Caregiving effects on the early development of infant brain-behavior relationships

照顾对婴儿大脑行为关系早期发育的影响

基本信息

项目摘要

ABSTRACT The rapid development of the human brain in the first years of life determines critical brain-behavior relationships that are likely to set the stage for future clinical and functional outcomes. In parallel, infant behavioral studies show that high levels of negative emotionality (NE), low positive emotionality (PE), and emotional dysregulation are early risk factors for subsequent child behavioral and emotional problems. Emerging research also indicates a critical role of caregiving in shaping early brain-behavior relationships. Yet, little is known about the interface between functioning and structure in neural circuitries underlying emotional reactivity and early emotional regulation, the behavioral manifestations of these circuitries, and the ways in which caregiving quality might influence this neurobehavioral development. Our preliminary data (R21MH106570) show significant links between compromised white matter and intrinsic (resting state) functional connectivity in prefrontal cortical-subcortical emotional reactivity/ regulation circuitry in 3-month infants and independent observations of: 1) high NE relative to PE assessed concurrently; and 2) emotional dysregulation assessed 6 months later. We have also shown that insensitive maternal behavior at 3 months is associated with disrupted relationships between infant brain structure and intrinsic functional connectivity, and NE and PE. We now propose a larger-scale, longitudinal study of 120 infants, which will examine the predictive utility of infant brain structure and intrinsic functional connectivity at 3 and 9 months, and changes between 3 and 9 months, on trajectories of NE, PE and emotional regulation from 3 to 18 months, and the impact of caregiving on these developing brain-behavior relationships. Infants will be sampled across the spectrum of risk for emotionality and emotional dysregulation, as a function of caregiver report of emotional instability in the postpartum period. Infants will undergo MRI scans during sleep at 3 and 9 months. PE, NE and emotional regulation will be measured at 3, 9 and 18 months, via primary caregiver reports and independent observations. Caregiving behavior will also be assessed in separate sessions with the infant at 3, 9 and 18 months. We aim to examine: 1) prospective relationships among neural circuitry structure and intrinsic functional connectivity at 3 and 9 months, and change from 3 to 9 months, and: 3-18 month changes in emotional reactivity and regulation; and 2) the influence of caregiving on these brain-behavior relationships across the first 18 months of life. Exploratory analyses will also explore the effect of the sex of the infant upon infant brain-behavior relationships. Elucidating these brain-behavior relationships early in life will help identify objective neural markers among at-risk children before clinical problems emerge, and provide targets for new interventions to improve the health and well-being of children at risk for future psychopathology.
摘要

项目成果

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ALISON E HIPWELL其他文献

ALISON E HIPWELL的其他文献

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{{ truncateString('ALISON E HIPWELL', 18)}}的其他基金

Mother-Infant Biobehavioral Synchrony and Postpartum Depression
母婴生物行为同步性和产后抑郁症
  • 批准号:
    10582028
  • 财政年份:
    2023
  • 资助金额:
    $ 70.03万
  • 项目类别:
Preconception and prenatal stress effects on cardiovascular disease risk in black women
受孕前和产前应激对黑人女性心血管疾病风险的影响
  • 批准号:
    10451147
  • 财政年份:
    2020
  • 资助金额:
    $ 70.03万
  • 项目类别:
Preconception and prenatal stress effects on cardiovascular disease risk in black women - Diversity Supplement
受孕前和产前压力对黑人女性心血管疾病风险的影响 - Diversity Supplement
  • 批准号:
    10850292
  • 财政年份:
    2020
  • 资助金额:
    $ 70.03万
  • 项目类别:
Preconception and prenatal stress effects on cardiovascular disease risk in black women
受孕前和产前应激对黑人女性心血管疾病风险的影响
  • 批准号:
    10170669
  • 财政年份:
    2020
  • 资助金额:
    $ 70.03万
  • 项目类别:
Preconception and prenatal stress effects on cardiovascular disease risk in black women
受孕前和产前应激对黑人女性心血管疾病风险的影响
  • 批准号:
    10256677
  • 财政年份:
    2020
  • 资助金额:
    $ 70.03万
  • 项目类别:
Preconception and prenatal stress effects on cardiovascular disease risk in black women
受孕前和产前应激对黑人女性心血管疾病风险的影响
  • 批准号:
    10458038
  • 财政年份:
    2020
  • 资助金额:
    $ 70.03万
  • 项目类别:
Caregiving effects on the early development of infant brain-behavior relationships
照顾对婴儿大脑行为关系早期发育的影响
  • 批准号:
    10426257
  • 财政年份:
    2018
  • 资助金额:
    $ 70.03万
  • 项目类别:
Preconception stress exposure: Impact on pregnancy and offspring neurodevelopment
孕前压力暴露:对妊娠和后代神经发育的影响
  • 批准号:
    10004737
  • 财政年份:
    2016
  • 资助金额:
    $ 70.03万
  • 项目类别:
Preconception stress exposure: Impact on pregnancy and offspring neurodevelopment
孕前压力暴露:对妊娠和后代神经发育的影响
  • 批准号:
    10240523
  • 财政年份:
    2016
  • 资助金额:
    $ 70.03万
  • 项目类别:
Resilience to prenatal stress: Implications for offspring health and neurodevelopment
对产前应激的抵抗力:对后代健康和神经发育的影响
  • 批准号:
    10744980
  • 财政年份:
    2016
  • 资助金额:
    $ 70.03万
  • 项目类别:
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