Antioxidative Microelectrodes to Improve Neural Recording Performance
Antioxidative Microelectrodes to Improve Neural Recording Performance
批准号:
10426077
负责人:
Jeffrey R Capadona
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-07-01 至 2022-12-31
关键词:
AcuteAmyotrophic Lateral SclerosisAnimalsAnti-Inflammatory AgentsAntioxidantsBiologicalBiological ProductsBiomimeticsBloodBlood - brain barrier anatomyBrainCellsCessation of lifeChemicalsChemistryChronicClinicClinical TrialsCommunitiesComputersConsensusCorrosionDataDetectionDevicesDisabled PersonsElectrodesElectrophysiology (science)FailureFutureGliosisHistologicHistologyHumanImplantIn VitroIndividualInflammationInflammatoryInflammatory ResponseInjuryInvadedLengthLimb structureLiteratureLong-Term EffectsLongevityMediatingMichiganMicroelectrodesMinocyclineModelingModificationMuscleNerve DegenerationNeuraxisNeuronsNeuropeptidesOxidative StressParalysedPatientsPeptidesPerformancePopulationProcessProteinsQuadriplegiaQuality of lifeRattusReactive Oxygen SpeciesReportingResearchRoboticsRoentgen RaysRoleSelf-Help DevicesSerum ProteinsSignal TransductionSiliconSourceSpectrum AnalysisSpinal cord injuryStrokeSurfaceTechnologyThinkingTimeTissuesTranslationsTraumaUtahVeteransVolitionarmblood-brain barrier permeabilizationbrain computer interfacebrain machine interfaceclinically relevantcostdesignelectric impedanceextracellularimplantationimprovedin vivoinnovationnervous system disorderneuroinflammationneuroprotectionnovelparylene Cpreservationpreventrelating to nervous systemresponserobot controlside effectsurface coating
中文摘要
用皮质内微电极记录人类患者神经元的电信号
英文摘要
Electrical signals recorded from the neurons of human patients by intracortical microelectrodes have
been used to communicate with computers, control robotic limbs, and recently in a VA study, control the
patient's own arm. The signal quality and the length of time that useful signals can be recorded are
inconsistent. The consensus view of the community is that the inflammatory response of neural tissue
that surrounds the microelectrodes, at least in part, compromises electrode reliability. Several studies
have demonstrated the connection between neuroinflammation and microelectrode performance.
Inflammation is initiated when inflammatory cells recognize foreign biologics (i.e. damaged/infiltrating
proteins and cells). Serum proteins and blood-derived cells invade the central nervous system following
microelectrode implantation and aggravate the neuroinflammatory response. Cells and tissue are
damaged from the trauma of microelectrode implantation. At the microelectrode surface, accumulation
of pro-inflammatory molecules causes neuronal degeneration and increases the permeability of the
blood-brain barrier, self-perpetuating the process.
We are exploring several antioxidative approaches to improve microelectrode reliability. Our
preliminary data indicates antioxidative approaches as a highly promising strategy. Specifically, we have
used a variety of antioxidant treatments to demonstrate a reduction in intracortical microelectrode-
mediated oxidative stress and preserve neuron viability. Our newest strategy for improving intracortical
recording reliability is our biomimetic antioxidative coating. Thus far, we have shown improvements in
acute recording on one electrode type. Chronic recording performance and translation to additional
electrode types is a priority. Our coating was developed as a platform technology that could be applied
to any intracortical microelectrode substrate with simple modifications to the attachment chemistry. Our
initial efforts focused on planar silicon substrates for ease of characterization, cost, and their recent
popularity in the literature. Preliminary results suggest that our antioxidative-coated microelectrodes
reduce the initial inflammatory response, preserve neuron populations adjacent to the electrodes, and
improve initial recording quality. However, we have yet to demonstrate that the coatings can be applied
to other popular microelectrode types, such as those used in the clinic. We also still need to characterize
the long-term effects of our coatings on both neuroinflammation and the reliability of recording
performance. The innovation of this proposal is in the application of a platform technology to effectively
minimize two of the leading causes of intracortical microelectrode failure: materials damage and
biological damage. This study is designed to answer clinically-relevant questions, and has the potential
to directly impact ongoing and future clinical trials by the completion of the proposed study.
期刊论文(5)
专著(0)
科研奖励(0)
会议论文
DOI:
10.3390/mi14101902
发表时间:
2023-10-04
期刊:
Micromachines
影响因子:
3.4
作者:
[Hoeferlin GF, Bajwa T, Olivares H, Zhang J, Druschel LN, Sturgill BS, Sobota M, Boucher P, Duncan J, Hernandez-Reynoso AG, Cogan SF, Pancrazio JJ, Capadona JR]
通讯作者:
Capadona JR
DOI:
10.1016/j.actbio.2023.07.038
发表时间:
2023-07
期刊:
Acta biomaterialia
影响因子:
9.7
作者:
[Sydney Song;Lindsey N. Druschel;E. Chan;J. Capadona]
通讯作者:
Sydney Song;Lindsey N. Druschel;E. Chan;J. Capadona
DOI:
10.29245/2578-3009/2018/4.1157
发表时间:
2018-01-01
期刊:
Journal of immunological sciences
影响因子:
--
作者:
[Bedell, Hillary W, Capadona, Jeffrey R]
通讯作者:
Capadona, Jeffrey R
Optimizing Delivery of a Known Therapeutic Agent, Dexamethasone, to Improve Microelectrode Recording Performance
-
批准号:10418649
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2020
-
负责人:Jeffrey R Capadona
-
依托单位:
Optimizing Delivery of a Known Therapeutic Agent, Dexamethasone, to Improve Microelectrode Recording Performance
-
批准号:10642761
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2020
-
负责人:Jeffrey R Capadona
-
依托单位:
Optimizing Delivery of a Known Therapeutic Agent, Dexamethasone, to Improve Microelectrode Recording Performance
-
批准号:10217285
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2020
-
负责人:Jeffrey R Capadona
-
依托单位:
RR&D Research Career Scientist Award Application
-
批准号:10060750
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2019
-
负责人:Jeffrey R Capadona
-
依托单位:
RR&D Research Career Scientist Award Application
-
批准号:10533265
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2019
-
负责人:Jeffrey R Capadona
-
依托单位:
RR&D Research Career Scientist Award Application
-
批准号:10311087
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2019
-
负责人:Jeffrey R Capadona
-
依托单位:
Characterizing and Mitigating the Role of Oxidative Damage in Microelectrode Failure
-
批准号:10599364
-
项目类别:
-
资助金额:$58.11万
-
财政年份:2019
-
负责人:Jeffrey R Capadona
-
依托单位:
Hybrid Drug-Eluting Microfluidic Neural Probe for Chronic Drug Infusion
-
批准号:10356848
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2019
-
负责人:Jeffrey R Capadona
-
依托单位:
Characterizing and mitigating the role of oxidative damage in microelectrode failure
-
批准号:10561933
-
项目类别:
-
资助金额:$11.42万
-
财政年份:2019
-
负责人:Jeffrey R Capadona
-
依托单位:
Hybrid Drug-Eluting Microfluidic Neural Probe for Chronic Drug Infusion
-
批准号:10840055
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2019
-
负责人:Jeffrey R Capadona
-
依托单位:
Senior Research Career Scientist
-
批准号:10749218
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2019
-
负责人:Jeffrey R Capadona
-
依托单位:
Characterizing and Mitigating the Role of Oxidative Damage in Microelectrode Failure
-
批准号:10374024
-
项目类别:
-
资助金额:$58.21万
-
财政年份:2019
-
负责人:Jeffrey R Capadona
-
依托单位:
Characterizing and mitigating the role of oxidative damage in microelectrode failure
-
批准号:9894871
-
项目类别:
-
资助金额:$63.6万
-
财政年份:2019
-
负责人:Jeffrey R Capadona
-
依托单位:
Characterizing and Mitigating the Role of Oxidative Damage in Microelectrode Failure
-
批准号:10812144
-
项目类别:
-
资助金额:$11.42万
-
财政年份:2019
-
负责人:Jeffrey R Capadona
-
依托单位:
Antioxidative Microelectrodes to Improve Neural Recording Performance
-
批准号:10179504
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2018
-
负责人:Jeffrey R Capadona
-
依托单位:
Resveratrol Prevents Microelectrode Mediated Neurodegeneration
-
批准号:9001843
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2014
-
负责人:Jeffrey R Capadona
-
依托单位:
Resveratrol Prevents Microelectrode Mediated Neurodegeneration
-
批准号:9253032
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2014
-
负责人:Jeffrey R Capadona
-
依托单位:
CD14 facilitates neural device integration and performance
-
批准号:8632462
-
项目类别:
-
资助金额:$45.05万
-
财政年份:2013
-
负责人:Jeffrey R Capadona
-
依托单位:
CD14 facilitates neural device integration and performance
-
批准号:8875788
-
项目类别:
-
资助金额:$45.05万
-
财政年份:2013
-
负责人:Jeffrey R Capadona
-
依托单位:
CD14 facilitates neural device integration and performance
-
批准号:8729034
-
项目类别:
-
资助金额:$44.6万
-
财政年份:2013
-
负责人:Jeffrey R Capadona
-
依托单位:
海外基金