Caregiving effects on the early development of infant brain-behavior relationships

照顾对婴儿大脑行为关系早期发育的影响

• 批准号: 10426257
• 负责人: ALISON E HIPWELL
• 金额: $ 64.43万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10426257
• 关键词: Age; Amygdaloid structure; Anisotropy; Behavior; Behavioral; Brain; Buffers; Caregivers; Child; Child Welfare; Clinical; Corpus Callosum; Corpus striatum structure; Data; Development; Diffusion; Early Intervention; Emotional; Emotional Stability; Family; Future; Health; Hippocampus (Brain); Human; Image; Infant; Infant Development; Inferior; Insula of Reil; Intervention; Lateral; Life; Link; Longitudinal Studies; MRI Scans; Maternal Behavior; Measures; Medial; Methodology; Neurobiology; Pattern; Personal Satisfaction; Postpartum Period; Process; Psychopathology; Regulation; Reporting; Research; Rest; Risk; Risk Factors; Role; Sampling; Shapes; Sleep; Structure; Symptoms; Thalamic structure; To specify; Work; base; behavioral outcome; behavioral study; brain behavior; caregiver functioning; caregiving; clinically relevant; emotion dysregulation; emotion regulation; emotional behavior; functional outcomes; gray matter; improved; infancy; mental state; multimodal neuroimaging; neural circuit; neural network; neurobehavioral; neuroregulation; primary caregiver; prospective; relating to nervous system; sex; white matter

ABSTRACT The rapid development of the human brain in the first years of life determines critical brain-behavior relationships that are likely to set the stage for future clinical and functional outcomes. In parallel, infant behavioral studies show that high levels of negative emotionality (NE), low positive emotionality (PE), and emotional dysregulation are early risk factors for subsequent child behavioral and emotional problems. Emerging research also indicates a critical role of caregiving in shaping early brain-behavior relationships. Yet, little is known about the interface between functioning and structure in neural circuitries underlying emotional reactivity and early emotional regulation, the behavioral manifestations of these circuitries, and the ways in which caregiving quality might influence this neurobehavioral development. Our preliminary data (R21MH106570) show significant links between compromised white matter and intrinsic (resting state) functional connectivity in prefrontal cortical-subcortical emotional reactivity/ regulation circuitry in 3-month infants and independent observations of: 1) high NE relative to PE assessed concurrently; and 2) emotional dysregulation assessed 6 months later. We have also shown that insensitive maternal behavior at 3 months is associated with disrupted relationships between infant brain structure and intrinsic functional connectivity, and NE and PE. We now propose a larger-scale, longitudinal study of 120 infants, which will examine the predictive utility of infant brain structure and intrinsic functional connectivity at 3 and 9 months, and changes between 3 and 9 months, on trajectories of NE, PE and emotional regulation from 3 to 18 months, and the impact of caregiving on these developing brain-behavior relationships. Infants will be sampled across the spectrum of risk for emotionality and emotional dysregulation, as a function of caregiver report of emotional instability in the postpartum period. Infants will undergo MRI scans during sleep at 3 and 9 months. PE, NE and emotional regulation will be measured at 3, 9 and 18 months, via primary caregiver reports and independent observations. Caregiving behavior will also be assessed in separate sessions with the infant at 3, 9 and 18 months. We aim to examine: 1) prospective relationships among neural circuitry structure and intrinsic functional connectivity at 3 and 9 months, and change from 3 to 9 months, and: 3-18 month changes in emotional reactivity and regulation; and 2) the influence of caregiving on these brain-behavior relationships across the first 18 months of life. Exploratory analyses will also explore the effect of the sex of the infant upon infant brain-behavior relationships. Elucidating these brain-behavior relationships early in life will help identify objective neural markers among at-risk children before clinical problems emerge, and provide targets for new interventions to improve the health and well-being of children at risk for future psychopathology.

摘要 人类大脑在生命的最初几年的快速发展决定了关键的大脑行为 可能为未来的临床和功能结果奠定基础的关系。同时，婴儿 行为研究表明，高水平的消极情绪(NE)，低水平的积极情绪(PE)，以及 情绪失调是随后儿童行为和情绪问题的早期危险因素。 新出现的研究还表明，照顾在塑造早期大脑-行为关系方面发挥着关键作用。然而， 关于情绪神经回路中的功能和结构之间的接口，我们知之甚少 反应性和早期情绪调节，这些回路的行为表现，以及 哪种照顾品质可能会影响这种神经行为的发展。我们的初步数据 (R21MH106570)显示受损的脑白质和内在(静息状态)之间的显著联系 3个月前额叶皮质-皮质下情绪反应/调节回路的功能连接 婴儿和独立观察：1)高NE与PE同时评估；以及2)情绪 6个月后评估失调症。我们还表明，3个月大的母亲行为迟钝 与婴儿大脑结构和内在功能连接之间的关系中断有关，以及 Ne和Pe。我们现在建议对120名婴儿进行一项更大规模的纵向研究，该研究将检验 3个月和9个月婴儿大脑结构和内在功能连接的效用，以及3个月和9个月之间的变化 9个月对3个月至18个月的NE、PE和情绪调节的影响 照顾这些发展中的大脑-行为关系。婴儿将在不同的范围内进行抽样 情绪性和情绪调节失调的风险，作为照顾者报告的情绪不稳定的功能 产后期。婴儿将在3个月和9个月大的时候在睡眠中接受核磁共振扫描。体育、NE和情感 监管将在3个月、9个月和18个月时通过主要照顾者报告和独立报告进行衡量 观察。照顾行为也将在3岁、9岁和18岁时分别与婴儿进行评估 月份。我们的目标是检查：1)神经回路结构和内在关系之间的预期关系 3个月和9个月的功能连接性，从3个月到9个月的变化，以及：3-18个月的变化 情绪反应和调节；2)照顾对这些大脑-行为关系的影响 在生命的前18个月。探索性分析还将探索婴儿性别对 婴儿大脑-行为关系。在生命早期阐明这些大脑-行为关系将有助于识别 目的在临床问题出现前对高危儿童进行神经标志物的检测，为新的研究提供靶点。 改善未来精神病高危儿童的健康和福祉的干预措施。