Seattle Tuberculosis Research Advancement Center

西雅图结核病研究促进中心

• 批准号: 10595064
• 负责人: Rhea N Coler
• 金额: $ 104.31万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-21 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10595064
• 关键词: Award; Basic Science; Biometry; Charge; Child; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Computational Biology; Consultations; County; Data Science; Data Science Core; Development; Direct Costs; Education; Ensure; Environment; Epidemic; Ethnic Origin; Event; Faculty; Fostering; Foundations; Fred Hutchinson Cancer Research Center; Funding; Future; Gender; Grant; Heart; Immune response; Immunology; Institution; Interdisciplinary Study; International; Kenya; Knowledge; Lead; Leadership; Medical Research; Mentorship; Methodology; Methods; Microbiology; Modeling; Mycobacterium tuberculosis; Public Health; Research; Research Institute; Research Methodology; Research Personnel; Science; Scientist; Secure; Services; Strategic Planning; Systems Biology; Training; Translational Research; Translations; Tuberculosis; United States National Institutes of Health; Universities; Vision; Washington; career development; clinical database; clinical epidemiology; cohort; community building; design; implementation science; interest; multidisciplinary; next generation; programs; recruit; skills

PROJECT SUMMARY (OVERALL) The Vision of the Seattle Tuberculosis (TB) Research Advancement Center (SEA-TRAC) is to facilitate a decrease in the global burden of TB through training and multi-disciplinary research. SEA-TRAC will accomplish this by catalyzing new avenues of research and training a cadre of new investigators that will make a meaningful impact on the global epidemic. SEA-TRAC will operate from three world class institutions in Seattle: The University of Washington (UW), Seattle Children’s Research Institute, and Fred Hutchinson Cancer Research Center. We will leverage close partnerships with local non-academic entities, such as the Institute for Systems Biology, Public Health Seattle King County, and PATH as well as international partners, such as the Kenya Medical Research Institute. The Administrative Core will lead SEA-TRAC and assume responsibility for strategic planning and operational management as well as promoting an environment to foster dialogue that will lead to new collaborations and funding applications. The heart of SEA-TRAC will be the Development Core, which will oversee several new educational, training, and grant programs designed to foster career development of junior or senior investigators that are new to TB research. The Clinical and Translational Science Core will lead training and consulting in clinical research methodology and foster collaborative research with our international partners. The Basic Science Core will provide training for scientists new to working in the Biosafety Level 3 (BSL3) environment and lead training and consulting in advanced microbiology and immunology methods. Finally, the Data Sciences Core will leverage our local strengths in Biostatistics, Computational Biology, and Modeling to host community building events, such as TB ‘hackweeks,’ provide training to scientists that are new to data science, and offer consulting services for advanced research questions. Our Leadership Team is composed of faculty with a demonstrated commitment to training and mentorship that represent the diversity of scientific interests, tenure stage, gender, and ethnicity of our research community. We have secured institutional commitments totaling $861,420 or 29% of total direct costs that will allow us to support a diverse suite of programs immediately upon funding. SEA-TRAC will build on the strong foundation that has been established over the last five years by the UW Tuberculosis Research & Training Center (TRTC) to nucleate, strengthen, and expand the impact of our research. By the end of the funding period, we expect that SEA-TRAC will have achieved several quantifiable objectives and established itself as a flagship TRAC program, leading new initiatives through interactions with other TRACs and the NIH.

项目概要（总体） 西雅图结核病 (TB) 研究进展中心 (SEA-TRAC) 的愿景是促进 通过培训和多学科研究减少全球结核病负担。 SEA-TRAC 将 通过促进新的研究途径和培训一批新的研究人员来实现这一目标 对全球疫情产生重大影响。 SEA-TRAC 将由西雅图的三个世界级机构运营： 华盛顿大学 (UW)、西雅图儿童研究所和 Fred Hutchinson 癌症中心 研究中心。我们将利用与当地非学术实体的密切合作关系，例如研究所 系统生物学、西雅图金县公共卫生和 PATH 以及国际合作伙伴，例如 肯尼亚医学研究所。行政核心将领导 SEA-TRAC 并负责 战略规划和运营管理，以及促进促进对话的环境， 带来新的合作和资金申请。 SEA-TRAC 的核心将是开发核心， 该机构将监督多项旨在促进职业发展的新教育、培训和资助计划 刚接触结核病研究的初级或高级研究人员。临床和转化科学核心将 领导临床研究方法的培训和咨询，并促进与我们的合作研究 国际合作伙伴。基础科学核心将为刚从事生物安全工作的科学家提供培训 3 级 (BSL3) 环境以及高级微生物学和免疫学方面的领先培训和咨询 方法。最后，数据科学核心将利用我们在生物统计学、计算方面的本地优势 生物学和建模举办社区建设活动，例如结核病“黑客周”，为科学家提供培训 这是数据科学领域的新手，并为高级研究问题提供咨询服务。我们的领导 团队由致力于培训和指导的教师组成，代表了 我们研究界的科学兴趣、任期阶段、性别和种族的多样性。我们已确保 机构承诺总计 861,420 美元，占直接成本总额的 29%，这将使我们能够支持多元化 资助后立即推出一系列计划。 SEA-TRAC 将建立在已经建立的坚实基础上 威斯康星大学结核病研究与培训中心 (TRTC) 在过去五年中建立了核心， 加强并扩大我们研究的影响。到资助期结束时，我们预计 SEA-TRAC 将实现几个可量化的目标，并将自己确立为旗舰 TRAC 计划，领先 通过与其他 TRAC 和 NIH 的互动采取新举措。