Epigenomic Biomarkers of HIV-Associated Cancers in Nigeria

尼日利亚艾滋病毒相关癌症的表观基因组生物标志物

• 批准号: 10242887
• 负责人: Lifang Hou
• 金额: $ 78.7万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10242887
• 关键词: AIDS related cancer; Address; Adverse effects; Affect; Africa; American; Area; Biological; Biological Markers; Blood; Cancer Patient; Canes; Cervical; Chronic; Clinic; Clinical; Core Facility; Country; DNA Methylation; Detection; Development; Diagnosis; Early Diagnosis; Educational Curriculum; Epigenetic Process; Exposure to; Funding; Genomics; HIV; HIV Infections; Hepatitis B; Hepatitis B Virus; Hepatitis C; Hepatitis C virus; Human Development; Human Papillomavirus; Immune system; Immunologic Deficiency Syndromes; Income; Individual; Infection; Inflammation; Infrastructure; Institution; K-Series Research Career Programs; Lead; Link; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Medical; Medical Informatics; Mentors; Methods; Molecular; Molecular Epidemiology; Mutation; Nigeria; Nigerian; Oncogenic; Oncogenic Viruses; Outcome; Pathologic; Pathology; Patients; Physicians; Pilot Projects; Play; Precancerous Conditions; Predisposition; Prevention approach; Prevention strategy; Primary carcinoma of the liver cells; Research; Research Personnel; Research Project Grants; Research Support; Risk; Risk Factors; Role; Scientist; Structure; System; Time; Tissues; Training; Training Programs; U-Series Cooperative Agreements; Universities; Ursidae Family; Viral; anticancer research; antiretroviral therapy; biomedical informatics; cancer prevention; cancer therapy; co-infection; cost; epidemiology study; epigenetic marker; epigenomics; experience; genome-wide; high risk; immune activation; improved; indexing; innovation; low and middle-income countries; medical schools; novel; predictive marker; premalignant; statistics; transmission process; tumor

Project Summary Epigenomic Biomarkers of HIV-Associated Cancers in Nigeria is a proposal from U.S. and Nigerian scientists to establish a consortium for research on two high priority HIV-associated cancers in Nigeria: hepatocellular carcinoma (HCC) and cervical cancer. The consortium will also support the enhancement of research capacity in Nigeria, a low strata middle-income sub-Saharan country with the second highest burden of HIV infection in the world. The theme of this proposal is to conduct molecular epidemiologic research to understand the epigenetic determinants of these deadly cancers. The premise for our proposal is that cancer epigenetics and infections are inextricably linked, yet significantly understudied in countries like Nigeria which have a high burden of HIV, HCC and cervical cancer. HIV and its adverse effects on the immune system promote transmission and reactivation of oncogenic viral co-infections such as hepatitis B and C, and human papilloma virus (HPV), greatly increasing the oncogenic potential in HIV-infected individuals. HIV-infected patients may also experience immune activation from HIV replication and increased exposure to traditional risk factors. All of these factors affect epigenetic biomarkers such as DNA methylation, which is considered a hallmark of cancer, and aberrations of DNA methylation in both blood and tissue have linked to increased risk of various cancers. The consortium will be led by investigators from Northwestern University and Mayo Medical School in the U.S., with partners University of Lagos and University of Jos in Nigeria. The consortium proposes to perform two Research Projects which will identify DNA methylation signatures specific to HIV-associated HCC (Project 1) and cervical cancer (Project 2). Study of epigenomic biomarkers will improve our understanding of the role of HIV co-infection and offers the main advantage of earlier diagnosis of premalignant and early stage cancers which may in turn lead to effective strategies for prevention, diagnosis and treatment. The aims of our consortium are: 1) identify epigenetic determinants of HIV-associated HCC and cervical caner in Nigeria; 2) examine whether epigenetic biomarkers are associated with clinical features of HIV-associated HCC and cervical cancer and whether such biomarkers predict development of for these two cancers; 3) provide training and mentoring opportunities for Nigerian investigators in conducting molecular epidemiology studies with a focus on epigenetic biomarkers; and 4) establish two shared core facilities for i) biomedical informatics and statistics, and ii) pathology and genomics. This cooperative agreement will provide an exceptional opportunity to leverage our existing expertise and expand that effort at two of the leading medical universities in Nigeria, the most populous country in Africa with an exceptionally high burden HIV and oncogenic viruses such as HPV and hepatitis B and C. Our results will provide useful and novel information for HIV-associated cancer prevention and treatment most relevant to low- and middle-income countries.

项目总结

项目成果

Vaginal microbiome community state types and high-risk human papillomaviruses in cervical precancer and cancer in North-central Nigeria.

• DOI: 10.1186/s12885-023-11187-5
• 发表时间: 2023-07-20
• 期刊: BMC CANCER
• 影响因子: 3.8
• 作者: Musa, Jonah;Maiga, Mamoudou;Green, Stefan J.;Magaji, Francis A.;Maryam, Ali J.;Okolo, Mark;Nyam, Chuwang J.;Cosmas, Nanma T.;Silas, Olugbenga A.;Imade, Godwin E.;Zheng, Yinan;Joyce, Brian T.;Diakite, Brehima;Morhason-Bello, Imran;Achenbach, Chad J.;Sagay, Atiene S.;Ujah, Innocent A. O.;Murphy, Robert L.;Hou, Lifang;Mehta, Supriya Dinesh
• 通讯作者: Mehta, Supriya Dinesh

Hepatocellular carcinoma presentation and prognosis among Nigerian adults with and without HIV.

• DOI: 10.1371/journal.pone.0282539
• 发表时间: 2023
• 期刊: PloS one
• 影响因子: 3.7