Infection-Associated Cancer Research Training Program in Mali

项目摘要 西北大学（NU）和马里的科学，技术和技术大学， 巴马科（USTB）的预防相关癌症（NM-IAC）研究培训计划解决了一个国家 癌症研究所（NCI）的高度优先研究和一个重要的和不断增长的发病率和死亡率的来源， 撒哈拉以南非洲，特别是马里。2018年，四种最常见的感染相关癌症（IAC; 子宫颈癌、肝癌、胃癌和肺癌）占2000年所有登记癌症的四分之一以上（27%）。 马里. NM-IAC计划旨在建立一个跨学科，协作，研究培训计划， 研究人员在人口为基础的癌症流行病学和分子研究的行为，并推进 发现独特的人群特异性风险因素和生物标志物，以进行风险分层， 筛查工具的个人与潜在的感染在相关的癌症的风险增加，与 改善检测、治疗和结果的最终目标。NM-IAC计划将利用我们团队的 在非洲开展NIH资助的全球卫生研究培训项目方面拥有丰富的经验， 完善，以及我们长达十年的研究培训的非常成功的培训资源和成果 USTB和NU之间的合作。我们的中心假设是，关键学科的能力建设 参与IAC将使马里和美国的调查人员能够开发和实施新颖的， 适当的、文化上适应的风险分层和筛查工具。为了实现我们的目标，我们的具体 目标是（1）培养两（2）名博士水平的癌症流行病学家，每人专注于四个IAC之一 并有能力（i）设计和进行基于人群的癌症流行病学研究;（ii）开发 生物样本收集、处理和储存的规程;以及（iii）评估群体特异性 用于筛选和识别"高危"人群的生物标志物;和两个硕士水平的分子生物学 病理学家、一名生物统计学家和一名生物信息学家，能够（i）收集和管理临床， 实验室和人群水平的标本和数据;（ii）使用虚拟模式进行培训，教育， 远程显微诊断和培训的指导和远程病理学;以及（iii）执行 从群体水平研究中产生的全面生物统计学和生物信息学分析;（2） 提高现有教师的知识和技能，特别是早期职业教师，以促进和 通过以下方式参与IAC的机制和基于人群的研究的跨学科研究团队 中期强化讲习班和由目标1培训的科学家领导的指导研究项目; (3)优化公共卫生科学家、临床医生和卫生系统利益相关者的参与， 举办讲习班和研讨会，传播有关新型流行病学和生物标志物工具的知识， 在马里，我们制定了一系列战略，用于重点预防和检测IACs的新项目。

PROJECT SUMMARY The Northwestern University (NU) and Mali’s University of Sciences, Techniques, and Technologies of Bamako (USTTB)’s Infection-Associated Cancer (NM-IAC) Research Training Program addresses a National Cancer Institute (NCI) high research priority and a significant and growing source of morbidity and mortality in sub-Saharan Africa, particularly in Mali. In 2018, the four most common infection-associated cancers (IACs; cervical, liver, gastric and lung cancers) represented more than a quarter (27%) of all registered cancers in Mali. The NM-IAC Program seeks to build an interdisciplinary, collaborative, research training program to train researchers in the conduct of population-based cancer epidemiology and molecular studies and advance the discovery of unique population-specific risk factors and biomarkers for the development of risk stratification and screening tools of individuals with underlying infections at increased risk of associated cancers, with the ultimate goal of improving detection, treatment, and outcomes. The NM-IAC Program will leverage our team’s extensive experience in conducting NIH-funded global health research training programs in Africa, program refinements, and highly successful training resources and outcomes from our decade-long, research-training collaboration between USTTB and NU. Our central hypothesis is that building capacity in the key disciplines involved in IACs will empower Malian and US investigators to develop and implement novel, contextually appropriate, and culturally adapted risk stratification and screening tools. To achieve our goals, our specific aims are to (1) Train two (2) PhD-level cancer epidemiologists, each with a focus on one of the four IACs and capable of (i) designing and conducting population-based cancer epidemiology studies; (ii) developing protocols for biospecimen collection, processing, and storage; and (iii) evaluating population-specific biomarkers for use in screening and identifying “at-risk” populations; and Two master’s-level molecular pathologists, one biostatistician, and one bio-informatician, capable of (i) collecting and managing clinical, laboratory, and population-level specimens and data; (ii) using virtual modalities for training, education, and mentoring and telepathology for distance microscopic diagnostics and training; and (iii) performing comprehensive biostatistical and bioinformatics analyses, generated from population-level studies; (2) Enhance the knowledge and skills of existing faculty, particularly early career faculty, to contribute to and participate in interdisciplinary research teams of mechanistic and population-based studies of IACs through medium-term intensive workshops and mentored research projects led by the scientists trained in Aim 1; and (3) Optimize engagement of public health scientists, clinicians, and health system stakeholders through workshops and seminars to disseminate knowledge about the novel epidemiological and biomarker tools and strategies, for use in new programs focused on the prevention and detection of IACs in Mali.