Epigenetic study of oral HPV infection-associated oral cancer in people living with HIV in Nigeria
尼日利亚 HIV 感染者口腔 HPV 感染相关口腔癌的表观遗传学研究
基本信息
- 批准号:10705727
- 负责人:
- 金额:$ 82.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-16 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AfricaAfrica South of the SaharaAgeAreaBenignBiological AssayBiologyBiopsyBiopsy SpecimenCD4 Positive T LymphocytesCD8B1 geneCancer PatientCell CountChronicClinicalCodeCollaborationsCountryCytologyDNADNA MethylationDNA methylation profilingDataDevelopmentDiagnosisDiseaseEpidemiologyEpigenetic ProcessEuropeExogenous FactorsFundingFutureGene ExpressionGenotypeGoalsHIVHIV InfectionsHPV-High RiskHealth care facilityHigh PrevalenceHospitalsHuman PapillomavirusImmune System DiseasesImmune systemImmunologic Deficiency SyndromesIndividualInflammationInheritedInterventionLesionLiteratureLongitudinal StudiesMalignant - descriptorMalignant NeoplasmsMalignant neoplasm of cervix uteriMedicineModificationMouthwashNigeriaNigerianOncogenicOralOral SexOral cavityOutcomeParticipantPatientsPersonsPredispositionPrevalencePreventionPreventivePublic HealthRadiation OncologyResearchResourcesRiskRisk FactorsRoleSamplingSatellite HospitalsScreening for Oral CancerScreening for cancerSex BehaviorSiteSwabTestingTissuesUnited StatesUniversitiesViralViral Load resultVirusVirus Diseasesantiretroviral therapybiomarker developmentcancer biomarkersco-infectioncohortcollegecost effectiveearly detection biomarkersepigenetic markerexperiencefollow-upgenome-widehazardimprovedmalignant mouth neoplasmmalignant oropharynx neoplasmmethylation biomarkernovel strategiesoncology serviceoral HPVpredictive markerpremalignantprognosticprogression riskprospectiverecruitscreeningsexspecific biomarkerstherapeutic targettransmission processtrendtumorvirus related canceryoung adult
项目摘要
PROJECT SUMMARY/ABSTRACT
The long-term goals of this project are to a) understand the epidemiology of Human papillomavirus virus (HPV)-
associated oral and oropharyngeal cancers (OOPC) among people living with HIV (PLWH) as well as the role of
epigenetic biomarkers in OOPC, and b) to develop potential targeted interventions to improve prevention and
early detection of OOPC. HPV causes ~5% of cancers worldwide, including an increasing proportion of OOPCs;
our recent data showed that 17% of OOPC samples have HPV infections. This worsening public health problem
is even more serious in countries with high HIV prevalence, such as Nigeria. The impact of HIV infection on
immune dysfunction promotes transmission and reactivation of oncogenic HPV co-infections. HIV-HPV co-
infection then synergistically increases the prevalence of oral potentially malignant disorders (OPMDs), and the
hazards of progression to OOPC among PLWH. As HIV is controlled with antiretroviral therapy (ART), PLWH
live longer with chronic inflammation and continued immunodeficiency, making them even more susceptible to
HPV infection and its cancer-promoting consequences. Epigenetic biomarkers represent a field with untapped
potential for identifying HPV-infected PLWH who are at risk of progression to invasive OOPC. DNA methylation
(DNAm) modifications are a well-studied epigenetic mechanism in cancer including OOPC. DNAm modifications
are inducible by exogenous factors, including HIV and HPV infection and their associated cancers. Countries
like Nigeria provide unique resources and opportunities to study HPV-associated cancers in PLWH, particularly
longitudinal studies of the progression of OPMDs into malignant OOPCs. We hypothesize that oral HPV infection
may induce DNAm changes in PLWH, some of which are mechanisms in OOPC development. Such changes
may differ by HPV subtype, and can be seen in OPMDs that predict the progression to invasive OOPC. We plan
to examine tissue-specific epigenetic biomarkers in 4 groups of HIV(+) patients: 1) HPV(+) OOPC (n=150); 2)
HPV(-) OOPC (n=150); 3) HPV(+) with benign warts (n=100), and 4) HPV(+) with OPMDs (n=400). Recruitment
will be conducted at the College of Medicine, University of Ibadan/University College Hospital (COMUI/UCH) in
Nigeria, West Africa as well as 10 other hospital satellite recruitment sites. COMUI/UCH is the largest radiation
oncology referral site in Nigeria and one of the leading centers for oncological services in the region. We will also
study HIV (-) OOPC patients derived from our existing cohort (SHINI) in the same area. Our primary Aims are
to: 1) Understand the epidemiology of HPV-associated OOPCs in PLWH; 2) Identify DNAm biomarkers of HPV-
associated OOPCs in PLWH; and 3) Examine DNAm biomarkers for OOPC aggressiveness and OPMD
progression during follow up. Our research team has a long and successful collaboration record and the
Northwestern University MPIs have extensive experience studying HPV-associated cervical cancer in PLWH
through an NCI-funded U54 consortium in Nigeria.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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{{ truncateString('Lifang Hou', 18)}}的其他基金
Epigenetic study of oral HPV infection-associated oral cancer in people living with HIV in Nigeria
尼日利亚 HIV 感染者口腔 HPV 感染相关口腔癌的表观遗传学研究
- 批准号:
10530153 - 财政年份:2022
- 资助金额:
$ 82.55万 - 项目类别:
Epigenomic landscape of individual- and neighborhood-level social disadvantages and cardiovascular health disparity
个人和社区层面的社会劣势和心血管健康差异的表观基因组景观
- 批准号:
10701077 - 财政年份:2022
- 资助金额:
$ 82.55万 - 项目类别:
Epigenomic landscape of individual- and neighborhood-level social disadvantages and cardiovascular health disparity
个人和社区层面的社会劣势和心血管健康差异的表观基因组景观
- 批准号:
10531486 - 财政年份:2022
- 资助金额:
$ 82.55万 - 项目类别:
Epigenetic biomarkers of Cervical HPV in women with oral and oropharyngeal HPV, precancer and cancer
患有口腔和口咽 HPV、癌前病变和癌症的女性中宫颈 HPV 的表观遗传生物标志物
- 批准号:
10841283 - 财政年份:2022
- 资助金额:
$ 82.55万 - 项目类别:
Infection-Associated Cancer Research Training Program in Mali
马里感染相关癌症研究培训计划
- 批准号:
10440364 - 财政年份:2021
- 资助金额:
$ 82.55万 - 项目类别:
Infection-Associated Cancer Research Training Program in Mali
马里感染相关癌症研究培训计划
- 批准号:
10645169 - 财政年份:2021
- 资助金额:
$ 82.55万 - 项目类别:
Infection-Associated Cancer Research Training Program in Mali
马里感染相关癌症研究培训计划
- 批准号:
10223788 - 财政年份:2021
- 资助金额:
$ 82.55万 - 项目类别:
High Dimensional Mediation Analysis for DNA Methylation Markers Mediating Cardiovascular Health Metrics and Cardiovascular Diseases
DNA 甲基化标记介导心血管健康指标和心血管疾病的高维中介分析
- 批准号:
9918838 - 财政年份:2019
- 资助金额:
$ 82.55万 - 项目类别:
Epigenomic Biomarkers of HIV-Associated Cancers in Nigeria
尼日利亚艾滋病毒相关癌症的表观基因组生物标志物
- 批准号:
10242887 - 财政年份:2017
- 资助金额:
$ 82.55万 - 项目类别:
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