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Antioxidative Microelectrodes to Improve Neural Recording Performance

抗氧化微电极可提高神经记录性能

基本信息

批准号：
10426077
负责人：
Jeffrey R Capadona
金额：
--
依托单位：
LOUIS STOKES CLEVELAND VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2022-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10426077
关键词：
Acute Amyotrophic Lateral Sclerosis Animals Anti-Inflammatory Agents Antioxidants Biological Biological Products Biomimetics Blood Blood - brain barrier anatomy Brain Cells Cessation of life Chemicals Chemistry Chronic Clinic Clinical Trials Communities Computers Consensus Corrosion Data Detection Devices Disabled Persons Electrodes Electrophysiology (science)Failure Future Gliosis Histologic Histology Human Implant In Vitro Individual Inflammation Inflammatory Inflammatory Response Injury Invaded Length Limb structure Literature Long-Term Effects Longevity Mediating Michigan Microelectrodes Minocycline Modeling Modification Muscle Nerve Degeneration Neuraxis Neurons Neuropeptides Oxidative Stress Paralysed Patients Peptides Performance Population Process Proteins Quadriplegia Quality of life Rattus Reactive Oxygen Species Reporting Research Robotics Roentgen Rays Role Self-Help Devices Serum Proteins Signal Transduction Silicon Source Spectrum Analysis Spinal cord injury Stroke Surface Technology Thinking Time Tissues Translations Trauma Utah Veterans Volition arm blood-brain barrier permeabilization brain computer interface brain machine interface clinically relevant cost design electric impedance extracellular implantation improved in vivo innovation nervous system disorder neuroinflammation neuroprotection novel parylene C preservation prevent relating to nervous system response robot control side effect surface coating

项目摘要

Electrical signals recorded from the neurons of human patients by intracortical microelectrodes have been used to communicate with computers, control robotic limbs, and recently in a VA study, control the patient's own arm. The signal quality and the length of time that useful signals can be recorded are inconsistent. The consensus view of the community is that the inflammatory response of neural tissue that surrounds the microelectrodes, at least in part, compromises electrode reliability. Several studies have demonstrated the connection between neuroinflammation and microelectrode performance. Inflammation is initiated when inflammatory cells recognize foreign biologics (i.e. damaged/infiltrating proteins and cells). Serum proteins and blood-derived cells invade the central nervous system following microelectrode implantation and aggravate the neuroinflammatory response. Cells and tissue are damaged from the trauma of microelectrode implantation. At the microelectrode surface, accumulation of pro-inflammatory molecules causes neuronal degeneration and increases the permeability of the blood-brain barrier, self-perpetuating the process. We are exploring several antioxidative approaches to improve microelectrode reliability. Our preliminary data indicates antioxidative approaches as a highly promising strategy. Specifically, we have used a variety of antioxidant treatments to demonstrate a reduction in intracortical microelectrode- mediated oxidative stress and preserve neuron viability. Our newest strategy for improving intracortical recording reliability is our biomimetic antioxidative coating. Thus far, we have shown improvements in acute recording on one electrode type. Chronic recording performance and translation to additional electrode types is a priority. Our coating was developed as a platform technology that could be applied to any intracortical microelectrode substrate with simple modifications to the attachment chemistry. Our initial efforts focused on planar silicon substrates for ease of characterization, cost, and their recent popularity in the literature. Preliminary results suggest that our antioxidative-coated microelectrodes reduce the initial inflammatory response, preserve neuron populations adjacent to the electrodes, and improve initial recording quality. However, we have yet to demonstrate that the coatings can be applied to other popular microelectrode types, such as those used in the clinic. We also still need to characterize the long-term effects of our coatings on both neuroinflammation and the reliability of recording performance. The innovation of this proposal is in the application of a platform technology to effectively minimize two of the leading causes of intracortical microelectrode failure: materials damage and biological damage. This study is designed to answer clinically-relevant questions, and has the potential to directly impact ongoing and future clinical trials by the completion of the proposed study.

由皮质内微电极记录的人类患者神经元的电信号被用来与计算机通信，控制机械臂，最近在退伍军人事务部的一项研究中，控制病人自己的胳膊。信号质量和可记录有用信号的时间长度为前后不一致。社会各界的共识是，神经组织的炎症反应这至少在一定程度上影响了微电极的可靠性。几项研究已经证明了神经炎症和微电极性能之间的联系。当炎症细胞识别外来生物物质(即受损/渗透)时，炎症就开始了蛋白质和细胞)。血清蛋白和血源性细胞侵袭中枢神经系统微电极植入并加重神经炎性反应。细胞和组织是微电极植入创伤造成的损伤。在微电极表面，积累致炎分子会导致神经元变性并增加血管通透性血脑屏障，自我延续这一过程。我们正在探索几种抗氧化方法来提高微电极的可靠性。我们的初步数据表明，抗氧化方法是一种非常有希望的策略。具体来说，我们有使用了各种抗氧化剂治疗来证明皮质内微电极的减少- 介导的氧化应激和保存神经元的活性。我们改善皮质内的最新策略记录可靠性是我们的仿生抗氧化涂层。到目前为止，我们已经在以下方面显示出改进在一种电极型上进行急性记录。长期录制性能和转换为其他电极类型是优先考虑的。我们的涂层是作为一种可应用的平台技术开发的任何皮质内微电极衬底，只需对附着化学进行简单的修改。我们的最初的努力集中在平面硅衬底上，以便于表征、成本和最近的在文学作品中很受欢迎。初步结果表明，我们的抗氧化剂涂层微电极减少最初的炎症反应，保留电极附近的神经元群体，以及提高初始录制质量。然而，我们还没有证明这种涂层可以应用于到其他流行的微电极类型，例如临床上使用的那些。我们还需要刻画我们的涂层对神经炎症和记录可靠性的长期影响性能。这一方案的创新之处在于应用了一种平台技术来有效地尽量减少皮质内微电极失效的两个主要原因：材料损坏和生物破坏。这项研究旨在回答与临床相关的问题，并有可能通过拟议研究的完成直接影响正在进行的和未来的临床试验。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Antioxidant Dimethyl Fumarate Temporarily but Not Chronically Improves Intracortical Microelectrode Performance.

DOI：
10.3390/mi14101902
发表时间：
2023-10-04
期刊：
Micromachines
影响因子：
3.4
作者：
Hoeferlin GF;Bajwa T;Olivares H;Zhang J;Druschel LN;Sturgill BS;Sobota M;Boucher P;Duncan J;Hernandez-Reynoso AG;Cogan SF;Pancrazio JJ;Capadona JR
通讯作者：
Capadona JR

Differential expression of genes involved in the chronic response to intracortical microelectrodes.