Administrative Supplement for Gulf Coast Center for Precision Environmental Health

墨西哥湾沿岸精准环境健康中心行政补充

• 批准号: 10436634
• 负责人: Cornelis Johan Elferink
• 金额: $ 120.34万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10436634
• 关键词: Address; Administrative Supplement; Adult; Age-Months; Animals; Area; Automobile Driving; Biological Markers; Blood; Brain; ChIP-seq; Chemicals; Communication; Communities; Control Groups; Core Facility; Country; Data; Development; Disasters; Discipline; Disease; Enhancers; Environment; Environmental Exposure; Environmental Health; Epigenetic Process; Exhibits; Exposure to; Faculty; Female; Fostering; Funding; Gases; Gene Expression; Gene Expression Profile; Gene Expression Profiling; Genetic; Genetic Transcription; Genomics; Goals; Grant; Health; Health Policy; Histones; Home; Human; Individual; Industry; Infrastructure; Institution; Intervention; Leadership; Life; Link; Medical center; Mentors; Modification; Mus; National Institute of Environmental Health Sciences; Neurocognitive; Oils; Outcome; Pattern; Phenotype; Pilot Projects; Plants; Process; Promoter Regions; Research; Research Activity; Research Personnel; Research Support; Resources; Risk; Seasons; Site; Technology; Testing; Tetrachlorodibenzodioxin; Texas; Time; Tissues; Toxicant exposure; Training Programs; Translational Research; Translations; Walkers; base; career development; catalyst; community engagement; design; early life exposure; epigenome; epigenomics; experience; fine particles; genome-wide; gulf coast; health science research; histone modification; improved; inter-institutional; male; member; next generation; programs; promoter; ranpirnase; research and development; response; sex; skills; superfund site; transcriptome; transcriptome sequencing; transcriptomics

ABSTRACT: OVERALL The Houston-Galveston area is home to over a dozen Superfund sites, and is a hub for the petrochemical industry with 500 chemical plants, 10 refineries and >6000 miles of oil, gas and chemical pipelines in what has become the country’s largest energy corridor. The area is also home to the largest medical center in the world, the Texas Medical Center. Thus, both the need, and size of the opportunity, for an NIEHS Environmental Health Sciences (EHS) Core Center (EHS-CC) in this region is great. As the EHS-CC for the Texas Medical Center, the Gulf Coast Center for Precision Environmental Health (GC-CPEH) will be the focal point and catalyst for impactful EHS research, multi-directional communication with local communities and stakeholders, and the engine driving translation of precision environmental health research advances to improve human health. The Goals for the GC-CPEH are to 1: Integrate and catalyze impactful EHS research across disciplines and institutions of the Texas Medical Center, and promote the next-generation of EHS researchers; 2: Provide inter- institutional access to resources and cutting-edge technologies to accelerate translation, and reverse translation, of research advances to improve human environmental health; 3: Support and empower community engagement across the Gulf Coast region by linking community stakeholders and investigators in multi-directional communication activities that inform GC-CPEH research; 4: Enable rapid response research activities during and after environmental disasters in the Gulf Coast region. The GC-CPEH has 34 Full members, 17 of whom have active NIEHS-funded grant support with an annual direct funding base >$5 million. The Center will support precision environmental health research through its Thematic Focus Areas: Early Life Genetic and Epigenetic Environment Interactions; Mechanisms and Interventions in Human Environmental Disease; and Disaster Research Response. The GC-CPEH will also promote research through its Pilot Project Program, accelerate research advances with seamless access to Next-gen technologies via the PIPELINE Facility Core and an IHSFC that will promote translational research; activities facilitated by Navigators and the Matching Funds Core Utilization Program. The Administrative Core, composed of highly seasoned EHS leaders, provides organizational infrastructure, and mentoring for junior faculty that includes a Career Development Leaders-in-Training program to promote development of research and professional leadership skills. An experienced and vibrant CEC will foster multi-directional communication with communities and stakeholders, and inform environmental health policy for the Gulf Coast Region.

摘要：总体 休斯顿-加尔维斯顿地区拥有十多个超级基金站点，并且是石化行业的中心 工业，拥有 500 家化工厂、10 家炼油厂和超过 6000 英里的石油、天然气和化学品管道 成为全国最大的能源走廊。该地区还拥有世界上最大的医疗中心， 德克萨斯医疗中心。因此，NIEHS 环境健康的需求和机会的大小 这个地区的科学（EHS）核心中心（EHS-CC）很棒。作为德克萨斯医疗中心的 EHS-CC， 墨西哥湾沿岸精准环境健康中心 (GC-CPEH) 将成为焦点和催化剂 有影响力的 EHS 研究、与当地社区和利益相关者的多向沟通以及 推动精准环境健康研究进展转化的引擎，改善人类健康。这 GC-CPEH 的目标是 1：整合并促进跨学科和有影响力的 EHS 研究 德克萨斯医学中心的机构，并促进下一代 EHS 研究人员； 2：提供间 机构获取资源和尖端技术以加速转化和逆转 翻译研究进展以改善人类环境健康； 3：支持和授权 通过将社区利益相关者和调查人员联系起来，整个墨西哥湾沿岸地区的社区参与 为 GC-CPEH 研究提供信息的多向沟通活动； 4：实现快速响应研究 墨西哥湾沿岸地区环境灾害期间和之后的活动。 GC-CPEH 有 34 个完整的 成员，其中 17 人获得 NIEHS 资助的积极赠款支持，年度直接资助基础超过 500 万美元。 该中心将通过其主题重点领域支持精确的环境健康研究：早期生活 遗传和表观遗传环境相互作用；人类环境的机制和干预措施 疾病;和灾难研究响应。 GC-CPEH 还将通过其试点项目促进研究 通过管道无缝访问下一代技术，加速研究进展 核心设施和 IHSFC 将促进转化研究；导航员和 配套资金核心利用计划。行政核心由经验丰富的 EHS 组成 领导者，提供组织基础设施，并为初级教师提供指导，包括职业生涯 发展领导者培训计划，以促进研究和专业领导力的发展 技能。经验丰富、充满活力的 CEC 将促进与社区和社区的多向沟通 利益相关者，并为墨西哥湾沿岸地区的环境健康政策提供信息。