Development of a liver viability index for transplantation

移植肝活力指数的制定

基本信息

  • 批准号:
    10436293
  • 负责人:
  • 金额:
    $ 37.91万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-08-01 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

ABSTRACT Chronic liver disease and cirrhosis causes up 60,000 deaths annually in the US, over 4,000 of which are directly due to lack of a donor liver available for transplant. These numbers could be reduced dramatically should the donor organ pool be expanded by rendering marginal cases, such as Donors obtained after Cardiac Death (DCD), transplantable. It is estimated that about 6,000 cadaveric livers/yr are only marginally damaged by ischemia post-cardiac death and could be resuscitated for transplantation. There is evidence from our lab and others that machine perfusion is a very promising approach for recovering cadaveric organs that would be otherwise rejected from the donor pool. However, safe and effective clinical realization of such a machine perfusion device requires sophisticated algorithms that ensure tight control of the system, maximize the viability of the organ and accurately assess if the liver is ready for transplantation at the end of perfusion. There is a significant gap of methods and algorithms designed for assessing organ viability for transplantation in a quantitative and objective manner, which is a major bottleneck in clinical translation of marginal organ recovery technologies and vertical advancement of the field. Our long-term goal is to maximize the use of donor organs while ensuring the graft success upon transplant. The objective of the proposed study is to develop and test a dynamic, online method to assess liver transplant success in a small clinical study. The central hypothesis to be tested here is that the liver survival post-transplantation is correlated to its energy state and energy metabolism during machine perfusion. The work described here is expected to create a dynamic, on-line liver viability score which can be used to assess the condition of the donor organs prior to transplantation surgery, ultimately reducing the guesswork involved in transplantation and consequently increasing the use of marginal donor organs reducing deaths due to graft failure. This development is anticipated to increase the pace of clinical adoption of machine perfusion preservation studies for the liver, as well as other organs. The results of this work will also have a positive impact on engineering science by establishing the basis for integration of process design & control of these complex, dynamic organ preservation systems.
摘要

项目成果

期刊论文数量(39)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)
Bulk Droplet Vitrification for Primary Hepatocyte Preservation.
用于原代肝细胞保存的散装液滴玻璃化冷冻。
  • DOI:
    10.3791/60250
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    deVries,ReinierJ;Banik,PeonyD;Nagpal,Sonal;Weng,Lindong;Ozer,Sinan;vanGulik,ThomasM;Toner,Mehmet;Tessier,ShannonN;Uygun,Korkut
  • 通讯作者:
    Uygun,Korkut
Strategies to rescue steatotic livers before transplantation in clinical and experimental studies.
  • DOI:
    10.3748/wjg.v19.i29.4638
  • 发表时间:
    2013-08
  • 期刊:
  • 影响因子:
    4.3
  • 作者:
    Qiang Liu;M. Izamis;Hongzhi Xu;T. Berendsen;M. Yarmush;K. Uygun
  • 通讯作者:
    Qiang Liu;M. Izamis;Hongzhi Xu;T. Berendsen;M. Yarmush;K. Uygun
A simplified subnormothermic machine perfusion system restores ischemically damaged liver grafts in a rat model of orthotopic liver transplantation.
  • DOI:
    10.1186/2047-1440-1-6
  • 发表时间:
    2012-05-09
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Berendsen TA;Bruinsma BG;Lee J;D'Andrea V;Liu Q;Izamis ML;Uygun K;Yarmush ML
  • 通讯作者:
    Yarmush ML
Polyethylene Glycol and Caspase Inhibitor Emricasan Alleviates Cold Injury in Primary Rat Hepatocytes.
聚乙二醇和半胱天冬酶抑制剂 Emricasan 减轻原代大鼠肝细胞的冷损伤。
  • DOI:
    10.21203/rs.3.rs-3669876/v1
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Chen,Huyun;Ellis,BradleyW;Dinicu,AntoniaT;Mojoudi,Mohammadreza;Wilks,BenjaminT;Tessier,ShannonN;Toner,Mehmet;Uygun,Korkut;Uygun,BasakE
  • 通讯作者:
    Uygun,BasakE
Subzero organ preservation: the dawn of a new ice age?
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Korkut Uygun其他文献

Korkut Uygun的其他文献

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{{ truncateString('Korkut Uygun', 18)}}的其他基金

Subzero Non-freezing preservation of whole mammalian organisms
整个哺乳动物有机体的零下非冷冻保存
  • 批准号:
    10451256
  • 财政年份:
    2022
  • 资助金额:
    $ 37.91万
  • 项目类别:
Subzero Non-freezing preservation of whole mammalian organisms
整个哺乳动物有机体的零下非冷冻保存
  • 批准号:
    10705577
  • 财政年份:
    2022
  • 资助金额:
    $ 37.91万
  • 项目类别:
Enhanced recovery of disqualified donor organs using image-guided machine perfusion
使用图像引导机器灌注加速不合格供体器官的恢复
  • 批准号:
    8831396
  • 财政年份:
    2014
  • 资助金额:
    $ 37.91万
  • 项目类别:
High Yield Human Hepatocyte Isolation
高产人肝细胞分离
  • 批准号:
    8589502
  • 财政年份:
    2013
  • 资助金额:
    $ 37.91万
  • 项目类别:
Metabolic Modeling for Cadaveric Organ Resuscitation
尸体器官复苏的代谢模型
  • 批准号:
    8518094
  • 财政年份:
    2012
  • 资助金额:
    $ 37.91万
  • 项目类别:
Metabolic Modeling for Cadaveric Organ Resuscitation
尸体器官复苏的代谢模型
  • 批准号:
    8343269
  • 财政年份:
    2012
  • 资助金额:
    $ 37.91万
  • 项目类别:
Development of a liver viability index for transplantation
移植肝活力指数的制定
  • 批准号:
    9977766
  • 财政年份:
    2012
  • 资助金额:
    $ 37.91万
  • 项目类别:
Metabolic Modeling for Cadaveric Organ Resuscitation
尸体器官复苏的代谢模型
  • 批准号:
    9115174
  • 财政年份:
    2012
  • 资助金额:
    $ 37.91万
  • 项目类别:
Development of a liver viability index for transplantation
移植肝活力指数的制定
  • 批准号:
    10205042
  • 财政年份:
    2012
  • 资助金额:
    $ 37.91万
  • 项目类别:
Development of a liver viability index for transplantation
移植肝活力指数的制定
  • 批准号:
    9770638
  • 财政年份:
    2012
  • 资助金额:
    $ 37.91万
  • 项目类别:

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