Seattle Tuberculosis Research Advancement Center

项目概要（总体） 西雅图结核病（TB）研究促进中心（SEA-TRAC）的愿景是促进 通过培训和多学科研究减少全球结核病负担。SEA-TRAC将 通过催化新的研究途径和培训新的研究人员， 对全球疫情产生重大影响。SEA-TRAC将在西雅图的三个世界级机构运作： 华盛顿大学（UW）、西雅图儿童研究所和弗雷德哈钦森癌症 研究中心我们会与本地非学术机构，例如香港理工大学 系统生物学、公共卫生西雅图金郡和适宜卫生技术组织以及国际合作伙伴，如 肯尼亚医学研究所。行政核心将领导东南大西洋-TRAC，并负责 战略规划和业务管理，以及促进一种促进对话的环境， 导致新的合作和资金申请。SEA-TRAC的核心将是发展核心， 该委员会将监督几项旨在促进职业发展的新的教育、培训和资助项目 初级或高级研究人员对结核病研究的新认识。临床和转化科学核心将 领导临床研究方法的培训和咨询，并促进与我们的 国际伙伴。基础科学核心将为新从事生物安全工作的科学家提供培训， 3级（BSL 3）环境和领先的培训和咨询在先进的微生物学和免疫学 方法.最后，数据科学核心将利用我们在生物统计学、计算 生物学和建模举办社区建设活动，如结核病“黑客周”，为科学家提供培训 这是新的数据科学，并提供咨询服务，为先进的研究问题。我们的领导 团队由教师组成，他们对培训和指导的承诺代表了 科学兴趣的多样性，任期阶段，性别和我们的研究社区的种族。我们已经获得 机构承诺总额为861，420美元，占直接成本总额的29%，这将使我们能够支持多样化的 一套方案立即到位。SEA-TRAC将建立在已经建立的坚实基础上， 在过去的五年里，由华盛顿大学结核病研究与培训中心（TRTC）建立， 加强和扩大我们的研究的影响。到供资期结束时，我们预计SEA-TRAC 将实现几个可量化的目标，并确立自己作为TRAC旗舰方案的地位， 通过与其他TRAC和NIH的互动，制定新的举措。

PROJECT SUMMARY (OVERALL) The Vision of the Seattle Tuberculosis (TB) Research Advancement Center (SEA-TRAC) is to facilitate a decrease in the global burden of TB through training and multi-disciplinary research. SEA-TRAC will accomplish this by catalyzing new avenues of research and training a cadre of new investigators that will make a meaningful impact on the global epidemic. SEA-TRAC will operate from three world class institutions in Seattle: The University of Washington (UW), Seattle Children’s Research Institute, and Fred Hutchinson Cancer Research Center. We will leverage close partnerships with local non-academic entities, such as the Institute for Systems Biology, Public Health Seattle King County, and PATH as well as international partners, such as the Kenya Medical Research Institute. The Administrative Core will lead SEA-TRAC and assume responsibility for strategic planning and operational management as well as promoting an environment to foster dialogue that will lead to new collaborations and funding applications. The heart of SEA-TRAC will be the Development Core, which will oversee several new educational, training, and grant programs designed to foster career development of junior or senior investigators that are new to TB research. The Clinical and Translational Science Core will lead training and consulting in clinical research methodology and foster collaborative research with our international partners. The Basic Science Core will provide training for scientists new to working in the Biosafety Level 3 (BSL3) environment and lead training and consulting in advanced microbiology and immunology methods. Finally, the Data Sciences Core will leverage our local strengths in Biostatistics, Computational Biology, and Modeling to host community building events, such as TB ‘hackweeks,’ provide training to scientists that are new to data science, and offer consulting services for advanced research questions. Our Leadership Team is composed of faculty with a demonstrated commitment to training and mentorship that represent the diversity of scientific interests, tenure stage, gender, and ethnicity of our research community. We have secured institutional commitments totaling $861,420 or 29% of total direct costs that will allow us to support a diverse suite of programs immediately upon funding. SEA-TRAC will build on the strong foundation that has been established over the last five years by the UW Tuberculosis Research & Training Center (TRTC) to nucleate, strengthen, and expand the impact of our research. By the end of the funding period, we expect that SEA-TRAC will have achieved several quantifiable objectives and established itself as a flagship TRAC program, leading new initiatives through interactions with other TRACs and the NIH.