Training in Multi-Modality Molecular and Transitional Cardiovascular Imaging

多模态分子和过渡心血管成像培训

• 批准号: 10436344
• 负责人: JAMES S DUNCAN
• 金额: $ 49.28万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-21 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10436344
• 关键词: Molecular; Training; cardiovascular imaging; multimodality

This is the revision of a second competitive renewal of a currently funded T32 grant that received a very favorable initial review. This grant provides post-doctoral training in multi-disciplinary multi-modality molecular and translational cardiovascular imaging for highly qualified fellows holding either a MD or/and PhD, in preparation for academic careers as independent investigators in the highly clinically relevant field of cardiovascular imaging and image guided intervention. As imaging technology and molecular medicine advances, increasingly complex questions often arise requiring the convergence of perspectives from multiple disciplines. The future of cardiovascular imaging will most likely be practiced by integrated multidisciplinary teams with diverse areas of expertise. The goal of this research training program is to provide the necessary skills needed to work in this new multi-disciplinary investigative environment. Applicants will be recruited from both clinical and basic science departments, with attention paid to recruitment of female, minority, disabled, and disadvantaged candidates. We will continue to select and enroll applicants to maintain support for 6 post- doctoral fellows each year, with an equal balance of physicians and scientists. We have added a new pathway that focuses on image-guided therapy, and have expanded the image analysis pathway to include specific training in machine and deep learning provided by the recently established Translational Image Analysis and Machine Learning (TIAML) Center and partnering with data science center at the university. Post-doctoral fellowship training will be 2-3 years in duration. There will be four primary research focuses in the post-doctoral training, 1) cardiovascular molecular imaging, 2) cardiovascular imaging technologies and analyses, 3) image guided therapy, and 4) translational cardiovascular imaging. The primary faculty for this program are from the Department of Biomedical Engineering of the Yale School of Engineering and Applied Sciences and from multiple departments within the Yale School of Medicine, including: Internal Medicine (Section of Cardiovascular Medicine), Radiology & Biomedical Imaging, and Surgery. The faculty sponsors have been selected based on extramural support, research productivity, and commitment to multi-disciplinary training. Each trainee will be assigned a primary preceptor in the basic sciences and engineering or clinical research and co-mentor with complementary expertise. Trainee progress will be monitored by individual mentors, the trainee’s advisory committee, and the Program Directors. Drs. Sinusas and Duncan will co-manage the program to assure a balanced and integrated experience in the relevant clinical and engineering sciences. We have also established a more formal relationship between our T32 training program and the Vascular Biology T32 training program within the section of Cardiovascular Medicine and will establish an annual research retreat with fellow presentations of research in progress. This retreat should help to better integrate basic, translational and clinical research within the Section of Cardiology and other participating departments.

这是对当前资助的T32赠款的第二次竞争续约的修订 有利的初始评论。该赠款提供了多学科多模式分子的博士后培训 并翻译了持有MD或/和博士学位的高素质研究员的心血管成像， 作为高度临床相关领域的独立研究人员为学术职业做准备 心血管成像和图像引导干预。作为成像技术和分子医学 进步，越来越复杂的问题通常会出现，需要多个观点的融合 学科。心血管成像的未来很可能会通过综合多学科实践 具有专业知识的潜水员领域的团队。该研究培训计划的目标是提供必要的 在这个新的多学科调查环境中工作所需的技能。申请人将从 临床和基础科学部门都注意招募女性，少数族裔，残疾人， 和不利的候选人。我们将继续选择和注册申请，以维持6个后的支持 - 每年的博士研究员，医生和科学家平衡。我们添加了一个新的途径 重点是图像引导的治疗，并扩大了图像分析途径以包括特定 最近建立的翻译图像分析提供的机器和深度学习培训 机器学习（TIAML）中心，并与大学数据科学中心合作。博士后 奖学金培训的持续时间为2 - 3年。博士后将有四项主要研究重点 训练，1）心血管分子成像，2）心血管成像技术和分析，3）图像 指导疗法和4）翻译的心血管成像。该计划的主要教师来自 耶鲁大学工程和应用科学学院生物医学工程系以及来自 耶鲁大学医学院的多个部门，包括：内科 心血管医学），放射学和生物医学成像以及手术。教师赞助商一直 根据壁外支持​​，研究生产力和对多学科培训的承诺选择。 每个学员将被分配为基础科学和工程或临床研究的主要受体 并拥有完整的专业知识。学员进步将由个人导师监视 实习生的咨询委员会和计划主管。博士。窦和邓肯将共同管理 计划在相关的临床和工程科学方面具有平衡和综合的经验。我们 我们的T32培训计划与血管生物学之间还建立了更正式的关系 T32培训计划在心血管医学部分，将建立年度研究 务虚会进行研究的研究。此务虚会应有助于更好地整合基本， 心脏病学和其他参与部门的转化和临床研究。