Simultaneous multi-slice GABA-edited MRSI in the developing brain

发育中大脑的同步多切片 GABA 编辑 MRSI

• 批准号: 9372604
• 负责人: Yan Li
• 金额: $ 23.78万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9372604
• 关键词: 37 weeks gestation; Adult; Affect; Age; Aminobutyric Acids; Anatomy; Area; Biochemical; Birth trauma; Brain; Brain Diseases; Brain Injuries; Brain region; Breathing; Centers for Disease Control and Prevention (U.S.); Cerebral Palsy; Child; Clinical; Clinical assessments; Cognition; Communities; Congenital Abnormality; Data; Detection; Development; Diagnosis; Diffusion; Disease; Environment; Evaluation; Face; Family; Functional Imaging; Glutamates; Glutamine; Goals; Health; Healthcare; Image; Inborn Errors of Metabolism; Infant; Learning; Life; Location; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mediator of activation protein; Metabolic; Methodology; Methods; Neurologic; Neurotransmitters; Newborn Infant; Outcome; Outcome Measure; Patients; Phase; Physiologic pulse; Population; Pregnancy; Premature Infant; Property; Recruitment Activity; Reproducibility; Research; Resolution; Rest; Risk; Role; Scanning; Shapes; Signal Transduction; Slice; Spectrum Analysis; Techniques; Technology; Testing; Therapeutic Intervention; Time; Treatment Efficacy; Visit; anatomic imaging; base; brain metabolism; clinically relevant; cognitive development; data acquisition; design; disability; economic cost; emotional distress; feeding; follow-up; gamma-Aminobutyric Acid; healthy volunteer; high risk; improved; improved outcome; in vivo; interest; metabolic imaging; metabolic profile; nervous system disorder; neurodevelopment; novel; patient population; premature; receptor; reconstruction; spectroscopic imaging; symposium; treatment strategy; volunteer

Project Summary Metabolic imaging in newborns has proven useful for clinical assessment of children with brain injuries, extrinsic and inborn errors of metabolism, and disorders of brain maturation. As the brain matures, the metabolic profiles also change. Υ-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mature brain, is an excitatory mediator during early brain development, and showed difference between preterm and term infants. Single voxel spectroscopic (SVS) acquisition is the most commonly available methodology for non-invasively investigating brain metabolism but covering multiple anatomical regions is challenging because each of the acquisitions takes approximately 5 minutes. In this proposed project, we will leverage the most recent advances in multi-channel phased arrays with RF technology to develop multi-slice GABA-edited 2D MR spectroscopy imaging (MRSI) with high spatial resolution that is acquired simultaneously at multiple locations in under 5 minutes of scan time. Metabolite accuracy compared to standard SVS and test- retest reliability will be conducted on scans from 10 healthy adult volunteers with one week apart. We will recruit 30 preterm patients. They will undergo their imaging exams when they are clinically stable and before discharge, and will return for follow-up visits at the 6-month corrected age. Metabolic profiles, along with the convention and advanced MR imaging parameters, will be correlated to the clinical outcome measures. The fast MRSI data acquisition being developed will provide capabilities for evaluating preterm infants and will also be important for diagnosis and assessment of a much broader range of neurological diseases. According to CDC, there are more than 500,000 babies in the US each year that are born prematurely (less than 37 weeks gestation). Babies born between 24 and 31 weeks gestation are five times as likely as full-term infants to have a birth defect, and infants born even a few weeks early are three times higher. Those who survive face the risk of life long health consequences, including difficulties in breathing and feeding, cerebral palsy, and problems in learning. Developing criteria of evaluating and identifying temporal and spatial changes in metabolites are critical for evaluating brain development in preterm infants. The proposed simultaneous multi-slice MRSI acquisition will enable assessment of a wider area of the brain within a clinical feasible time, allow longitudinal detection of the metabolic profiles in the same locations after voxel shift, and provide averaged spectra in irregular shapes, which will improve patient evaluation. The targeted patient population of newborns would benefit immediately from the increased mapping of metabolic information, while maintaining scan time, minimizing the time spent outside of NICU and reducing potential risk.

项目摘要 新生儿的代谢成像已被证明对脑损伤儿童的临床评估有用， 新陈代谢的外源性和先天错误，以及大脑成熟障碍。随着大脑的成熟， 新陈代谢特征也会发生变化。Υ-氨基丁酸是人体内主要的抑制性神经递质。 成熟的大脑，是大脑发育早期的兴奋性介质，并显示出不同 早产儿和足月儿。单体素光谱(SVS)采集是最常用的 非侵入性研究脑代谢但覆盖多个解剖区域的方法学是 具有挑战性，因为每一次收购都需要大约5分钟。在这个拟议的项目中，我们将 利用多通道相控阵的最新进展和射频技术开发多切片 同时采集的具有高空间分辨率的GABA编辑的2D磁共振波谱成像(MRSI) 在不到5分钟的扫描时间内在多个位置进行扫描。代谢物准确度与标准SVS和测试- 重测可靠性将对10名健康的成年志愿者进行，扫描间隔一周。我们会 招募30名早产患者。他们将在临床稳定后及之前接受影像检查。 出院，并将在6个月矫正年龄时回来进行随访。代谢特征，以及 常规和先进的磁共振成像参数将与临床结果相关。这个 正在开发的快速磁共振成像数据采集将提供评估早产儿的能力，并将 对于诊断和评估范围更广的神经疾病非常重要。 根据美国疾病控制与预防中心的数据，美国每年有超过50万名早产婴儿(更少 怀孕37周以上)。怀孕24周至31周的婴儿出生的几率是足月的五倍 婴儿有出生缺陷，即使是提前几周出生的婴儿也要高出三倍。那些 生存面临终身健康后果的风险，包括呼吸和喂养困难，脑部 瘫痪，以及学习上的问题。制定评估和识别时间和空间变化的标准 代谢产物是评估早产儿大脑发育的关键。建议的同步 多层MRSI采集将能够在临床可行的时间内评估更广泛的大脑区域， 允许在体素移动后对相同位置的代谢概况进行纵向检测，并提供 不规则形状的平均频谱，这将改善患者的评估。的目标患者群体 新生儿将立即受益于代谢信息图谱的增加，同时保持 扫描时间，最大限度地减少在NICU外花费的时间，并降低潜在风险。