Infection-Associated Cancer Research Training Program in Mali

项目总结 西北大学(NU)和马里科学、技术和技术大学 巴马科S感染相关癌症研究培训项目向全国发表演讲 癌症研究所(NCI)高度重视研究，是#年发病率和死亡率的一个重要且不断增长的来源 撒哈拉以南非洲，特别是在马里。2018年，四种最常见的感染相关癌症(IAC； 宫颈癌、肝癌、胃癌和肺癌)占#年登记的所有癌症的四分之一以上(27%)。 马里。NM-IAC计划寻求建立一个跨学科、协作、研究的培训计划来培训 研究人员开展以人群为基础的癌症流行病学和分子研究，并推动 发现独特的人群特有的危险因素和生物标志物，以发展风险分层和 潜在感染相关癌症风险增加的个人的筛查工具， 最终目标是改善检测、治疗和结果。NM-IAC计划将利用我们团队的 在非洲开展由美国国立卫生研究院资助的全球健康研究培训项目的丰富经验 精益求精，非常成功的培训资源和我们长达十年的研究培训成果 USTTB和NU之间的合作。我们的中心假设是，关键学科的能力建设 参与IAC将使马里和美国的调查人员能够根据背景开发和实施新的 适当的、文化适应的风险分层和筛查工具。为了实现我们的目标，我们的具体目标 目标是(1)培训两(2)名博士级别的癌症流行病学家，每人侧重于四个IAC中的一个 并有能力(I)设计和进行以人群为基础的癌症流行病学研究；(Ii)制定 生物量采集、加工和储存的议定书；以及(3)评估特定种群 用于筛选和识别“高危”人群的生物标志物；以及两个大师级分子 病理学家，一名生物统计学家和一名生物信息学家，能够(I)收集和管理临床， 实验室，以及人口一级的标本和数据；(2)利用虚拟模式进行培训、教育和 远程显微镜诊断和培训的指导和远程病理学；以及(Iii)执行 综合生物统计和生物信息学分析，由人口层面的研究产生；(2) 提高现有教员的知识和技能，特别是早期职业教员，以帮助和 参与IAC的机械性和基于人口的研究的跨学科研究团队，通过 由在目标1培训的科学家领导的中期强化讲习班和指导研究项目；以及 (3)通过以下方式优化公共卫生科学家、临床医生和卫生系统利益攸关方的参与度 举办讲习班和研讨会，传播关于新的流行病学和生物标记物工具和 战略，用于马里重点预防和检测IAC的新方案。

PROJECT SUMMARY The Northwestern University (NU) and Mali’s University of Sciences, Techniques, and Technologies of Bamako (USTTB)’s Infection-Associated Cancer (NM-IAC) Research Training Program addresses a National Cancer Institute (NCI) high research priority and a significant and growing source of morbidity and mortality in sub-Saharan Africa, particularly in Mali. In 2018, the four most common infection-associated cancers (IACs; cervical, liver, gastric and lung cancers) represented more than a quarter (27%) of all registered cancers in Mali. The NM-IAC Program seeks to build an interdisciplinary, collaborative, research training program to train researchers in the conduct of population-based cancer epidemiology and molecular studies and advance the discovery of unique population-specific risk factors and biomarkers for the development of risk stratification and screening tools of individuals with underlying infections at increased risk of associated cancers, with the ultimate goal of improving detection, treatment, and outcomes. The NM-IAC Program will leverage our team’s extensive experience in conducting NIH-funded global health research training programs in Africa, program refinements, and highly successful training resources and outcomes from our decade-long, research-training collaboration between USTTB and NU. Our central hypothesis is that building capacity in the key disciplines involved in IACs will empower Malian and US investigators to develop and implement novel, contextually appropriate, and culturally adapted risk stratification and screening tools. To achieve our goals, our specific aims are to (1) Train two (2) PhD-level cancer epidemiologists, each with a focus on one of the four IACs and capable of (i) designing and conducting population-based cancer epidemiology studies; (ii) developing protocols for biospecimen collection, processing, and storage; and (iii) evaluating population-specific biomarkers for use in screening and identifying “at-risk” populations; and Two master’s-level molecular pathologists, one biostatistician, and one bio-informatician, capable of (i) collecting and managing clinical, laboratory, and population-level specimens and data; (ii) using virtual modalities for training, education, and mentoring and telepathology for distance microscopic diagnostics and training; and (iii) performing comprehensive biostatistical and bioinformatics analyses, generated from population-level studies; (2) Enhance the knowledge and skills of existing faculty, particularly early career faculty, to contribute to and participate in interdisciplinary research teams of mechanistic and population-based studies of IACs through medium-term intensive workshops and mentored research projects led by the scientists trained in Aim 1; and (3) Optimize engagement of public health scientists, clinicians, and health system stakeholders through workshops and seminars to disseminate knowledge about the novel epidemiological and biomarker tools and strategies, for use in new programs focused on the prevention and detection of IACs in Mali.