Development of osmoregulation disruptors for tick control

开发用于蜱控制的渗透调节干扰剂

基本信息

  • 批准号:
    10432104
  • 负责人:
  • 金额:
    $ 22.8万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-06-16 至 2023-05-31
  • 项目状态:
    已结题

项目摘要

Project Summary Ticks are obligatory ectoparasites that feed on vertebrates and transmit pathogens during blood feeding, causing health problems globally in animals and humans. Ticks transmit a wide variety of pathogens, including bacteria (e.g., rickettsia), protozoa, and viruses, and directly damage their hosts. A most significant tick physiology that allows ticks survive in the field is maintaining water balance throughout the lifetime including the off-host periods. The osmoregulatory mechanisms in Metastriata ticks include: 1) directly drinking water through the gut and the salivary glands, 2) losing large amounts of water through dermal secretion, and 3) losing water with excretion of metabolic wastes. The central dogma in this proposal is using the tick water drinking behavior as a route of delivering toxic agents to disrupt the osmoregulatory pathway, which is a vulnerable toxicological target in off-host ticks. Ample preliminary data provides the proof of the concept. Tick deaths could be induced by voluntary drinking of phosphate-rich iso-osmotic solutions and also by thermally induced exhaustive dermal secretion. The aims of the proposals are to develop the tick- specific osmoregulation disruptor (Aim 1) and to investigate the physiology of water loss through tick dermal secretion (Aim 2). In the Aim 1, we will study the physiology of the inorganic phosphate metabolism and phosphate-mediated electrochemical imbalance in the excretory system, which function as a significant osmoregulatory disruptor. Aim2 will uncover the mechanisms of dermal secretion including serotonin-mediated regulation and ion transport mechanisms in the dermal glands, which is a unique organ associated with a loss of large amount (~300 nL) of fluid within a second upon thermal/mechanical stimulation. The strategy using an osmoregulatory disruptor fits well in the hot and dry season in the Midwest and Southwest area of the U.S. where numerous Metastriata ticks, Amblyomma, Dermacentor, Rhipicephalus, and Haemaphysalis, and the pathogen transmission have been reported. The current proposal is to expand the knowledge of the target physiology, linking to the long-term goal in the development of environmentally compatible tick control measures.
项目摘要 蜱是专性体外寄生虫,以脊椎动物为食,并在吸血过程中传播病原体, 全球范围内的动物和人类健康问题。蜱传播各种各样的病原体,包括细菌(例如, 立克次氏体)、原生动物和病毒,并直接损害其宿主。一种最重要的蜱虫生理学允许蜱虫 在野外生存的关键是在整个生命周期中保持水平衡,包括非宿主时期。的 Metastriata蜱的饮水调节机制包括:1)通过肠道和唾液直接饮水 腺体,2)通过皮肤分泌失去大量的水,和3)随着代谢废物的排泄而失去水。 该提案的中心法则是利用蜱虫饮水行为作为将有毒物质传递给 破坏蜱虫的调节途径,这是一个脆弱的毒理学目标,在离开宿主蜱。充足的初步 数据为这一概念提供了证据。蜱虫死亡可以通过自愿饮用富含磷酸盐的等渗 溶液以及热诱导的耗尽性真皮分泌。这些建议的目的是发展蜱虫- 特异性呼吸调节干扰物(Aim 1),并研究蜱真皮分泌物失水的生理学 (Aim 2)。在本研究中,我们将研究无机磷代谢的生理和磷介导的 排泄系统中的电化学不平衡,其作为重要的排泄调节干扰物起作用。aim 2将 揭示真皮分泌的机制,包括降钙素介导的调节和离子转运机制, 真皮腺,这是一种独特的器官,在一秒钟内会损失大量(约300 nL)液体, 热/机械刺激。使用一个可调节的干扰物的策略非常适合在炎热和干燥的季节, 美国的中西部和西南部地区,有大量的转移条纹蜱、钝眼蜱、革蜱、扇头蜱, 和血蜱,并有病原体传播的报道。目前的建议是扩大知识 目标生理学,与开发环境相容的蜱虫控制的长期目标相联系 措施

项目成果

期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Characterization of Iflavirus in the Red Flour Beetle, Tribolium castaneum (Coleoptera; Tenebrionidae).
  • DOI:
    10.3390/insects14030220
  • 发表时间:
    2023-02-23
  • 期刊:
  • 影响因子:
    3
  • 作者:
    Fatehi S;Aikins M;Philips TW;Brown S;Zhu KY;Scully ED;Park Y
  • 通讯作者:
    Park Y
Bee-safe peptidomimetic acaricides achieved by comparative genomics.
  • DOI:
    10.1038/s41598-022-20110-0
  • 发表时间:
    2022-10-14
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Jindal, Vikas;Li, Daqi;Rault, Leslie C.;Fatehi, Soheila;Singh, Rupinder;Mating, Moritz;Zou, Ye;Ng, Ho-Leung;Kaczmarek, Krzysztof;Zabrocki, Janusz;Gui, Shunhua;Smagghe, Guy;Anderson, Troy D.;Nachman, Ronald J.;Park, Yoonseong
  • 通讯作者:
    Park, Yoonseong
Water absorption through salivary gland type I acini in the blacklegged tick, Ixodes scapularis.
  • DOI:
    10.7717/peerj.3984
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Kim D;Maldonado-Ruiz P;Zurek L;Park Y
  • 通讯作者:
    Park Y
The bacterial community of the lone star tick (Amblyomma americanum).
  • DOI:
    10.1186/s13071-020-04550-z
  • 发表时间:
    2021-01-14
  • 期刊:
  • 影响因子:
    3.2
  • 作者:
    Maldonado-Ruiz LP;Neupane S;Park Y;Zurek L
  • 通讯作者:
    Zurek L
Diversity of the Bacterial and Viral Communities in the Tropical Horse Tick, Dermacentor nitens, in Colombia.
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Yoonseong Park其他文献

Yoonseong Park的其他文献

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{{ truncateString('Yoonseong Park', 18)}}的其他基金

Development of osmoregulation disruptors for tick control
开发用于蜱控制的渗透调节干扰剂
  • 批准号:
    10284772
  • 财政年份:
    2021
  • 资助金额:
    $ 22.8万
  • 项目类别:
Discovery of GPCR-targeted insecticides for malaria mosquito control
发现用于控制疟疾蚊子的 GPCR 靶向杀虫剂
  • 批准号:
    9435634
  • 财政年份:
    2017
  • 资助金额:
    $ 22.8万
  • 项目类别:
Signaling pathways for tick salivary secretion
蜱唾液分泌的信号通路
  • 批准号:
    8460912
  • 财政年份:
    2010
  • 资助金额:
    $ 22.8万
  • 项目类别:
Signaling pathways for tick salivary secretion
蜱唾液分泌的信号通路
  • 批准号:
    7948408
  • 财政年份:
    2010
  • 资助金额:
    $ 22.8万
  • 项目类别:
Signaling pathways for tick salivary secretion
蜱唾液分泌的信号通路
  • 批准号:
    8065431
  • 财政年份:
    2010
  • 资助金额:
    $ 22.8万
  • 项目类别:
Signaling pathways for tick salivary secretion
蜱唾液分泌的信号通路
  • 批准号:
    8259451
  • 财政年份:
    2010
  • 资助金额:
    $ 22.8万
  • 项目类别:
Neurpeptidergic control of the salivary gland in the black-legged tick, Ixodes sc
黑腿蜱 (Ixodes sc) 唾液腺的神经肽能控制
  • 批准号:
    7573177
  • 财政年份:
    2008
  • 资助金额:
    $ 22.8万
  • 项目类别:
Neurpeptidergic control of the salivary gland in the black-legged tick, Ixodes sc
黑腿蜱 (Ixodes sc) 唾液腺的神经肽能控制
  • 批准号:
    7750582
  • 财政年份:
    2008
  • 资助金额:
    $ 22.8万
  • 项目类别:

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  • 批准号:
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论文研究:血粉来源作为蜱虫媒介 AMBLYOMMA AMERICANUM 中细菌群落动态的生态决定因素
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  • 项目类别:
Dissertation Research: Hosts vs. Habitat: Effects of Forestry Practice on the Abundance of Amblyomma Americanum (Acari: Ixodidae) in Missouri
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