Infection-Associated Cancer Research Training Program in Mali

马里感染相关癌症研究培训计划

• 批准号: 10223788
• 负责人: Lifang Hou
• 金额: $ 26.37万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10223788
• 关键词: Address; Africa; Africa South of the Sahara; Bioinformatics; Biological Markers; Biometry; Clinical Management; Collaborations; Collection; Data; Detection; Diagnostic; Discipline; Doctor of Philosophy; Educational workshop; Epidemiologist; Epidemiology; Faculty; Funding; Goals; Health system; Individual; Infection; Interdisciplinary Study; Knowledge; Laboratories; Mali; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of liver; Malignant neoplasm of lung; Mentors; Microscopic; Modality; Molecular; Morbidity - disease rate; National Cancer Institute; Outcome; Pathologist; Population; Population Study; Populations at Risk; Prevention; Protocols documentation; Public Health; Research Personnel; Research Priority; Research Project Grants; Research Training; Resources; Risk; Risk Factors; Science; Scientist; Screening procedure; Source; Specimen; Techniques; Technology; Telepathology; Training; Training Programs; Training and Education; Treatment outcome; United States National Institutes of Health; Universities; anticancer research; biomarker development; cancer epidemiology; design; early-career faculty; epidemiology study; experience; global health; improved; malignant stomach neoplasm; mortality; novel; population based; programs; risk stratification; screening; skills; specific biomarkers; tool; virtual

PROJECT SUMMARY The Northwestern University (NU) and Mali’s University of Sciences, Techniques, and Technologies of Bamako (USTTB)’s Infection-Associated Cancer (NM-IAC) Research Training Program addresses a National Cancer Institute (NCI) high research priority and a significant and growing source of morbidity and mortality in sub-Saharan Africa, particularly in Mali. In 2018, the four most common infection-associated cancers (IACs; cervical, liver, gastric and lung cancers) represented more than a quarter (27%) of all registered cancers in Mali. The NM-IAC Program seeks to build an interdisciplinary, collaborative, research training program to train researchers in the conduct of population-based cancer epidemiology and molecular studies and advance the discovery of unique population-specific risk factors and biomarkers for the development of risk stratification and screening tools of individuals with underlying infections at increased risk of associated cancers, with the ultimate goal of improving detection, treatment, and outcomes. The NM-IAC Program will leverage our team’s extensive experience in conducting NIH-funded global health research training programs in Africa, program refinements, and highly successful training resources and outcomes from our decade-long, research-training collaboration between USTTB and NU. Our central hypothesis is that building capacity in the key disciplines involved in IACs will empower Malian and US investigators to develop and implement novel, contextually appropriate, and culturally adapted risk stratification and screening tools. To achieve our goals, our specific aims are to (1) Train two (2) PhD-level cancer epidemiologists, each with a focus on one of the four IACs and capable of (i) designing and conducting population-based cancer epidemiology studies; (ii) developing protocols for biospecimen collection, processing, and storage; and (iii) evaluating population-specific biomarkers for use in screening and identifying “at-risk” populations; and Two master’s-level molecular pathologists, one biostatistician, and one bio-informatician, capable of (i) collecting and managing clinical, laboratory, and population-level specimens and data; (ii) using virtual modalities for training, education, and mentoring and telepathology for distance microscopic diagnostics and training; and (iii) performing comprehensive biostatistical and bioinformatics analyses, generated from population-level studies; (2) Enhance the knowledge and skills of existing faculty, particularly early career faculty, to contribute to and participate in interdisciplinary research teams of mechanistic and population-based studies of IACs through medium-term intensive workshops and mentored research projects led by the scientists trained in Aim 1; and (3) Optimize engagement of public health scientists, clinicians, and health system stakeholders through workshops and seminars to disseminate knowledge about the novel epidemiological and biomarker tools and strategies, for use in new programs focused on the prevention and detection of IACs in Mali.

项目摘要 西北大学（NU）和马里科学大学，技术和技术 Bamako（USTTB）的感染相关癌症（NM-IAC）研究培训计划解决了一个国家 癌症研究所（NCI）的高度研究优先级，以及在 撒哈拉以南非洲，特别是在马里。在2018年，最常见的感染相关的四种癌症（IACS； 宫颈，肝，胃癌和肺癌）代表所有注册癌症的四分之一以上（27％） 马里。 NM-IAC计划旨在建立跨学科的协作，研究培训计划，以培训 研究人员从事基于人群的癌症流行病学和分子研究，并推进 发现独特的特定人群风险因素和生物标志物，以发展风险分层和 筛查具有潜在感染的个体的工具，以增加相关癌症的风险增加 改善检测，治疗和结果的最终目标。 NM-IAC计划将利用我们团队的 在非洲进行NIH资助的全球健康研究培训计划方面的丰富经验，计划 精炼以及非常成功的培训资源和我们十年的研究培训的结果 USTTB和NU之间的合作。我们的中心假设是关键学科中的建筑能力 参与IACS将使马里安和美国调查人员能够开发和实施小说 适当且具有文化适应的风险分层和筛查工具。为了实现我们的目标，我们的具体 目的是（1）训练两（2）个PHD级癌症流行病学家，每个人都重点是四个IAC之一 并能够（i）设计和进行基于人群的癌症流行病学研究； （ii）发展 生物测量收集，处理和存储的协议； （iii）评估人口特定的 用于筛查和识别“处于危险”人群的生物标志物；和两个师父的分子 病理学家，一位生物统计学家和一位生物形式的人，能够（i）收集和管理临床， 实验室以及人口级标本和数据； （ii）使用虚拟方式进行培训，教育和 远程显微镜诊断和培训的指导和心脏病学； （iii）表演 由人口水平研究产生的全面生物统计和生物信息学分析； （2） 增强现有教师，尤其是早期职业教师的知识和技能，以贡献和 通过参加IAC的机械和人群研究的跨学科研究团队 在AIM 1中受过培训的科学家领导的中期密集研讨会和修改研究项目；和 （3）通过优化公共卫生科学家，临床医生和卫生系统利益相关者的参与 讲习班和下水道，以传播有关新型流行病学和生物标志物工具的知识 策略，用于用于预防和发现马里IAC的新计划。