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CardioPulmonary Vascular Biology COBRE

心肺血管生物学 COBRE

基本信息

批准号：
10437828
负责人：
Gaurav Choudhary
金额：
$ 202.59万
依托单位：
OCEAN STATE RESEARCH INSTITUTE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-20 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10437828
关键词：
Affect Area Biology Blood Vessels Cardiopulmonary Cardiovascular Diseases Cardiovascular system Cell Separation Centers of Research Excellence Collaborations Communities Development Discipline Disease Education Educational process of instructing Faculty Funding Health Hematological Disease Hospitals Institution Knowledge Lung Lung diseases Medical center Mentors Oceans Organ Performance Phase Pilot Projects Program Development Research Research Institute Research Personnel Research Support Resources Rhode Island Science Scientist Services Teaching Hospitals Time Universities Vascular Diseases Vision career career development graduate student injury and repair innovation interdisciplinary collaboration interest medical schools multidisciplinary research and development skills skills training tool undergraduate student vascular injury

项目摘要

The vision of the CardioPulmonary Vascular Biology Center of Biomedical Research Excellence (CPVB COBRE) is to advance understanding of vascular diseases affecting the pulmonary and cardiovascular systems. This vision will be accomplished through research performed by a multidisciplinary group of outstanding investigators who are using cutting edge tools to understand the pathobiology of vascular diseases. In this phase II application we seek to renew funding for a second 5 years. We will continue the research partnership of three collaborating institutions—Ocean State Research Institute (OSRI), the Rhode Island Hospital, and Brown University. The applicant institution, OSRI, is the research and education nonprofit associated with the Providence VA Medical Center, a teaching hospital affiliated with the Warren Alpert Medical School of Brown University. In Phase I, the CPVB COBRE supported development of a community of researchers, provided career development and research skill training, and stimulated new research collaborations among the investigators, mentors, and other faculty. Strong institutional support brought expert visitors to the center, resulting in additional research collaborations. Teaching and mentoring activities of CPVB COBRE investigators enhanced knowledge of vascular biology among undergraduate and graduate students, as well as postdoctoral trainees and junior faculty. CPVB COBRE investigators have competed successfully for $7.61 million in research funding during Phase I. Similar approaches will be used during Phase II, and five outstanding junior investigators have been identified who bring complementary backgrounds, skills, and research interests. New areas of research will be pursued using innovative approaches that expand the scope of COBRE technical resources. Thus, the CPVB COBRE will continue to broaden the scope and depth of vascular biology research at the partnering Rhode Island institutions. The CardioPulmonary Vascular Biology COBRE proposes the following specific aims for Phase II of funding: (1) Create a multidisciplinary group of investigators in studies of vascular injury and repair. (2) Provide research support, protected time, and mentoring to enable junior investigators to become independent scientists and provide robust support for research career and professional development. (3) Expand the CardioPulmonary Vascular Biology Center into new research areas and thereby enhance and broaden vascular biology research at collaborating institutions. (4) Provide services supporting vascular biology research and develop a self-sustaining Cell/Organ Core. Accomplishment of these aims will result in a strengthened and broadened CardioPulmonary Vascular Biology COBRE that will be the basis for new interdisciplinary scientific collaborations, significant contributions to understanding of pulmonary and cardiovascular diseases, and improvements in the health of the citizens of Rhode Island and the nation.

心肺血管生物学卓越生物医学研究中心 (CPVB) 的愿景 COBRE）旨在增进对影响肺部和心血管的血管疾病的了解系统。这一愿景将通过多学科小组进行的研究来实现使用尖端工具了解血管病理学的杰出研究人员疾病。在第二阶段申请中，我们寻求第二个五年的资助。我们将继续三个合作机构的研究伙伴关系——海洋国家研究所 (OSRI)、罗德岛岛屿医院和布朗大学。申请机构 OSRI 是一家研究和教育非营利组织与普罗维登斯退伍军人医疗中心（Warren Alpert 附属教学医院）有联系布朗大学医学院。在第一阶段，CPVB COBRE 支持社区的发展研究人员，提供职业发展和研究技能培训，并激发新的研究研究人员、导师和其他教师之间的合作。强大的机构支持带来专家中心的访客，从而产生更多的研究合作。教学和指导活动 CPVB COBRE 研究人员增强了本科生和研究生的血管生物学知识学生、博士后实习生和初级教师。 CPVB COBRE 研究人员已完成比赛第一阶段成功获得 761 万美元的研究经费。第二阶段将使用类似的方法 II，并确定了五名杰出的初级研究员，他们带来了互补的背景、技能、和研究兴趣。将使用创新方法来探索新的研究领域，以扩大研究范围 COBRE 技术资源的范围。因此，CPVB COBRE 将不断拓宽范围和深度罗德岛州合作机构的血管生物学研究。心肺血管生物学COBRE提出第二阶段资助的具体目标：（1）创建一个多学科的血管损伤和修复研究的研究人员小组。 (2) 提供研究支持、保护时间、和指导，使初级研究人员成为独立科学家，并为研究生涯和专业发展。（3）将心肺血管生物学中心扩建为新的研究领域，从而加强和扩大合作机构的血管生物学研究。 (4) 提供支持血管生物学研究的服务并开发自我维持的细胞/器官核心。这些目标的实现将加强和拓宽心肺血管生物学 COBRE 将成为新的跨学科科学合作的基础，对了解肺部和心血管疾病，并改善公民的健康罗德岛州和国家。

项目成果

期刊论文数量（117）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（1）

BLOCKADE OF ENDOTHELIAL GROWTH FACTOR, ANGIOPOIETIN-2, REDUCES INDICES OF ARDS AND MORTALITY IN MICE RESULTING FROM THE DUAL-INSULTS OF HEMORRHAGIC SHOCK AND SEPSIS.

DOI：
10.1097/shk.0000000000000499
发表时间：
2016-02
期刊：
Shock (Augusta, Ga.)
影响因子：
0
作者：
Lomas-Neira JL;Heffernan DS;Ayala A;Monaghan SF
通讯作者：
Monaghan SF

Phospholipid scramblase-1 regulates innate type 2 inflammation in mouse lungs via CRTH2-dependent mechanisms.

DOI：
10.1172/jci169583
发表时间：
2023-08-01
期刊：
JOURNAL OF CLINICAL INVESTIGATION
影响因子：
15.9
作者：
Hernandez-Gutierrez, Ashley;Majid, Sonoor;Eberle, Adam;Choi, Ashley;Sorkhdini, Parand;Yang, Dongqin;Yang, Alina Xiaoyu;Norbrun, Carmelissa;He, Chuan Hua;Lee, Chun Geun;Elias, Jack A.;Zhou, Yang
通讯作者：
Zhou, Yang

Targeting RUNX1 as a novel treatment modality for pulmonary arterial hypertension.