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Prevention and Assessment of Risk in Teens (PART) Longitudinal Study

青少年风险预防和评估（PART）纵向研究

基本信息

批准号：
10435006
负责人：
Nadine M. Melhem
金额：
$ 59.56万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-17 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10435006
关键词：
Address Adolescent Affect Algorithms Anhedonia Belief Black race Caregivers Caring Cellular Phone Childhood Clinic Clinical Data Depression and Suicide Depression screen Discrimination Distress Ecological momentary assessment Electronic Health Record Emergency Situation Ensure Event Feedback Feeling suicidal Focus Groups Funding Goals Grant Health Intervention Interview Knowledge Longitudinal Studies Maps Measures Mediating Mediator of activation protein Medical center Mental Depression Methods Monitor Moods Neighborhoods Patient Self-Report Patients Pediatric Hospitals Performance Philadelphia Physical activity Predictive Analytics Prevention Primary Health Care Provider Randomized Randomized Clinical Trials Readiness Recommendation Recording of previous events Risk Risk Assessment Risk Factors Safety Sampling Services Sleep Disorders Stress Suicide Suicide prevention Teenagers Testing Time Universities Violence Work Youth adolescent suicide aged analytical method base care providers cohort comorbidity data fusion effectiveness implementation study effectiveness testing future implementation health disparity health equity health equity promotion high risk ideation implementation efforts implementation facilitators implementation science improved meetings mobile sensing prediction algorithm preference primary care setting primary outcome protective factors psychosocial recruit reducing suicide response risk stratification routine screening screening service delivery sleep pattern social engagement suicidal suicidal adolescent suicidal behavior suicidal risk suicide attempter suicide rate text messaging intervention tool treatment as usual treatment comparison treatment response

项目摘要

Suicide rates among adolescents have increased dramatically, particularly for Black youth. The majority of suicide decedents have their last clinical contact in primary care. Thus, PPC settings are critical for identifying and treating suicidal youth, but there are challenges with respect to identification, intervention, and implementation. Annual screening for depression using self-report may miss identifying many high-risk youth, as many suicide attempters, particular Black youth, do not report ideation prior to their suicidal behavior and suicidal crises in youth can develop quickly. A second challenge is that once high-risk youth are identified, PPC providers lack a reliable service delivery strategy to effectively treat these youth. A third challenge is that are many barriers for identifying or intervening with Black youth at risk for suicide. Our Signature R01 addresses these challenges as follows: In the first component of the R01, we will develop a predictive analytic platform for PPC based on the electronic health record (EHR), mobile sensing, ecological momentary activity (EMA) assessments of mood and suicidal thoughts and behaviors and self-reports to identify who is at risk and when they are at imminent risk for suicide-related events. To accomplish this, we will recruit 2000 youth from PPC, enriched for those at high suicidal risk, and the sample will be 35% Black. These youth will be followed with interviews and self-reports at 1, 3, and 6 months following baseline and will have 6 months of data from mobile sensing and daily and weekly EMA. We will: (1) develop a predictive algorithm using EHR of adolescents in PPC settings; (2) identify dynamic changes in mobile sensing and EMA measures predicting imminent risk for suicide- related events; (3) develop a data-fusion algorithm combining mobile sensing, EMA, self-reports, and EHR to improve prediction; and (4) test and optimize its performance among Black youth. In the 2nd component, we will conduct a randomized clinical trial (RCT) on a subset of this cohort, namely 900 youth at high suicidal risk. We will compare treatment as usual (TAU) to a suite of tools developed in the current project period to guide the pediatric provider in assessing suicidal risk, making a treatment recommendation, generating a safety plan that is loaded on the patient’s smartphone, and launching an automated texting intervention to increase treatment engagement. Based on our previous work, we hypothesize that this combined intervention, integrated Care to Help At-Risk Teens (iCHART) will decrease suicidal events (suicidal behavior or ideation that results in an emergency referral) by 50%, and the effects will be mediated by increases in referrals, treatment engagement, and safety planning. We will use implementation science methods to assess barriers, facilitators, feasibility, and acceptability of PART predictive analytics and the iCHART intervention to inform future implementation efforts and to promote health equity and ensure that our methods of identification and intervention will be effective and acceptable to Black youth. This study can improve identification and monitoring of youth at risk, reduce suicidal events, and advance health equity for Black youth.

青少年的自杀率急剧上升，尤其是黑人青年。大多数