Administrative Core

项目摘要 我们建议建立一个联盟，研究“尼日利亚艾滋病毒相关癌症的表观基因组生物标志物”。 我们的研究重点和核心服务发展计划已被我们的尼日利亚合作伙伴优先考虑， 乔斯大学（UniJos），高原州，尼日利亚位于该国的中心和拉各斯大学 （UniLag），位于人口稠密的西南部的拉各斯州。我们专注于HIV相关的表观遗传学 肝细胞癌（HCC）和宫颈癌是合理的，我们广泛的合作研究历史 病毒性疾病包括HIV、人乳头瘤病毒、B型肝炎和C型肝炎病毒。西北大学和 马约医学院将作为高收入的美国合作机构，这是有道理的长期 与尼日利亚机构的研究和研究培训合作的历史，加上其在以下方面的专门知识： 全球健康和充足的补充资源。行政核心的具体目标是：1. 建立行政结构、沟通机制、决策和冲突解决机制 U 54联盟的流程，2。确定建立和召集外部咨询委员会的程序 该小组将包括决策者、健康教育专家、机构和政府领导人， 来自尼日利亚的主要意见领袖和社区倡导者;协调行政工作， 生物医学信息学和统计学核心（BISC）、职业提升核心（CEC）、病理学和 基因组学核心（PGC）和项目1（HCC）和2（宫颈）。AC将负责整体 联合体的行政、协调和管理，以及促进和协调 所有核心和项目的会议和活动。AC将负责评估所有联合体 活动，包括监测项目进度，监测拟议的时间表，监督质量控制 程序，跟踪和报告实现既定研究目标的进展情况。我们将开发短，中， 以及评估联合体质量、数量和连续性的长期指标。东亚运动会将于 其成员将包括：决策者、健康教育专家、机构和政府 领导人、关键意见领袖和社区倡导者。咨询委员会的总体目标是支持和 促进项目1（HCC）和项目2（宫颈癌）中提议的研究，为培训提供行政后勤服务 管理CEC下的活动，并管理BISC和PGC提供的研究服务。

Project Summary We propose to establish a Consortium to study “Epigenomic Biomarkers of HIV-Associated Cancers in Nigeria.” Our research focus and core services development plan has been prioritized by our Nigerian partners at University of Jos (UniJos), Plateau State, Nigeria located in the center of the country and University of Lagos (UniLag), Lagos State in the densely populated southwest. Our focus on the epigenetics of HIV-associated hepatocellular carcinoma (HCC) and cervical cancer is justified by our extensive collaborative research history in viral diseases including HIV, human papilloma virus, hepatitis B and C viruses. Northwestern University and Mayo Medical School will serve as the high-income American partner institutions which is justified by the long history of research and research training collaboration with the Nigerian institutions coupled with its expertise in global health and ample complementary resources. The specific aims of the Administrative Core (AC) are: 1. establish the administration structure, communication mechanisms, decision making and conflict resolution processes for the U54 Consortium, 2. define the process for establishing and convening the External Advisory Group (EAG) which will include policy makers, health education specialists, institutional and government leaders, key opinion leaders and community advocates from Nigeria, and 3. coordinate administrative efforts between the Biomedical Informatics and Statistics Core (BISC), Career Enhancement Core (CEC), Pathology and Genomics Core (PGC) and Projects 1 (HCC) and 2 (cervical). The AC will be responsible for the overall administration, coordination and management of the Consortium as well as facilitation and coordination of meetings and activities of all cores and projects. The AC will be responsible for evaluating all Consortium activities, including monitoring project progress, monitoring proposed timelines, overseeing quality control procedures, and tracking and reporting progress towards stated research goals. We will develop short, medium and long term metrics for evaluating the quality, quantity, and continuity of the Consortium. An EAG will be formed and its membership will include: policy makers, health education specialists, institutional and government leaders, key opinion leaders and community advocates. The overall goal of the AC will be to support and facilitate research proposed in Projects 1 (HCC) and 2 (cervical), provide administrative logistics for training activities under the CEC, and manage research services provided by the BISC and PGC.