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Development of osmoregulation disruptors for tick control

开发用于蜱控制的渗透调节干扰剂

基本信息

批准号：
10432104
负责人：
Yoonseong Park
金额：
$ 22.8万
依托单位：
KANSAS STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-16 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10432104
关键词：
Adult Amblyomma Ambylomma americanum Anatomy Animals Area Bacteria Bioinformatics Blood Cessation of life Data Dermacentor Dermal Development Environmental Risk Factor Equilibrium Excretory function Formulation Foundations Funding Genes Genome Gland Goals Health Hemolymph Hormonal Human Immunohistochemistry In Situ Hybridization Inorganic Phosphate Transporter Investigation Ion Transport Ixodes Knowledge Lead Link Liquid substance Measures Mechanical Stimulation Mechanics Mediating Metabolic Metabolism Midwestern United States Molecular Na(+)-K(+)-Exchanging ATPase Nymph Organ Osmoregulation Ouabain Pathway interactions Pharmacology Pharmacology Study Physiology Poison Precipitation Process Protozoa Publications Regulation Reporting Rhipicephalus Rickettsia Route Salivary Glands Seasons Serotonin Signal Pathway Sodium System Testing Tick Control Ticks Tissues Toxic Actions Toxic effect Toxicology Transcript Vertebrates Virus Water combinatorial drinking drinking behavior drinking water exhaustion feeding inorganic phosphate ionic balance mechanical stimulus novel pathogen saliva secretion serotonin receptor synergism tick transmission tool transmission process wasting water drinking behavior

项目摘要

Project Summary Ticks are obligatory ectoparasites that feed on vertebrates and transmit pathogens during blood feeding, causing health problems globally in animals and humans. Ticks transmit a wide variety of pathogens, including bacteria (e.g., rickettsia), protozoa, and viruses, and directly damage their hosts. A most significant tick physiology that allows ticks survive in the field is maintaining water balance throughout the lifetime including the off-host periods. The osmoregulatory mechanisms in Metastriata ticks include: 1) directly drinking water through the gut and the salivary glands, 2) losing large amounts of water through dermal secretion, and 3) losing water with excretion of metabolic wastes. The central dogma in this proposal is using the tick water drinking behavior as a route of delivering toxic agents to disrupt the osmoregulatory pathway, which is a vulnerable toxicological target in off-host ticks. Ample preliminary data provides the proof of the concept. Tick deaths could be induced by voluntary drinking of phosphate-rich iso-osmotic solutions and also by thermally induced exhaustive dermal secretion. The aims of the proposals are to develop the tick- specific osmoregulation disruptor (Aim 1) and to investigate the physiology of water loss through tick dermal secretion (Aim 2). In the Aim 1, we will study the physiology of the inorganic phosphate metabolism and phosphate-mediated electrochemical imbalance in the excretory system, which function as a significant osmoregulatory disruptor. Aim2 will uncover the mechanisms of dermal secretion including serotonin-mediated regulation and ion transport mechanisms in the dermal glands, which is a unique organ associated with a loss of large amount (~300 nL) of fluid within a second upon thermal/mechanical stimulation. The strategy using an osmoregulatory disruptor fits well in the hot and dry season in the Midwest and Southwest area of the U.S. where numerous Metastriata ticks, Amblyomma, Dermacentor, Rhipicephalus, and Haemaphysalis, and the pathogen transmission have been reported. The current proposal is to expand the knowledge of the target physiology, linking to the long-term goal in the development of environmentally compatible tick control measures.

项目总结

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Characterization of Iflavirus in the Red Flour Beetle, Tribolium castaneum (Coleoptera; Tenebrionidae).

DOI：
10.3390/insects14030220
发表时间：
2023-02-23
期刊：
Insects
影响因子：
3
作者：
Fatehi S;Aikins M;Philips TW;Brown S;Zhu KY;Scully ED;Park Y
通讯作者：
Park Y

Bee-safe peptidomimetic acaricides achieved by comparative genomics.

DOI：
10.1038/s41598-022-20110-0
发表时间：
2022-10-14
期刊：
SCIENTIFIC REPORTS
影响因子：
4.6
作者：
Jindal, Vikas;Li, Daqi;Rault, Leslie C.;Fatehi, Soheila;Singh, Rupinder;Mating, Moritz;Zou, Ye;Ng, Ho-Leung;Kaczmarek, Krzysztof;Zabrocki, Janusz;Gui, Shunhua;Smagghe, Guy;Anderson, Troy D.;Nachman, Ronald J.;Park, Yoonseong
通讯作者：
Park, Yoonseong

Water absorption through salivary gland type I acini in the blacklegged tick, Ixodes scapularis.