Development of a liver viability index for transplantation
移植肝活力指数的制定
基本信息
- 批准号:10436293
- 负责人:
- 金额:$ 37.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-08-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AdoptionAlgorithm DesignAlgorithmsAllograftingBiological MarkersBiopsyCadaverCardiac DeathCessation of lifeChargeClinicalClinical DataClinical ResearchComplementComplexControl GroupsCryopreservationDataDevelopmentDevicesDonor personEnergy MetabolismEngineeringEnsureFunctional disorderFundingGoalsGraft SurvivalHumanIschemiaLeast-Squares AnalysisLiverLiver CirrhosisMass Spectrum AnalysisMeasuresMetabolicMethodsModelingOrganOrgan DonorOrgan PreservationOrgan ViabilityOutcomePatient-Focused OutcomesPatientsPerfusionPotential EnergyProcessProgress ReportsProtocols documentationRattusRecoveryRegression AnalysisResearchResuscitationRiskScienceSiteSystemTechnologyTestingTimeTissuesTrainingTransaminasesTransplant RecipientsTransplantationTransplantation SurgeryUnited Network for Organ SharingValidationWaiting ListsWorkbasebody systemchronic liver diseaseclinical predictorsclinical translationdesignend stage liver diseasegraft failuregraft functionin vivoindexingliver functionliver metabolismliver transplantationmetabolomicsoutcome predictionpost-transplantpotential biomarkerpreservationpublic health relevancescale upsuccesssurvival prediction
项目摘要
ABSTRACT
Chronic liver disease and cirrhosis causes up 60,000 deaths annually in the US, over 4,000 of which are
directly due to lack of a donor liver available for transplant. These numbers could be reduced dramatically
should the donor organ pool be expanded by rendering marginal cases, such as Donors obtained after Cardiac
Death (DCD), transplantable. It is estimated that about 6,000 cadaveric livers/yr are only marginally damaged
by ischemia post-cardiac death and could be resuscitated for transplantation. There is evidence from our lab
and others that machine perfusion is a very promising approach for recovering cadaveric organs that would be
otherwise rejected from the donor pool. However, safe and effective clinical realization of such a machine
perfusion device requires sophisticated algorithms that ensure tight control of the system, maximize the
viability of the organ and accurately assess if the liver is ready for transplantation at the end of perfusion. There
is a significant gap of methods and algorithms designed for assessing organ viability for transplantation in a
quantitative and objective manner, which is a major bottleneck in clinical translation of marginal organ recovery
technologies and vertical advancement of the field.
Our long-term goal is to maximize the use of donor organs while ensuring the graft success upon
transplant. The objective of the proposed study is to develop and test a dynamic, online method to assess liver
transplant success in a small clinical study. The central hypothesis to be tested here is that the liver survival
post-transplantation is correlated to its energy state and energy metabolism during machine perfusion.
The work described here is expected to create a dynamic, on-line liver viability score which can be used to
assess the condition of the donor organs prior to transplantation surgery, ultimately reducing the guesswork
involved in transplantation and consequently increasing the use of marginal donor organs reducing deaths due
to graft failure. This development is anticipated to increase the pace of clinical adoption of machine perfusion
preservation studies for the liver, as well as other organs. The results of this work will also have a positive
impact on engineering science by establishing the basis for integration of process design & control of these
complex, dynamic organ preservation systems.
摘要
项目成果
期刊论文数量(39)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)
Bulk Droplet Vitrification for Primary Hepatocyte Preservation.
用于原代肝细胞保存的散装液滴玻璃化冷冻。
- DOI:10.3791/60250
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:deVries,ReinierJ;Banik,PeonyD;Nagpal,Sonal;Weng,Lindong;Ozer,Sinan;vanGulik,ThomasM;Toner,Mehmet;Tessier,ShannonN;Uygun,Korkut
- 通讯作者:Uygun,Korkut
Strategies to rescue steatotic livers before transplantation in clinical and experimental studies.
- DOI:10.3748/wjg.v19.i29.4638
- 发表时间:2013-08
- 期刊:
- 影响因子:4.3
- 作者:Qiang Liu;M. Izamis;Hongzhi Xu;T. Berendsen;M. Yarmush;K. Uygun
- 通讯作者:Qiang Liu;M. Izamis;Hongzhi Xu;T. Berendsen;M. Yarmush;K. Uygun
A simplified subnormothermic machine perfusion system restores ischemically damaged liver grafts in a rat model of orthotopic liver transplantation.
- DOI:10.1186/2047-1440-1-6
- 发表时间:2012-05-09
- 期刊:
- 影响因子:0
- 作者:Berendsen TA;Bruinsma BG;Lee J;D'Andrea V;Liu Q;Izamis ML;Uygun K;Yarmush ML
- 通讯作者:Yarmush ML
Polyethylene Glycol and Caspase Inhibitor Emricasan Alleviates Cold Injury in Primary Rat Hepatocytes.
聚乙二醇和半胱天冬酶抑制剂 Emricasan 减轻原代大鼠肝细胞的冷损伤。
- DOI:10.21203/rs.3.rs-3669876/v1
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Chen,Huyun;Ellis,BradleyW;Dinicu,AntoniaT;Mojoudi,Mohammadreza;Wilks,BenjaminT;Tessier,ShannonN;Toner,Mehmet;Uygun,Korkut;Uygun,BasakE
- 通讯作者:Uygun,BasakE
Subzero organ preservation: the dawn of a new ice age?
- DOI:10.1097/mot.0000000000000403
- 发表时间:2017-06
- 期刊:
- 影响因子:2.2
- 作者:Bruinsma BG;Uygun K
- 通讯作者:Uygun K
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Korkut Uygun其他文献
Korkut Uygun的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Korkut Uygun', 18)}}的其他基金
Subzero Non-freezing preservation of whole mammalian organisms
整个哺乳动物有机体的零下非冷冻保存
- 批准号:
10451256 - 财政年份:2022
- 资助金额:
$ 37.91万 - 项目类别:
Subzero Non-freezing preservation of whole mammalian organisms
整个哺乳动物有机体的零下非冷冻保存
- 批准号:
10705577 - 财政年份:2022
- 资助金额:
$ 37.91万 - 项目类别:
Enhanced recovery of disqualified donor organs using image-guided machine perfusion
使用图像引导机器灌注加速不合格供体器官的恢复
- 批准号:
8831396 - 财政年份:2014
- 资助金额:
$ 37.91万 - 项目类别:
Metabolic Modeling for Cadaveric Organ Resuscitation
尸体器官复苏的代谢模型
- 批准号:
8518094 - 财政年份:2012
- 资助金额:
$ 37.91万 - 项目类别:
Metabolic Modeling for Cadaveric Organ Resuscitation
尸体器官复苏的代谢模型
- 批准号:
8343269 - 财政年份:2012
- 资助金额:
$ 37.91万 - 项目类别:
Development of a liver viability index for transplantation
移植肝活力指数的制定
- 批准号:
9977766 - 财政年份:2012
- 资助金额:
$ 37.91万 - 项目类别:
Metabolic Modeling for Cadaveric Organ Resuscitation
尸体器官复苏的代谢模型
- 批准号:
9115174 - 财政年份:2012
- 资助金额:
$ 37.91万 - 项目类别:
Development of a liver viability index for transplantation
移植肝活力指数的制定
- 批准号:
10205042 - 财政年份:2012
- 资助金额:
$ 37.91万 - 项目类别:
Development of a liver viability index for transplantation
移植肝活力指数的制定
- 批准号:
9770638 - 财政年份:2012
- 资助金额:
$ 37.91万 - 项目类别:
相似海外基金
REU Site: Algorithm Design --- Theory and Engineering
REU网站:算法设计---理论与工程
- 批准号:
2349179 - 财政年份:2024
- 资助金额:
$ 37.91万 - 项目类别:
Standard Grant
REU Site: Quantum Machine Learning Algorithm Design and Implementation
REU 站点:量子机器学习算法设计与实现
- 批准号:
2349567 - 财政年份:2024
- 资助金额:
$ 37.91万 - 项目类别:
Standard Grant
Product structures theorems and unified methods of algorithm design for geometrically constructed graphs
几何构造图的乘积结构定理和算法设计统一方法
- 批准号:
23K10982 - 财政年份:2023
- 资助金额:
$ 37.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Algorithm Design in Strategic and Uncertain Environments
战略和不确定环境中的算法设计
- 批准号:
RGPIN-2016-03885 - 财政年份:2022
- 资助金额:
$ 37.91万 - 项目类别:
Discovery Grants Program - Individual
Human-Centered Algorithm Design for High Stakes Decision-Making in Public Services
以人为本的公共服务高风险决策算法设计
- 批准号:
DGECR-2022-00401 - 财政年份:2022
- 资助金额:
$ 37.91万 - 项目类别:
Discovery Launch Supplement
Human-Centered Algorithm Design for High Stakes Decision-Making in Public Services
以人为本的公共服务高风险决策算法设计
- 批准号:
RGPIN-2022-04570 - 财政年份:2022
- 资助金额:
$ 37.91万 - 项目类别:
Discovery Grants Program - Individual
Control Theory and Algorithm Design for Nonlinear Systems Based on Finite Dimensionality of Holonomic Functions
基于完整函数有限维的非线性系统控制理论与算法设计
- 批准号:
22K17855 - 财政年份:2022
- 资助金额:
$ 37.91万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Scalable Algorithm Design for Unbiased Estimation via Couplings of Markov Chain Monte Carlo Methods
通过马尔可夫链蒙特卡罗方法耦合进行无偏估计的可扩展算法设计
- 批准号:
2210849 - 财政年份:2022
- 资助金额:
$ 37.91万 - 项目类别:
Continuing Grant
Modern mathematical models of big data-driven problems in biological sequence analysis with applications to efficient algorithm design
生物序列分析中大数据驱动问题的现代数学模型及其在高效算法设计中的应用
- 批准号:
569312-2022 - 财政年份:2022
- 资助金额:
$ 37.91万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Doctoral