Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Coordinating Center- Supplement

HIV/AIDS 干预青少年医学试验网络 (ATN) 协调中心 - 补充资料

• 批准号: 10444497
• 负责人: Michael G Hudgens
• 金额: $ 499.14万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-03 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10444497
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent Medicine Trials Network; Adolescent Risk Behavior; Award; Awareness; Behavioral; Clinical; Coitus; Collaborations; Communication; Communities; Continuity of Patient Care; Data; Development; Ensure; Foundations; Funding; Goals; HIV; HIV Infections; Health Services Accessibility; High School Student; Human immunodeficiency virus test; Individual; Intervention; Intervention Studies; Leadership; Methods; National Institute of Child Health and Human Development; Operations Research; Parental Consent; Pharmaceutical Preparations; Preparation; Prevention trial; Protocols documentation; Publications; Reporting; Research; Research Support; Risk; Risk Behaviors; Solid; Students; Surveys; United States National Institutes of Health; Youth; adolescent health; condoms; design; experience; peer influence; programs; research study; self esteem; sexual encounter; social stigma; support network; young adult

ABSTRACT The goal of this U24 application is to extend our five-year award as Coordinating Center (CC) for the NICHD-sponsored Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) for one additional year. The objective of ATN is to increase awareness among at-risk youth of their HIV status and, for those with HIV, achieve linkage, engagement and retention in the care continuum. Many challenges are faced by adolescents during their transition to young adulthood, resulting from developmental changes, peer influences, identity, and self-esteem formation. Risky behaviors among adolescents, which include engaging in unprotected sexual encounters or sharing nonsterile injecting drug paraphernalia, increase their likelihood of acquiring HIV infection. In the 2013 US Youth Risk Behavior Surveillance Survey (YRBSS), 34% of US high school students reported sexual intercourse during the prior 3 months, of which only 59% indicated condom use during last sexual intercourse. The YRBSS also found that only 13% of students had ever been tested for HIV infection. Given the global burden of new HIV infections among young people, greater involvement of adolescents in biomedical and behavioral HIV research is essential. However, significant individual, operational, and community-level barriers have been recognized to engaging adolescents in clinical prevention trials, which include insufficient understanding of research, need for parental consent, lack of access, mistrust and stigma associated with research participation. For the past five years, the ATN has developed and implemented a comprehensive research portfolio to address these issues. As ATN Coordinating Center, we have supported the Network's research by providing scientific leadership and organizational support for ATN research studies and programs. During this extension year, we will continue to emphasize collaboration and provide experienced leadership to complete and close-out research studies across the network and disseminate findings through our various communication channels. Our research operations and administration teams will continue to provide a solid foundation to ATN by facilitating communication, conducting cross-protocol analyses to leverage Network research, supporting submission of study data to DASH, and supporting abstract and publication preparation and submission. This extension year will allow the extraordinary research conducted during this funding cycle of the ATN to be completed and disseminated for maximum impact on the health of adolescents at risk for or living with HIV/AIDS.

抽象的 此 U24 申请的目标是延长我们作为协调中心 (CC) 的五年奖励 NICHD 赞助的艾滋病毒/艾滋病干预青少年医学试验网络 (ATN) 新增一项 年。 ATN 的目标是提高高危青少年对其艾滋病毒感染状况的认识，并提高那些患有艾滋病毒的青少年的认识。 艾滋病毒，在护理连续体中实现联系、参与和保留。面临诸多挑战 青少年在向青年期过渡期间，由于发育变化、同伴影响、 身份和自尊的形成。青少年中的危险行为，包括参与 无保护的性行为或共用未经消毒的注射吸毒用具，会增加他们感染毒品的可能性 感染艾滋病毒。在 2013 年美国青少年危险行为监测调查 (YRBSS) 中，34% 的美国高 学生报告在过去 3 个月内发生过性行为，其中只有 59% 表示使用安全套 在上次性交时使用。 YRBSS 还发现，只有 13% 的学生接受过测试 艾滋病毒感染。鉴于年轻人中新发艾滋病毒感染的全球负担，更多人的参与 青少年的生物医学和行为艾滋病毒研究至关重要。然而，重要的个人， 已认识到让青少年参与临床预防的操作和社区层面的障碍 试验，包括对研究了解不足、需要父母同意、缺乏接触机会、不信任 以及与参与研究相关的耻辱。在过去的五年里，ATN 已经发展并 实施了全面的研究组合来解决这些问题。作为 ATN 协调中心，我们 通过为 ATN 提供科学领导和组织支持来支持网络的研究 研究和计划。在这延长的一年里，我们将继续强调合作和 提供经验丰富的领导力来完成和结束整个网络的研究， 通过我们的各种沟通渠道传播调查结果。我们的研究运作和管理 团队将继续通过促进沟通、开展 跨协议分析以利用网络研究，支持向 DASH 提交研究数据，以及 支持摘要和出版物的准备和提交。这个延长年将允许 在 ATN 的本资助周期内进行的非凡研究将完成并传播给 对有艾滋病毒/艾滋病风险或感染艾滋病毒/艾滋病的青少年的健康产生最大影响。

项目成果

Randomized Controlled Trial of a Remote Coaching mHealth Adherence Intervention in Youth Living with HIV.

• DOI: 10.1007/s10461-022-03717-2
• 发表时间: 2022-12
• 期刊: AIDS and behavior
• 影响因子: 4.4
• 作者: Amico KR;Lindsey JC;Hudgens M;Dallas R;Horvath KJ;Dunlap A;Goolsby R;Johnson MM;Heckman B;Crawford J;Secord E;Purswani M;Reirden D;Rathore M;Robinson LG;Gaur AH;TERA Study Team
• 通讯作者: TERA Study Team

Correlates of High HIV Viral Load and Antiretroviral Therapy Adherence Among Viremic Youth in the United States Enrolled in an Adherence Improvement Intervention.

参与依从性改善干预措施的美国病毒血症青年中高 HIV 病毒载量与抗逆转录病毒治疗依从性的相关性。

• DOI: 10.1089/apc.2021.0005
• 发表时间: 2021
• 期刊: AIDS patient care and STDs
• 影响因子: 4.9
• 作者: Amico,KRivet;Crawford,Jessica;Ubong,Ini;Lindsey,JaneC;Gaur,AdityaH;Horvath,Keith;Goolsby,Rachel;MuellerJohnson,Megan;Dallas,Ronald;Heckman,Barbara;Filipowicz,Teresa;Polier,Melissa;Rupp,BettyM;Hudgens,Michael
• 通讯作者: Hudgens,Michael

Barriers and Facilitators to the Collection and Aggregation of Electronic Health Record HIV Data: An Analysis of Study Recruitment Venues Within the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN).

• DOI: 10.1177/0163278721998413
• 发表时间: 2021-06
• 期刊: Evaluation & the health professions
• 影响因子: 2.9
• 作者: Butame SA;De Leon JM;Lee SJ;Naar S;Genn L;Dark T;Kapogiannis BG
• 通讯作者: Kapogiannis BG

Rates of Sexually Transmitted Infection Diagnoses Among US Youth With Perinatally and Nonperinatally Acquired HIV.

• DOI: 10.1097/olq.0000000000001578
• 发表时间: 2022-03-01
• 期刊: Sexually transmitted diseases
• 影响因子: 3.1
• 作者: Neilan AM;DeMonte JB;Foote JHA;Karalius B;Patel K;Kapogiannis BG;Rudy BJ;Huszti H;Fernandez MI;Hudgens MG;Ciaranello AL
• 通讯作者: Ciaranello AL

Trajectories of Depressive Symptoms, Neurocognitive Function, and Viral Suppression With Antiretroviral Therapy Among Youth With HIV Over 36 months.

• DOI: 10.1097/qai.0000000000002653
• 发表时间: 2021-06-01
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Kohn JN;Loop MS;Kim-Chang JJ;Garvie PA;Sleasman JW;Fischer B;Rendina HJ;Woods SP;Nichols SL;Hong S
• 通讯作者: Hong S