Caregiving effects on the early development of infant brain-behavior relationships

照顾对婴儿大脑行为关系早期发育的影响

• 批准号: 10205962
• 负责人: ALISON E HIPWELL
• 金额: $ 70.03万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10205962
• 关键词: Age; Amygdaloid structure; Anisotropy; Behavior; Behavioral; Brain; Buffers; Caregivers; Child; Child Welfare; Clinical; Corpus Callosum; Corpus striatum structure; Data; Development; Diffusion; Early Intervention; Emotional; Emotional Stability; Family; Future; Health; Hippocampus (Brain); Human; Image; Infant; Infant Development; Inferior; Insula of Reil; Intervention; Lateral; Life; Link; Longitudinal Studies; MRI Scans; Maternal Behavior; Measures; Medial; Methodology; Neurobiology; Pattern; Personal Satisfaction; Postpartum Period; Process; Psychopathology; Regulation; Reporting; Research; Rest; Risk; Risk Factors; Role; Sampling; Shapes; Sleep; Structure; Symptoms; Thalamic structure; To specify; Work; base; behavioral outcome; behavioral study; brain behavior; caregiver functioning; caregiving; clinically relevant; emotion dysregulation; emotion regulation; emotional behavior; functional outcomes; gray matter; improved; infancy; mental state; multimodality; neural circuit; neural network; neurobehavioral; neuroimaging; neuroregulation; primary caregiver; prospective; relating to nervous system; sex; white matter

ABSTRACT The rapid development of the human brain in the first years of life determines critical brain-behavior relationships that are likely to set the stage for future clinical and functional outcomes. In parallel, infant behavioral studies show that high levels of negative emotionality (NE), low positive emotionality (PE), and emotional dysregulation are early risk factors for subsequent child behavioral and emotional problems. Emerging research also indicates a critical role of caregiving in shaping early brain-behavior relationships. Yet, little is known about the interface between functioning and structure in neural circuitries underlying emotional reactivity and early emotional regulation, the behavioral manifestations of these circuitries, and the ways in which caregiving quality might influence this neurobehavioral development. Our preliminary data (R21MH106570) show significant links between compromised white matter and intrinsic (resting state) functional connectivity in prefrontal cortical-subcortical emotional reactivity/ regulation circuitry in 3-month infants and independent observations of: 1) high NE relative to PE assessed concurrently; and 2) emotional dysregulation assessed 6 months later. We have also shown that insensitive maternal behavior at 3 months is associated with disrupted relationships between infant brain structure and intrinsic functional connectivity, and NE and PE. We now propose a larger-scale, longitudinal study of 120 infants, which will examine the predictive utility of infant brain structure and intrinsic functional connectivity at 3 and 9 months, and changes between 3 and 9 months, on trajectories of NE, PE and emotional regulation from 3 to 18 months, and the impact of caregiving on these developing brain-behavior relationships. Infants will be sampled across the spectrum of risk for emotionality and emotional dysregulation, as a function of caregiver report of emotional instability in the postpartum period. Infants will undergo MRI scans during sleep at 3 and 9 months. PE, NE and emotional regulation will be measured at 3, 9 and 18 months, via primary caregiver reports and independent observations. Caregiving behavior will also be assessed in separate sessions with the infant at 3, 9 and 18 months. We aim to examine: 1) prospective relationships among neural circuitry structure and intrinsic functional connectivity at 3 and 9 months, and change from 3 to 9 months, and: 3-18 month changes in emotional reactivity and regulation; and 2) the influence of caregiving on these brain-behavior relationships across the first 18 months of life. Exploratory analyses will also explore the effect of the sex of the infant upon infant brain-behavior relationships. Elucidating these brain-behavior relationships early in life will help identify objective neural markers among at-risk children before clinical problems emerge, and provide targets for new interventions to improve the health and well-being of children at risk for future psychopathology.

摘要 人类大脑在生命最初几年的快速发育决定了关键的大脑行为 这些关系可能为未来的临床和功能结局奠定基础。与此同时，婴儿 行为研究表明，高水平的消极情绪（NE），低水平的积极情绪（PE）， 情绪失调是儿童随后出现行为和情绪问题的早期危险因素。 新兴的研究也表明，在塑造早期的大脑行为关系中，认知起着至关重要的作用。然而， 关于情感神经回路中功能和结构之间的界面， 反应性和早期情绪调节，这些电路的行为表现，以及 哪种学习质量可能会影响这种神经行为的发展。我们的初步数据 （R21 MH 106570）显示受损的白色物质与内在（静息状态）之间存在显著联系 3个月时前额叶皮质-皮质下情绪反应/调节回路的功能连接 婴儿和独立观察：1）同时评估相对于PE的高NE;和2）情绪 6个月后评估失调。我们还表明，3个月大时母亲的不敏感行为， 与婴儿大脑结构和内在功能连接之间的关系中断有关， NE和PE。我们现在提出了一个更大规模的，纵向研究120名婴儿，这将检查预测 婴儿大脑结构和内在功能连接在3个月和9个月时的效用，以及3个月之间的变化 和9个月，NE，PE和情绪调节的轨迹从3到18个月，以及 这些发展中的大脑-行为关系。婴儿将被抽样调查， 情绪化和情绪失调的风险，作为护理人员报告的情绪不稳定的函数 产后时期婴儿将在3个月和9个月的睡眠期间接受MRI扫描。PE、NE和情绪 将在3、9和18个月时通过主要护理人员报告和独立的 意见。还将在3岁、9岁和18岁时对婴儿进行单独的护理行为评估 个月我们的目的是研究：1）神经回路结构和内在的前瞻性关系 3个月和9个月时的功能连接，以及3个月至9个月的变化，以及：3-18个月时的变化 情绪反应和调节; 2）情绪对这些大脑行为关系的影响 在生命的前18个月。探索性分析还将探索婴儿性别对 婴儿的大脑行为关系在生命早期阐明这些大脑行为关系将有助于识别 在临床问题出现之前，在高危儿童中进行客观的神经标记，并为新的 干预措施，以改善未来有精神病理风险的儿童的健康和福祉。