Bioengineered Skin Sealants

生物工程皮肤密封剂

基本信息

  • 批准号:
    10676763
  • 负责人:
  • 金额:
    $ 37.96万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-08-01 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

Abstract Effective approximation, repair, and healing of soft tissues is a significant challenge in trauma and most cases require rapid, liquid-tight sealing of dermal tissue, which aids fast recovery of tissue biomechanical properties and resists infections. Sutures and staples are commonly used but do not lead to immediate sealing, cause significant tissue trauma, are prone to infection, leave characteristic scars and / or suffer from poor cosmesis, especially in visible areas. Glues, including cyanoacrylate and fibrin, typically result in poor biomechanical recoveries, can be cumbersome to apply, and / or suffer from formulation-dependent toxicities, which limits their application only to superficial use in humans. Laser-activated nanoglues (LANGs) that use non-ionizing light, integrate with tissue to rapidly provide a flight-tight seal, result in better biomechanical recoveries of soft tissues, and demonstrate better cosmesis profiles are attractive alternatives for dermal sealing and repair. The efficacy of LANGs, formulated using silk protein and near infrared light-absorbing nanoparticles (e.g. gold nanorods) or dyes (e.g. indocyanine green), will be investigated for sealing full thickness wounds in live animals. Biomechanical and biochemical characterization will be carried out in order to investigate the efficacy and biocompatibility of LANGs compared to sutures and conventional glues; a combination of LANGs with sutures will also be investigated as a combination approach for enhanced efficacy. In early stages of recovery, sealed tissue is vulnerable and slow healing can lead to complications including surgical-site infections. Small-molecule and protein therapeutics will be formulated with LANGs in order to accelerate closure and repair of dermal incisional wounds particularly at earlier times. Efficacy of LANG sealing and other approximation methods (e.g. sutures) will be visualized using hyperspectral and photoacoustic imaging of the wound site, and the heterogeneity of tissue strain, visualized using digital image correlation, will be investigated as an indicator of potential scarring. A comprehensive picture of LANG-facilitated tissue sealing will thus be generated using a combination of imaging, biomechanical, and biochemical analyses. Wound infections affect up to 500,000 lives each year, and are associated with a greater risk of death compared to patients without infection. LANGs will be formulated with antibacterial drugs in order to simultaneously seal wounds, engender accelerated repair and combat methicillin-resistant S. aureus (MRSA), which is the most common pathogen in community hospitals. Our research will lead to novel, multifunctional LANGs that demonstrate high efficacy for sealing, delivery of drugs for accelerating closure and early-stage repair, and combat infections. We anticipate that LANGs will be translated particularly in applications where rapid dermal sealing and accelerated repair are desired, sutures and staples have limited efficacy, infection control is critical and / or where there is a need for improved cosmesis performance.
摘要

项目成果

期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Alpha-ketoglutaric acid based polymeric particles for cutaneous wound healing.
  • DOI:
    10.1002/jbm.a.37539
  • 发表时间:
    2023-09
  • 期刊:
  • 影响因子:
    4.9
  • 作者:
    Jaggarapu, Madhan M. C. S.;Ghosh, Deepanjan;Johnston, Tyler;Yaron, Jordan R.;Mangal, Joslyn L.;Inamdar, Sahil;Gosangi, Mallikarjun;Rege, Kaushal;Acharya, Abhinav P.
  • 通讯作者:
    Acharya, Abhinav P.
The under-appreciated world of the serpin family of serine proteinase inhibitors.
  • DOI:
    10.15252/emmm.202217144
  • 发表时间:
    2023-06-07
  • 期刊:
  • 影响因子:
    11.1
  • 作者:
  • 通讯作者:
Viral SERPINS-A Family of Highly Potent Immune-Modulating Therapeutic Proteins.
  • DOI:
    10.3390/biom13091393
  • 发表时间:
    2023-09-15
  • 期刊:
  • 影响因子:
    5.5
  • 作者:
  • 通讯作者:
Chronological Impact of Earthquakes on Blood Pressure: A Literature Review and Retrospective Study of Hypertension in Haiti Before and After the 2010 Earthquake.
  • DOI:
    10.3389/fpubh.2020.600157
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    5.2
  • 作者:
    Fath AR;Aglan A;Platt J;Yaron JR;Varkoly KS;Beladi RN;Gorgas D;Jean JT;Dasni P;Eldaly AS;Juby M;Lucas AR
  • 通讯作者:
    Lucas AR
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Kaushal Rege其他文献

Kaushal Rege的其他文献

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{{ truncateString('Kaushal Rege', 18)}}的其他基金

Near Infrared Light Activated Adhesives for Nerve Repair
用于神经修复的近红外光激活粘合剂
  • 批准号:
    10436799
  • 财政年份:
    2021
  • 资助金额:
    $ 37.96万
  • 项目类别:
Laser-Activated Nanoglues for the prevention and control of surgical site infections
激光激活纳米胶用于预防和控制手术部位感染
  • 批准号:
    10249234
  • 财政年份:
    2020
  • 资助金额:
    $ 37.96万
  • 项目类别:
Bioengineered Skin Sealants
生物工程皮肤密封剂
  • 批准号:
    10457977
  • 财政年份:
    2020
  • 资助金额:
    $ 37.96万
  • 项目类别:
DEVELOPMENT OF NOVEL AMINOGLYCOSIDE POLYMERS AND NANOPARTICLES FOR NUCLEIC ACID DELIVERY IN CHRONIC WOUNDS
开发用于慢性伤口核酸输送的新型氨基糖苷聚合物和纳米颗粒
  • 批准号:
    10009545
  • 财政年份:
    2020
  • 资助金额:
    $ 37.96万
  • 项目类别:
Bioengineered Skin Sealants
生物工程皮肤密封剂
  • 批准号:
    10226324
  • 财政年份:
    2020
  • 资助金额:
    $ 37.96万
  • 项目类别:
Bioengineered Skin Sealants
生物工程皮肤密封剂
  • 批准号:
    10053067
  • 财政年份:
    2020
  • 资助金额:
    $ 37.96万
  • 项目类别:
Photothermal Nanocomposites for Tissue Repair
用于组织修复的光热纳米复合材料
  • 批准号:
    8945323
  • 财政年份:
    2015
  • 资助金额:
    $ 37.96万
  • 项目类别:
Engineering DNA Delivery Polymers using Combinatorial and Cheminformatics Methods
使用组合和化学信息学方法设计 DNA 递送聚合物
  • 批准号:
    8602837
  • 财政年份:
    2011
  • 资助金额:
    $ 37.96万
  • 项目类别:
Engineering DNA Delivery Polymers using Combinatorial and Cheminformatics Methods
使用组合和化学信息学方法设计 DNA 递送聚合物
  • 批准号:
    8212217
  • 财政年份:
    2011
  • 资助金额:
    $ 37.96万
  • 项目类别:
Engineering DNA Delivery Polymers using Combinatorial and Cheminformatics Methods
使用组合和化学信息学方法设计 DNA 递送聚合物
  • 批准号:
    8416396
  • 财政年份:
    2011
  • 资助金额:
    $ 37.96万
  • 项目类别:

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