Mother-Infant Biobehavioral Synchrony and Postpartum Depression

母婴生物行为同步性和产后抑郁症

• 批准号: 10582028
• 负责人: ALISON E HIPWELL
• 金额: $ 72.52万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2027-10-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10582028
• 关键词: Affect; Affective; Anterior; Behavior; Behavior Therapy; Behavioral; Brain; Brain region; Case/Control Studies; Child; Clinical; Code; Cognitive; Data; Development; Disease; Emotional; Environment; Family; Film; Future; Home; Home environment; Home visitation; Infant; Infant Development; Informal Social Control; Intervention; Interview; Investigation; Joints; Knowledge; Lateral; Life; Measures; Medial; Mediating; Mental Depression; Methods; Modeling; Mothers; Near-Infrared Spectroscopy; Neurophysiology - biologic function; Parents; Pathway interactions; Physiological; Physiology; Play; Positive Valence; Postpartum Depression; Postpartum Period; Prefrontal Cortex; Process; Questionnaires; Recording of previous events; Recovery; Reporting; Research; Risk; Sampling; Severities; Shapes; System; Testing; Visit; Woman; biobehavior; caregiving; case control; depressive symptoms; design; early childhood; emotion dysregulation; emotion regulation; experience; improved; maternal depression; mentalization; negative affect; neural; neuroimaging; portability; postpartum care; preventive intervention; prospective; recruit; response; screening; social; social cognition; stressor; tool

ABSTRACT Infant brain and regulatory systems develop rapidly in the first months of life and set the stage for healthy behavioral and emotional development. Research shows that these systems are shaped, to a large extent, by the postpartum caregiving environment. In particular, mother-infant interactions that are characterized by shared positive affect and mutually responsive behavior facilitate the development of infant emotional self-regulation via mother-infant co-regulation of homeostatic and neural systems. In the context of postpartum depression (PPD) however, growing evidence suggests that these processes are disrupted with potentially long-term adverse implications for the infant. However, several critical gaps remain. First, little is known about the neural substrates of dyadic co-regulation despite the promise of recent advances in portable neuroimaging tools (i.e., near-infrared spectroscopy [NIRS] hyperscanning). Second, although positively valenced systems are fundamental to healthy adjustment and to strengths-based parent-child behavioral interventions, research has focused predominantly on negative affect and deficit models. Third, there is a lack of longitudinal research examining developmental change in co-regulatory behaviors and PPD severity that could inform preventive interventions. The proposed study aims to fill these gaps, and is supported by preliminary proof-of-concept data that mothers and children show concordant responding in medial frontal and lateral frontal regions, which are implicated in social cognition, bonding, and mentalizing, and that positive synchronous interactions heighten these concordant responses. The Specific Aims are to: 1) Characterize mother-infant bio-behavioral synchrony (matching of affective behavior and brain response) at 3 months postpartum; 2) Examine concurrent and prospective associations between PPD severity and mother-infant positive bio-behavioral synchrony; and 3) Examine the extent to which improvements in mother-infant positive bio-behavioral synchrony predict infant emotional regulation. Using a case-control design, we will recruit 176 women endorsing PPD (n=140 at study completion) and 87 women with no prior history of depression (n=70 at study completion) with their 3-month-old infants and conduct three research visits in the home environment to increase participation of difficult-to-reach and vulnerable families. We will assess bio-behavioral synchrony in mother-infant face-to-face interactions at 3-, 6- and 9-months during simultaneous mother-infant NIRS. Micro-analytic coding will provide moment-to-moment measures of positive and negative affect and contingent responding, and NIRS will provide measures of dyadic concordance in mother and infant anterior medial and lateral prefrontal cortical activity. Change in PPD will be assessed via clinical interviews at each home visit, in addition to monthly screening from 3 to 9 months. Infant emotional self-regulation will be assessed at 9 months via independent observations and maternal report.

摘要 婴儿的大脑和调节系统在出生的头几个月迅速发育，为健康奠定了基础 行为和情感发展。研究表明，这些系统在很大程度上是由 产后护理环境。特别是，以共享为特征的母婴互动 积极情绪和相互反应行为通过促进幼儿情绪自我调节的发展 母婴对体内平衡和神经系统的共同调节。产后抑郁症(PPD) 然而，越来越多的证据表明，这些过程受到了潜在的长期不利影响。 对婴儿的影响。然而，仍然存在几个关键差距。首先，人们对神经基质知之甚少。 尽管便携式神经成像工具(即近红外)的最新进展前景看好，但二元共同调节的前景 光谱学[NIR]超扫描)。第二，尽管正价体系是健康的基础 调整和基于优势的亲子行为干预，研究主要集中在 关于负面情感和赤字模型。第三，缺乏考察发展的纵向研究。 协同调节行为和产后抑郁严重程度的变化可以为预防性干预提供信息。建议数 这项研究旨在填补这些空白，并得到了初步概念验证数据的支持，即母亲和孩子 在与社会认知有关的额叶内侧和外侧区域，表现出一致的反应。 联结和意念，以及积极的同步互动增强了这些和谐的反应。这个 具体目标是：1)表征母婴生物行为同步性(情感行为和 产后3个月的脑部反应)；2)研究产后抑郁与产后抑郁的相关性 严重程度和母婴积极生物行为同步性；以及3)检查改善的程度 在母婴中，积极的生物行为同步性可以预测婴儿的情绪调节。使用病例对照 设计，我们将招募176名支持PPD的女性(140名在研究完成时)和87名以前没有支持PPD的女性 3个月大婴儿的抑郁症病史(研究完成时为70例)，并进行三次研究访问 在家庭环境中增加难以接触和脆弱家庭的参与。我们将评估 3个月、6个月和9个月时母婴面对面互动的生物行为同步性 母婴近红外光谱。微分析编码将提供积极和消极的时刻测量 情感和应急反应，NIRS将提供母婴二元一致性的测量 前、内侧和外侧前额叶皮质活动。PPD的变化将通过临床访谈进行评估 每次家访，除每月筛查3至9个月外。婴幼儿情绪自我调节会 通过独立观察和母体报告在9个月时进行评估。