West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health

西弗吉尼亚州临床和转化科学研究所：全州范围内的组织，致力于打造卓越研究并吸引社区改善健康

• 批准号: 10876642
• 负责人: Sally Lynn Hodder
• 金额: $ 7.16万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10876642
• 关键词: 2019-nCoV; Academic Medical Centers; Acceleration; Address; Alzheimer' s Disease; Appalachian Region; Award; COVID-19 pandemic; COVID-19 patient; Cardiovascular Diseases; Categories; Chronic Disease; Chronic lung disease; Clinical; Clinical Research; Clinical Sciences; Cohort Studies; Collaborations; Color; Communication; Communities; Community Outreach; County; Development; Environmental Hazards; Exposure to; Funding; Goals; Grant; HIV; Health; Health Resources; Human; Human Resources; Incidence; Institution; Lead; Leadership; Life Expectancy; Malignant Neoplasms; Medical center; National Institute for Occupational Safety and Health; Osteopathic Medicine; Outcome; Policies; Positioning Attribute; Post-Acute Sequelae of SARS-CoV-2 Infection; Primary Care; Productivity; Public Health; Publications; Registries; Research; Research Infrastructure; Research Personnel; Rural Community; Rural Health; Rural Population; Science; Scientist; Site; Substance Use Disorder; Testing; Training; Translational Research; Trust; United States; United States Department of Veterans Affairs; United States National Institutes of Health; West Virginia; Work; addiction; cohort; community engagement; coronavirus disease; equity, diversity, and inclusion; health care service organization; health disparity; improved; medical schools; mortality; new epidemic; next generation; practice-based research network; predictive modeling; programs; reproductive; substance use; success; translational scientist

West Virginia (WV), the only state located entirely in Appalachia, has the lowest life expectancy in the nation and ranks at or near the bottom in many chronic disease categories. The WV Clinical and Translational Science Institute (WVCTSI) was created in 2012 through the initial Institutional Development Award for Clinical and Translational Research (IDeA-CTR) and successfully renewed in 2017. Over the past 9 years, WVCTSI has cultivated and nurtured a highly collaborative, statewide research infrastructure to address the substantial health disparities in WV. Over the past 4 years, WVCTSI productivity has been superb with 1,325 publications, 951 funding applications, and 688 external funding awards totaling $159.3 MM. The WVCTSI’s overarching goal for the next funding cycle is to serve as a transformational force, leading statewide clinical and translational collaborative research that positively impacts health outcomes in WV. We will achieve this goal through the following specific aims: Specific Aim 1 - Build collaborative, productive research infrastructure across WV that substantively contributes to improving WV health outcomes, Specific Aim 2 - Train and position for success the next generation of clinical and translational scientists, and Specific Aim 3 - Actively engage multiple stakeholders, including rural communities, in research and effectively disseminate research results to rural populations in a manner that facilitates understanding and trust. There are 3 important cross-cutting themes around which our efforts will be focused that include: 1) Rural Health, 2) Diversity, Equity, and Inclusion (engaging not only WV’s rural communities but also WV’s communities of color; equally important is supporting diverse investigators), and 3) the clinician scientists of tomorrow – able to frame the right questions and work to find the answers. Central to attainment of our specific aims is the highly collaborative statewide organization that WVCTSI has developed over the preceding 9 years and that now includes every major healthcare organization and academic medical center in WV, the state health department (WVDHHR), the National Institute for Occupational Safety and Health, and >100 primary care organizations across WV that constitute the WV Practice-Based Research Network. Equally important is the high level of collaboration and commitment among WVCTSI’s cores. Successful completion of our objectives will inform policy, practice, and community changes resulting in improved WV health outcomes.

西弗吉尼亚州是唯一一个完全位于阿巴拉契亚地区的州，它的预期寿命是世界上最低的 在许多慢性病类别中排名垫底或接近垫底。WV临床和 翻译科学研究所(WVCTSI)成立于2012年，通过最初的机构 临床和转化研究发展奖(IDEA-CTR)，并于#年成功续展 2017年。在过去的9年里，WVCTSI培育和培育了一个高度协作的、全州范围的 研究基础设施，以解决西弗吉尼亚州巨大的健康差距。在过去的4年里， WVCTSI的生产力非常高，有1,325份出版物，951份资金申请和688份 外部资金奖励总额为159.3美元。世界志愿人员方案下一次筹资的首要目标 Cycle将成为一股变革力量，引领全州的临床和转化性协作 对西弗吉尼亚州健康结果产生积极影响的研究。我们将通过以下几个方面实现这一目标 具体目标：具体目标1-在全球范围内建立协作、富有成效的研究基础设施 对改善世界卫生组织的健康成果做出实质性贡献，具体目标2-培训和定位 下一代临床和转化型科学家的成功，以及具体目标3--积极参与 包括农村社区在内的多个利益攸关方参与研究并有效传播研究 以促进理解和信任的方式将成果带给农村人口。有三个重要的因素 我们将重点关注的交叉主题包括：1)农村卫生，2)多样性， 公平和包容(不仅让西弗吉尼亚的农村社区参与，也让西弗吉尼亚的有色人种社区参与； 同样重要的是支持不同的研究人员)，以及3)未来的临床医生科学家 提出正确的问题，并努力找到答案。对实现我们的具体目标至关重要 是WVCTSI在之前的9年中开发的高度协作的全州组织 这包括西弗吉尼亚州的每一家主要医疗机构和学术医疗中心， 国家卫生部门(WVDHHR)，国家职业安全与健康研究所，以及 &gt；100个西弗吉尼亚州的初级保健组织，构成了西弗吉尼亚州以实践为基础的研究网络。 同样重要的是WVCTSI核心之间的高度合作和承诺。 成功完成我们的目标将为政策、实践和由此产生的社区变化提供信息 在改善世界卫生组织的健康结果方面。

项目成果

Aerosol physicochemical determinants of carbon black and ozone inhalation co-exposure induced pulmonary toxicity.

• DOI: 10.1093/toxsci/kfac113
• 发表时间: 2023-01-31
• 期刊: Toxicological sciences : an official journal of the Society of Toxicology

The surgical management of complicated peptic ulcer disease: An EAST video presentation.

• DOI: 10.1097/ta.0000000000003636
• 发表时间: 2022-07-01
• 期刊: The journal of trauma and acute care surgery

Poor Response to Checkpoint Immunotherapy in Uveal Melanoma Highlights the Persistent Need for Innovative Regional Therapy Approaches to Manage Liver Metastases.

• DOI: 10.3390/cancers13143426
• 发表时间: 2021-07-08
• 期刊: Cancers
• 影响因子: 5.2
• 作者: Szeligo BM;Ivey AD;Boone BA
• 通讯作者: Boone BA

A rare case of gliomatosis cerebri lurking beneath the shadows of a stroke mimic.

• DOI: 10.1016/j.radcr.2021.06.060
• 发表时间: 2021-09
• 期刊: Radiology case reports
• 作者: Prasad A;Hurlburt G;Van Antwerp E;Srivastava S;Sriwastava S
• 通讯作者: Sriwastava S

Community risks for SARS-CoV-2 infection among fully vaccinated US adults by rurality: A retrospective cohort study from the National COVID Cohort Collaborative.

• DOI: 10.1371/journal.pone.0279968
• 发表时间: 2023
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Anzalone, Alfred Jerrod;Sun, Jing;Vinson, Amanda J.;Beasley, William H.;Hillegass, William B.;Murray, Kimberly;Hendricks, Brian M.;Haendel, Melissa;Geary, Carol Reynolds;Bailey, Kristina L.;Hanson, Corrine K.;Miele, Lucio;Horswell, Ronald;McMurry, Julie A.;Porterfield, J. Zachary;Vest, Michael T.;Bunnell, H. Timothy;Harper, Jeremy R.;Price, Bradley S.;Santangelo, Susan L.;Rosen, Clifford J.;McClay, James C.;Hodder, Sally L.
• 通讯作者: Hodder, Sally L.