Gulf Coast Center for Precision Environmental Health

墨西哥湾沿岸精准环境健康中心

• 批准号: 10647883
• 负责人: Cornelis Johan Elferink
• 金额: $ 157.2万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10647883
• 关键词: Acceleration; Area; Automobile Driving; Awareness; Back; Biological Specimen Banks; Chemicals; Communication; Communities; Core Facility; Country; Data Science; Development; Disasters; Discipline; Disease; Educational workshop; Emergency Situation; Emerging Technologies; Environment; Environmental Health; Environmental Science; Epigenetic Process; Faculty; Fees; Floods; Fostering; Funding; Gases; Genetic; Goals; Grant; Health; Health Policy; Health Sciences; Health Services Accessibility; Home; Human; Hurricane; Individual; Industry; Infrastructure; Institution; Institutional Review Boards; Intervention; Investigation; Leadership; Life; Link; Medical center; Mentors; National Institute of Environmental Health Sciences; Oils; Pilot Projects; Plants; Play; Policy Making; Population; Protocols documentation; Questionnaires; Research; Research Activity; Research Personnel; Resources; Role; Seasons; Services; Structure; Technology; Texas; Training; Training Programs; Translating; Translational Research; Translations; Vision; base; career development; catalyst; community engagement; disorder risk; empowerment; experience; gulf coast; health science research; high risk; improved; instrumentation; inter-institutional; man-made disasters; member; multidisciplinary; next generation; preference; programs; research and development; response; skills; superfund site

ABSTRACT: OVERALL The Houston-Galveston area is home to over a dozen Superfund sites, and is a hub for the petrochemical industry with 500 chemical plants, 10 refineries and >6000 miles of oil, gas and chemical pipelines in what has become the country’s largest energy corridor. The area is also home to the largest medical center in the world, the Texas Medical Center. Thus, both the need, and size of the opportunity, for an NIEHS Environmental Health Sciences (EHS) Core Center (EHS-CC) in this region is great. As the EHS-CC for the Texas Medical Center, the Gulf Coast Center for Precision Environmental Health (GC-CPEH) will be the focal point and catalyst for impactful EHS research, multi-directional communication with local communities and stakeholders, and the engine driving translation of precision environmental health research advances to improve human health. The Goals for the GC-CPEH are to 1: Integrate and catalyze impactful EHS research across disciplines and institutions of the Texas Medical Center, and promote the next-generation of EHS researchers; 2: Provide inter- institutional access to resources and cutting-edge technologies to accelerate translation, and reverse translation, of research advances to improve human environmental health; 3: Support and empower community engagement across the Gulf Coast region by linking community stakeholders and investigators in multi-directional communication activities that inform GC-CPEH research; 4: Enable rapid response research activities during and after environmental disasters in the Gulf Coast region. The GC-CPEH has 34 Full members, 17 of whom have active NIEHS-funded grant support with an annual direct funding base >$5 million. The Center will support precision environmental health research through its Thematic Focus Areas: Early Life Genetic and Epigenetic Environment Interactions; Mechanisms and Interventions in Human Environmental Disease; and Disaster Research Response. The GC-CPEH will also promote research through its Pilot Project Program, accelerate research advances with seamless access to Next-gen technologies via the PIPELINE Facility Core and an IHSFC that will promote translational research; activities facilitated by Navigators and the Matching Funds Core Utilization Program. The Administrative Core, composed of highly seasoned EHS leaders, provides organizational infrastructure, and mentoring for junior faculty that includes a Career Development Leaders-in-Training program to promote development of research and professional leadership skills. An experienced and vibrant CEC will foster multi-directional communication with communities and stakeholders, and inform environmental health policy for the Gulf Coast Region.

摘要：总体 休斯顿-加尔维斯顿地区是十几个超级基金的所在地，也是石油化工的中心。 该行业拥有500家化工厂，10家炼油厂和超过6000英里的石油，天然气和化学品管道， 成为我国最大的能源走廊。该地区也是世界上最大的医疗中心的所在地， 德州医疗中心因此，无论是需要，和机会的大小，为NIEHS环境健康 科学（EHS）核心中心（EHS-CC）在这个地区是伟大的。作为德克萨斯医疗中心的EHS-CC， 墨西哥湾沿岸精密环境卫生中心（GC-CPEH）将成为以下方面的协调中心和催化剂： 有影响力的EHS研究，与当地社区和利益相关者的多方位沟通， 发动机驱动翻译的精确环境健康研究进展，以改善人类健康。的 GC-CPEH的目标是1：整合和促进跨学科的有影响力的EHS研究， 德州医疗中心的机构，并促进下一代的EHS研究人员; 2：提供跨 机构获得资源和尖端技术，以加速翻译， 翻译，研究进展，以改善人类环境健康; 3：支持和授权 通过将社区利益相关者和调查人员联系起来， 为GC-CPEH研究提供信息的多方向交流活动; 4：实现快速反应研究 在墨西哥湾沿岸地区发生环境灾害期间和之后的活动。GC-CPEH有34个完整的 成员，其中17人有积极的NIEHS资助的赠款支持，每年直接资助基础> 500万美元。 该中心将通过其主题重点领域支持精确的环境健康研究：早期生命 遗传和表观遗传环境的相互作用;人类环境中的机制和干预 疾病;和灾害研究响应。GC-CPEH还将通过其试点项目促进研究 计划，通过管道无缝访问下一代技术，加速研究进展 设施核心和IHSFC，将促进转化研究;活动由导航员和 匹配基金核心利用方案。管理核心，由经验丰富的EHS组成 领导者，提供组织基础设施，并指导初级教师，包括职业生涯 发展领导者培训计划，以促进研究和专业领导能力的发展 skills.一个经验丰富和充满活力的CEC将促进与社区的多方位沟通， 利益相关者，并为墨西哥湾沿岸地区的环境卫生政策提供信息。

项目成果

Multiomic Investigations into Lung Health and Disease.

• DOI: 10.3390/microorganisms11082116
• 发表时间: 2023-08-19
• 期刊: Microorganisms
• 影响因子: 4.5

Under-recognition of medically unexplained symptom conditions among US Veterans with Gulf War Illness.

• DOI: 10.1371/journal.pone.0259341
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kane NS;Anastasides N;Litke DR;Helmer DA;Hunt SC;Quigley KS;Pigeon WR;McAndrew LM
• 通讯作者: McAndrew LM

ROLE OF CYTOCHROME P450S IN THE GENERATION AND METABOLISM OF REACTIVE OXYGEN SPECIES.

• DOI: 10.1016/j.cotox.2017.10.003
• 发表时间: 2018-03
• 期刊: Current opinion in toxicology
• 影响因子: 4.6
• 作者: Veith A;Moorthy B
• 通讯作者: Moorthy B

CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression.

• DOI: 10.1136/jmedgenet-2020-106987
• 发表时间: 2021-07
• 期刊: Journal of medical genetics
• 影响因子: 4
• 作者: Cao X;Wolf A;Kim SE;Cabrera RM;Wlodarczyk BJ;Zhu H;Parker M;Lin Y;Steele JW;Han X;Ramaekers VT;Steinfeld R;Finnell RH;Lei Y
• 通讯作者: Lei Y

Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Children in Jamaica.

• DOI: 10.3390/ijerph19010466
• 发表时间: 2022-01-01
• 期刊: International journal of environmental research and public health
• 作者: Rahbar MH;Samms-Vaughan M;Zhao Y;Saroukhani S;Zaman SF;Bressler J;Hessabi M;Grove ML;Shakspeare-Pellington S;Loveland KA
• 通讯作者: Loveland KA