FASEB SRC on The Biology of Cilia and Flagella

摘要 纤毛和鞭毛是从细胞表面突出到细胞内的线状细胞器。 环境长期被忽视，纤毛生物学的研究已经看到了巨大的增长， 在过去的二十年中，它们在细胞传感和人类疾病中的核心作用出现了。 纤毛缺陷导致多器官疾病，如Bardet-Biedl，Meckel Gruber和Joubert 综合征纤毛参与多种信号通路，包括脊椎动物Hedgehog 信号传导，这对胚胎发育至关重要，并与某些癌症有关 包括基底细胞癌和髓母细胞瘤， 青少年。G蛋白偶联受体在哺乳动物的传感和信号传导中具有关键作用， 许多受体位于纤毛中。例如，光和气味的感觉发生在纤毛中 基于纤毛的受体与食欲、行为和视觉的控制有关。 因此，睫状体功能障碍导致常见疾病，例如失明、糖尿病和糖尿病。 肥胖该提案的目的是支持年轻科学家参与研究 纤毛生物学和纤毛相关疾病在FASEB夏季研究会议上， 2019年、2021年和2023年的纤毛和鞭毛生物学。 关于纤毛和鞭毛的FASEB会议是关于纤毛的首要国际会议 信号传导和纤毛相关疾病。会议汇集了细胞，分子， 发育生物学家、人类遗传学家、生物化学家、内科科学家和生物药理学家 从纤毛的基础生物学到遗传学和分子生物学， 人类纤毛疾病的机制及其治疗方案。在本提案中，我们 要求资金支持尚未参与这项研究的初级科学家和研究人员， FASEB会议之前，出席作为发言人，以促进该领域的增长和创新。 会议第一天将举行专家会议， 实地会议的高级成员与初级科学家和新来者之间的互动。我们 将邀请来自工业界、基金会、教学学院和出版界的代表， 参加三个关于学术界内外职业发展和选择的讲习班。 这个国际会议是非常好的博士后和早期阶段的研究人员以及参加 作为这一领域的专家与会者的这种组合将进一步实现会议的目标， 产生研究合作，确定该领域的关键挑战，并激励创新 纤毛生物学、纤毛相关疾病及治疗方法的研究。

Abstract Cilia and flagella are thread-like cell organelles protruding from the cell surface into the environment. Long neglected, research on the biology of cilia has seen tremendous growth over the last two decades as their central role in cellular sensing and human disease emerged. Defective cilia cause multi-organ disorders such as Bardet-Biedl, Meckel Gruber, and Joubert syndrome. Cilia participate in several signaling pathways including vertebrate Hedgehog signaling, which is critical for embryonic development and has been implicated in certain cancers including basal cell carcinomas and medulloblastomas, the most common brain tumor in juveniles. G-protein coupled receptors have key roles in mammalian sensing and signaling and many of the receptors are located in cilia. Sensing of light and odors, for example, occurs in cilia and cilia-based receptors have been implicated in the control of appetite, behavior and vision. Thus, ciliary dysfunction contributes to common diseases such as blindness, diabetes and obesity. The purpose of this proposal is to support the participation of junior scientists studying cilia biology and cilia-related disease at the FASEB Summer Research Conferences on the Biology of Cilia and Flagella in 2019, 2021 and 2023. The FASEB conference on cilia and flagella is the premier international meeting on cilia signaling and cilia-related disease. The conference brings together cell, molecular, and developmental biologists, human geneticists, biochemists, physician scientists and biophysicists with interests ranging from the fundamental biology of cilia to the genetics and molecular mechanisms of human cilia-based diseases and their treatment options. In this proposal, we request funds to support junior scientists and investigators, who have not participated in this FASEB conference before, to attend as speakers to promote growth and innovation of the field. A Meet-the-Experts session will be held at the first day of the meeting to facilitate informal interaction between senior members of the field meet and junior scientists and newcomers. We will invite representatives from industry, foundations, teaching colleges and publishing to participate in three workshops on career development and options in and outside of academia. This international meeting is very well attended by postdocs and early stage investigators as well as established experts in the field. This mix of attendees will further the goal of the conference of generate research collaborations, identify key challenges in the field, and stimulate innovative research on the biology of cilia, cilia-related disease and therapies.