks,’ provide training to scientists that are new to data science, and offer consulting services for advanced research questions. Our Leadership Team is composed of faculty with a demonstrated commitment to training and mentorship that represent the diversity of scientific interests, tenure stage, gender, and ethnicity of our research community. We have secured institutional commitments totaling $861,420 or 29% of total direct costs that will allow us to support a diverse suite of programs immediately upon funding. SEA-TRAC will build on the strong foundation that has been established over the last five years by the UW Tuberculosis Research & Training Center (TRTC) to nucleate, strengthen, and expand the impact of our research. By the end of the funding period, we expect that SEA-TRAC will have achieved several quantifiable objectives and established itself as a flagship TRAC program, leading new initiatives through interactions with other TRACs and the NIH.