FASEB SRC on The Biology of Cilia and Flagella

摘要 纤毛和鞭毛是线状细胞器，从细胞表面突出到细胞内。 环境。长期被忽视的纤毛生物学研究在过去的几年里取得了巨大的增长。 在过去的二十年里，随着它们在细胞传感和人类疾病中的核心作用出现。 纤毛缺陷可引起多器官疾病，如Bardet-Biedl、Meckel Gruber和Joubert 综合症。纤毛参与多种信号通路，包括脊椎动物刺猬 信号，这是胚胎发育的关键，并与某些癌症有关 包括基底细胞癌和髓母细胞瘤，是全世界最常见的脑肿瘤 青少年。G蛋白偶联受体在哺乳动物的感觉和信号转导中起关键作用 许多受体位于纤毛中。例如，对光和气味的感觉发生在纤毛上。 纤毛受体被认为与食欲、行为和视觉的控制有关。 因此，睫状体功能障碍会导致常见的疾病，如失明、糖尿病和 肥胖。这项建议的目的是支持初级科学家参与研究 纤毛生物学和纤毛相关疾病在FASEB夏季研究会议上的报告 2019年、2021年和2023年纤毛和鞭毛的生物学。 关于纤毛和鞭毛的国际会议是关于纤毛的首要国际会议。 信号和纤毛相关疾病。这次会议汇集了细胞、分子和 发育生物学家、人类遗传学家、生物化学家、内科科学家和生物物理学家 兴趣范围从纤毛的基础生物学到遗传学和分子 基于纤毛的人类疾病的机制及其治疗选择。在这项提案中，我们 申请资金支持初级科学家和研究人员，他们没有参与这项工作 在FASE会议之前，以演讲者的身份出席，促进领域的增长和创新。 会议第一天将举行专家见面会，以便利非正式会议。 该领域的资深成员与初级科学家和新手之间的互动。我们 将邀请来自行业、基金会、教学学院和出版业的代表 参加三个关于学术界内外职业发展和选择的研讨会。 参加这次国际会议的博士后和早期研究人员也很多。 作为该领域的老牌专家。与会者的这种混合将推动会议的目标 促进研究协作，确定该领域的关键挑战，并激发创新 纤毛生物学、纤毛相关疾病及治疗研究。

Abstract Cilia and flagella are thread-like cell organelles protruding from the cell surface into the environment. Long neglected, research on the biology of cilia has seen tremendous growth over the last two decades as their central role in cellular sensing and human disease emerged. Defective cilia cause multi-organ disorders such as Bardet-Biedl, Meckel Gruber, and Joubert syndrome. Cilia participate in several signaling pathways including vertebrate Hedgehog signaling, which is critical for embryonic development and has been implicated in certain cancers including basal cell carcinomas and medulloblastomas, the most common brain tumor in juveniles. G-protein coupled receptors have key roles in mammalian sensing and signaling and many of the receptors are located in cilia. Sensing of light and odors, for example, occurs in cilia and cilia-based receptors have been implicated in the control of appetite, behavior and vision. Thus, ciliary dysfunction contributes to common diseases such as blindness, diabetes and obesity. The purpose of this proposal is to support the participation of junior scientists studying cilia biology and cilia-related disease at the FASEB Summer Research Conferences on the Biology of Cilia and Flagella in 2019, 2021 and 2023. The FASEB conference on cilia and flagella is the premier international meeting on cilia signaling and cilia-related disease. The conference brings together cell, molecular, and developmental biologists, human geneticists, biochemists, physician scientists and biophysicists with interests ranging from the fundamental biology of cilia to the genetics and molecular mechanisms of human cilia-based diseases and their treatment options. In this proposal, we request funds to support junior scientists and investigators, who have not participated in this FASEB conference before, to attend as speakers to promote growth and innovation of the field. A Meet-the-Experts session will be held at the first day of the meeting to facilitate informal interaction between senior members of the field meet and junior scientists and newcomers. We will invite representatives from industry, foundations, teaching colleges and publishing to participate in three workshops on career development and options in and outside of academia. This international meeting is very well attended by postdocs and early stage investigators as well as established experts in the field. This mix of attendees will further the goal of the conference of generate research collaborations, identify key challenges in the field, and stimulate innovative research on the biology of cilia, cilia-related disease and therapies.