Assessment of Policies through Prediction of Long-term Effects on Cardiovascular Disease Using Simulation (APPLE CDS)

通过模拟预测对心血管疾病的长期影响来评估政策（APPLE CDS）

• 批准号: 10436403
• 负责人: Yan Li
• 金额: $ 16.87万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10436403
• 关键词: Adopted; Adult; Behavior; Blood Pressure; Body mass index; Cardiovascular Diseases; Cities; Communities; Complex; Computer Simulation; Consumption; Coronary heart disease; Cost Savings; Cost of Illness; Data; Decision Making; Diabetes Mellitus; Disease Outcome; Eating; Ensure; Food; Food Policy; Geographic Locations; Goals; Government; Health; Health Care Costs; Health Planning; Health Status; Health behavior; Health behavior outcomes; Hypertension; Intervention; Investigation; Link; Local Government; Long-Term Effects; Mental Health; Modeling; Morbidity - disease rate; Neighborhoods; New York City; Outcome; Pathway interactions; Policies; Population; Population Characteristics; Public Health; Quality-Adjusted Life Years; Recommendation; Research; Research Project Grants; Resources; Restaurants; Risk Factors; Sodium; Stroke; System; Techniques; Unhealthy Diet; United States; Vendor; base; cardiometabolism; cardiovascular disorder prevention; cardiovascular health; community organizations; comparative effectiveness; contextual factors; cost effective; design; dietary; disability; discount; evidence base; experience; fast food; fruits and vegetables; health data; health economics; improved; income disparities; innovation; insight; model development; models and simulation; modifiable risk; mortality; novel; nutrition; population health; programs; public health research; simulation; success; warning label

Project Summary/Abstract Dietary behaviors are key modifiable risk factors in averting cardiovascular disease (CVD), the leading cause of morbidity, mortality, and disability in the United States (US). Despite national and local initiatives to promote healthy dietary behaviors, unhealthy diets remain a difficult, perplexing population health problem requiring initiatives and solutions at the community and population levels. Prior to investing in implementation, health practitioners and policymakers—often working with limited resources—need to compare the population health impact of different food policies and programs to then determine priorities. The goal of this project, Assessment of Policies through Prediction of Long-term Effects on Cardiovascular Disease Using Simulation (APPLE CDS), is to compare the effects of food policies and programs on CVD-related outcomes and health care costs for adults. This will be useful to aid local government and community organizations in priority setting and decision-making. Policy and program assessment will be conducted using agent-based modeling, an efficient, novel technique that has been underutilized in public health research. We assembled a team of experts in CVD, nutrition, public health, health economics, and computer simulation modeling who are committed to working together to identify realistic pathways that can be used to improve dietary behaviors. The Specific Aims are to: (1) develop an agent-based model to assess and compare the impact of alternative food policies and programs on dietary behaviors, blood pressure, body mass index (BMI), and diabetes across different neighborhoods in NYC and (2) link the agent-based model with the well-established, validated NYC CVD Policy Model to project the long-term impact of different food policies and programs on cardiovascular disease outcomes (e.g., hypertension, coronary heart disease, stroke), quality-adjusted life years (QALYs), and health care costs. We will leverage the rich community-level health data on dietary behaviors collected by the NYC Department of Health and Mental Hygiene (DOHMH) to parameterize and validate the model. In addition, our close partnerships with the NYC DOHMH and a broad range of community-based organizations across the city will ensure that simulation results will be used to select and optimize implementation of the most cost-effective, neighborhood-specific food policies and programs to improve population health. Finally, the NYC experience can serve as an example by which other local health departments and community-based organizations may make more informed decisions for their own priority setting and program implementation.

项目概要/摘要 饮食行为是预防心血管疾病（CVD）的关键可改变危险因素，心血管疾病是主要原因 美国 (US) 的发病率、死亡率和残疾情况。尽管国家和地方采取措施促进 健康的饮食行为，不健康的饮食仍然是一个困难的、令人困惑的人口健康问题，需要 社区和人口层面的倡议和解决方案。在投资实施之前，卫生 从业者和政策制定者通常资源有限，需要比较人口健康状况 不同粮食政策和计划的影响，然后确定优先事项。这个项目的目标， 通过预测对心血管疾病的长期影响来评估政策 模拟 (APPLE CDS)，用于比较食品政策和计划对 CVD 相关结果的影响 以及成人的医疗保健费用。这将有助于帮助当地政府和社区组织 优先事项设定和决策。政策和计划评估将使用基于代理的方式进行 建模是一种高效的新技术，但在公共卫生研究中尚未得到充分利用。我们组装了一个 由心血管疾病、营养、公共卫生、卫生经济学和计算机模拟建模领域的专家组成的团队 致力于共同努力找出可用于改善饮食行为的现实途径。这 具体目标是：(1) 开发基于代理的模型来评估和比较替代食品的影响 有关饮食行为、血压、体重指数 (BMI) 和糖尿病的政策和计划 纽约市的不同社区，以及 (2) 将基于代理的模型与成熟且经过验证的纽约市联系起来 心血管疾病政策模型，用于预测不同食品政策和计划对心血管的长期影响 疾病结果（例如高血压、冠心病、中风）、质量调整生命年 (QALY)、 和医疗保健费用。我们将利用收集的丰富的社区级饮食行为健康数据 纽约市健康和心理卫生局 (DOHMH) 对模型进行参数化和验证。在 此外，我们与 NYC DOHMH 和广泛的社区组织建立了密切的合作关系 全市范围内将确保模拟结果将用于选择和优化最优化的实施方案 具有成本效益、针对具体社区的粮食政策和计划，以改善人口健康。最后， 纽约市的经验可以作为其他地方卫生部门和社区的榜样 各组织可以为自己的优先事项设定和计划实施做出更明智的决定。

项目成果

Medical financial hardship between young adult cancer survivors and matched individuals without cancer in the United States.

美国年轻的癌症幸存者和匹配的未患癌症的人之间的医疗经济困难。

• DOI: 10.1093/jncics/pkae007
• 发表时间: 2024
• 期刊: JNCI cancer spectrum
• 影响因子: 4.4
• 作者: Li,Lihua;Zhang,Donglan;Li,Yan;Jain,Mayuri;Lin,Xingyu;Hu,Rebecca;Liu,Junxiu;Thapa,Janani;Mu,Lan;Chen,Zhuo;Liu,Bian;Pagán,JoséA
• 通讯作者: Pagán,JoséA

Assessing the Health and Economic Impact of a Potential Menthol Cigarette Ban in New York City: a Modeling Study.

评估纽约市潜在薄荷香烟禁令对健康和经济的影响：一项建模研究。

• DOI: 10.1007/s11524-021-00581-8
• 发表时间: 2021-12
• 期刊: Journal of urban health : bulletin of the New York Academy of Medicine
• 作者: Li Y;Sisti J;Flórez KR;Albrecht SS;Viswanath A;Davila M;Cantrell J;Brahmbhatt D;Thompson AB;Jasek J;Chambers EC
• 通讯作者: Chambers EC

Consumption of Ultraprocessed Foods and Body Fat Distribution Among U.S. Adults.

美国成年人超加工食品的消费和体脂肪分布。

• DOI: 10.1016/j.amepre.2023.03.012
• 发表时间: 2023
• 期刊: American journal of preventive medicine
• 影响因子: 5.5
• 作者: Liu,Junxiu;Steele,EurídiceMartinez;Li,Yan;Yi,StellaS;Monteiro,CarlosA;Mozaffarian,Dariush
• 通讯作者: Mozaffarian,Dariush

Economic Evaluation of Prenatal and Postpartum Care in Women With Gestational Diabetes and Hypertensive Disorders of Pregnancy: A Systematic Review.

• DOI: 10.1016/j.jval.2022.07.014
• 发表时间: 2022-12
• 期刊: VALUE IN HEALTH
• 影响因子: 4.5
• 作者: Li, Weixin;Kim, Chi-Son;Howell, Elizabeth A.;Janevic, Teresa;Liu, Bian;Shi, Lizheng;Li, Yan
• 通讯作者: Li, Yan

Consumption of Ultraprocessed Foods and Diet Quality Among U.S. Children and Adults.

• DOI: 10.1016/j.amepre.2021.08.014
• 发表时间: 2022-03
• 期刊: AMERICAN JOURNAL OF PREVENTIVE MEDICINE
• 影响因子: 5.5
• 作者: Liu, Junxiu;Steele, Euridice Martinez;Li, Yan;Karageorgou, Dimitra;Micha, Renata;Monteiro, Carlos A.;Mozaffarian, Dariush
• 通讯作者: Mozaffarian, Dariush